Abstract: A septum for sealing a vial assembly having a vial including a neck region including a first width comprises a top surface, a bottom surface disposed opposite the top surface, a radially extending outer side surface disposed between the top surface and the bottom surface, a plurality of ribs disposed on the top surface, and a plurality of valleys. Each valley may be disposed between to space apart at least two ribs of the plurality of ribs. The plurality of ribs may include at least an interior first rib, an intermediate rib, and an exterior outer rib. The interior first rib may include an outer wall, the outer wall configured to radially compress against an interior wall of the neck region of the vial, the outer wall including a height that is greater than a height of the intermediate rib and the exterior outer rib.

Abstract: Systems and methods involve a vial assembly system comprising a vial assembly and needle. The vial assembly comprises a septum, neck region, and particulate region comprising a bypass valve, the neck region comprising a top, bottom, and sidewall. The needle comprises a port and a tip configured to puncture the septum that is configured to receive the needle such that the port is disposed in the neck region. A bypass path includes a first end and a second end, the bypass valve is connected to the first end, the second end ends at or within the sidewall, the bypass path is configured to provide a fluid flow path to the needle alternate to a first path upon a build-up of pressure for fluid flow in the vial assembly, and the first path is directly disposed in the vial assembly between the particulate region and the neck region.

Abstract: A medical device for treating coronary artery disease, peripheral arterial disease or varicose veins includes an elongated support and a heat expandable element of muscle polymer carried on that elongated support. The medical device may also include a heating element. When activated, the heating element produces heat that causes the muscle polymer to expand into a position in closer proximity to the tissue to be treated.

Abstract: A medical device for treating coronary artery disease, peripheral arterial disease or varicose veins includes an elongated support and a heat expandable element of muscle polymer carried on that elongated support. The medical device may also include a heating element. When activated, the heating element produces heat that causes the muscle polymer to expand into a position in closer proximity to the tissue to be treated.

Abstract: An introducer sheath may include a displacement sensor that detects displacement of a catheter within the introducer sheath. The displacement sensor may employ induction-based, optical-based or mechanical-based techniques for detecting the displacement. The displacement sensor may include a display on which the detected displacement is presented to a clinician. The displacement sensor may allow the clinician to provide user input to reset the displacement.