Abstract: An IOP control system for treatment of an ocular condition includes a drainage device sized for implantation into the eye of the patient, the drainage device including a fluid flow pathway to allow the flow of fluid from an inlet port to an outlet port. The drainage device also includes a flow system disposed within the drainage device and including a displaceable portion forming a part of the fluid flow pathway, the displaceable portion being displaceable via a magnetic field. An actuation system may be physically separate from the drainage device and may be configured to cooperate with the displaceable portion to displace the displaceable portion via the magnetic field to set free buildup or debris in the flow pathway.

Abstract: A system for implantation in an eye of a patient includes a flow device sized for implantation into the eye of the patient. The flow device includes a fluid flow passageway and a flow system. The flow system may include a regulator having a magnetic element, and may be displaceable in the fluid flow passageway to affect flow through the fluid flow passageway. The system may also include a control device physically separate from the flow device and configured to be disposed outside the eye, the control device comprising an actuator magnetic field generator configured to act on the magnetic element to adjust the regulator in the flow system to selectively adjust flow through the flow device in response to changes in intraocular pressure.

Abstract: A method of implanting a treatment device into an eye of a patient comprises inserting a drainage device including a flow system, an inlet tube, and an outlet tube into a subconjunctival space. The inlet tube includes a proximal end coupled to the flow system in the subconjunctival space. The method includes passing a distal end of the inlet tube through a pars plana into a posterior segment of the eye.

Abstract: Described herein is a method of implanting a glaucoma drainage device in an eye having a vitreous chamber and a drainage site. The glaucoma drainage device comprises a tube including a lumen extending from an inlet end to an outlet end, and includes a control element that regulates the amount of fluid flow through the glaucoma drainage device. The method comprises implanting the glaucoma drainage device into pars plana tissue from the vitreous chamber, such that the device extends between the vitreous chamber and the drainage site.

Abstract: A method of implanting a treatment device into an eye of a patient comprises inserting a drainage device including a flow system, an inlet tube, and an outlet tube into a subconjunctival space. The inlet tube includes a proximal end coupled to the flow system in the subconjunctival space. The method includes passing a distal end of the inlet tube through a pars plana into a posterior segment of the eye.

Abstract: Described herein is a method of implanting a glaucoma drainage device in an eye having a vitreous chamber and a drainage site. The glaucoma drainage device comprises a tube including a lumen extending from an inlet end to an outlet end, and includes a control element that regulates the amount of fluid flow through the glaucoma drainage device. The method comprises implanting the glaucoma drainage device into pars plana tissue from the vitreous chamber, such that the device extends between the vitreous chamber and the drainage site.

Abstract: An IOP control system for treatment of an ocular condition includes a drainage device sized for implantation into the eye of the patient, the drainage device including a fluid flow pathway to allow the flow of fluid from an inlet port to an outlet port. The drainage device also includes a flow system disposed within the drainage device and including a displaceable portion forming a part of the fluid flow pathway, the displaceable portion being displaceable via a magnetic field. An actuation system may be physically separate from the drainage device and may be configured to cooperate with the displaceable portion to displace the displaceable portion via the magnetic field to set free buildup or debris in the flow pathway.

Abstract: A system for implantation in an eye of a patient includes a flow device sized for implantation into the eye of the patient. The flow device includes a fluid flow passageway and a flow system. The flow system may include a regulator having a magnetic element, and may be displaceable in the fluid flow passageway to affect flow through the fluid flow passageway. The system may also include a control device physically separate from the flow device and configured to be disposed outside the eye, the control device comprising an actuator magnetic field generator configured to act on the magnetic element to adjust the regulator in the flow system to selectively adjust flow through the flow device in response to changes in intraocular pressure.

Abstract: An injection device includes a dispensing chamber, a plunger, a controller, a temperature control device, and a memory device. The dispensing chamber has an inner surface and an outer surface. The inner surface defines a cavity for receiving a quantity of a substance. The plunger is engaged with the inner surface of the dispensing chamber, is capable of sliding in the cavity of the dispensing chamber, and is fluidly sealed to the inner surface of the dispensing chamber. The controller controls the operation of the injection device. The temperature control device at least partially surrounds the dispensing chamber. The memory device has a parameter stored on it. The controller uses the parameter from the memory device to operate the injection device.

Abstract: The present invention is an ophthalmic injection system with a limited reuse assembly and a tip segment. The tip segment is connectable to and removable from the limited reuse assembly. The tip segment includes a dispensing chamber, a plunger, and a housing. The dispensing chamber holds a quantity of a substance to be injected into an eye. The proximate end of the plunger has a first mechanical linkage interface. The limited reuse assembly of the ophthalmic injection system has a power source, a controller, a motor, a second mechanical linkage interface located on an end of the motor shaft; and a second housing. The first mechanical linkage interface is mateable with the second mechanical linkage interface such that when the tip segment is connected to the limited reuse assembly, the first mechanical linkage interface mates with the second mechanical linkage interface so that motion of the shaft results in motion of the plunger.

Abstract: A small gauge pulsed electric field/aspirator probe. The probe has a generally cylindrical cannula with a generally smooth distal end. A port is located near a distal end of the cannula on a side of the cannula. A pair of electrodes is located at the port. An electric pulse generator is coupled to the pair of electrodes. A distance between the distal end of the cannula and the port is approximately equal to the distance between a back wall of Schlemm's canal and a trabecular meshwork in a human eye. The electric pulse generator applies a pulsed electric field to the pair of electrodes sufficient to dissociate protein bonds that hold the trabecular meshwork together.

Abstract: An ophthalmic injection system has a tip segment attachable to and removable from a limited reuse assembly. The tip segment has a dispensing chamber housing, a plunger, a needle, a temperature control device, a thermal sensor, and a first housing at least partially enclosing the dispensing chamber housing, the temperature control device and the plunger. The limited reuse assembly has an actuator with a shaft, a power source for providing power to the actuator, a controller for controlling the actuator, a mechanical linkage interface, and a second housing at least partially enclosing the power source, the controller, and the actuator. The mechanical linkage interface is coupled to the actuator shaft and has a mating surface on one end. The substance is injected after the temperature of the substance is altered.

Abstract: An injection device assembly includes a dispensing chamber housing and a plunger. The dispensing chamber housing is coupled to a needle. The dispensing chamber housing has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. A dosage of a substance is cast into the dispensing chamber housing or cast onto a plunger that is inserted into the dispensing chamber housing.

Abstract: The present invention is a method of treating glaucoma by electrically stimulating the ciliary muscle to produce shear stress on the trabecular meshwork sufficient for cytokine production. A device for electrically stimulating the ciliary muscle includes a pair of electrodes configured to provide a voltage to the ciliary muscle. The electrodes are coupled to a voltage source. A controller operates to apply the voltage to the ciliary muscle.

Abstract: An ophthalmic injection device has a dispensing chamber housing, a needle fluidly coupled to a dispensing chamber, a power source for providing current to the dispensing chamber housing, a controller for controlling the power source, and a housing at least partially enclosing the dispensing chamber housing, the power source, and the controller. The dispensing chamber housing is made of a shape memory alloy and has an inner surface defining a dispensing chamber for receiving a quantity of a substance. The controller directs a first current to the dispensing chamber housing to heat the substance contained in the dispensing chamber and a second current to the dispensing chamber housing to alter the shape of the dispensing chamber housing to deliver the substance.

Abstract: An injection device includes a dispensing chamber, a plunger, a controller, a memory device resistant to sterilization, and a housing at least partially enclosing the dispensing chamber and the plunger. The dispensing chamber has an inner surface and an outer surface. The inner surface defines a cavity for receiving a quantity of a substance. The plunger is engaged with the inner surface of the dispensing chamber, is capable of sliding in the cavity of the dispensing chamber, and is fluidly sealed to the inner surface of the dispensing chamber. The controller controls the operation of the injection device. The controller reads dosage data from the memory device and operates the injection device to deliver a dosage corresponding to the dosage data.

Abstract: The present invention is an ophthalmic injection system with a limited reuse assembly and a tip segment. The tip segment is connectable to and removable from the limited reuse assembly. The tip segment includes a dispensing chamber, a plunger, and a housing. The dispensing chamber holds a quantity of a substance to be injected into an eye. The proximate end of the plunger has a first mechanical linkage interface. The limited reuse assembly of the ophthalmic injection system has a power source, a controller, a motor, a second mechanical linkage interface located on an end of the motor shaft; and a second housing. The first mechanical linkage interface is mateable with the second mechanical linkage interface such that when the tip segment is connected to the limited reuse assembly, the first mechanical linkage interface mates with the second mechanical linkage interface so that motion of the shaft results in motion of the plunger.

Abstract: An ophthalmic injection device has a dispensing chamber housing, a plunger, an actuator for driving the plunger, a temperature control device, and a temperature release mechanism. The dispensing chamber housing has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. The plunger is engaged with the inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The temperature control device at least partially surrounds the dispensing chamber housing and is capable of altering the temperature of the substance in the dispensing chamber. The temperature release mechanism is in a locked position when the substance is outside the proper temperature range and an unlocked position when the substance is in the proper temperature range.

Abstract: The present invention is a method of operating an ophthalmic hand piece. A connection between a tip segment and a limited reuse assembly is recognized. A type of tip segment connected to the limited reuse assembly is determined. Dosage information is received. A first input is received. In response to the first input, a heater is activated to heat a substance contained in a dispensing chamber. After the substance has reached a desired temperature range, the dosage information is used to control a distance a plunger travels. A second input is received. In response to the second input a motor is activated, and the drug is delivered into the eye.

Abstract: An ophthalmic injection device has a dispensing chamber, a storage chamber, a piezoelectric array, a needle fluidly coupled to the dispensing chamber, a power source for providing power to the piezoelectric array, and a controller for controlling the power source. A dispensing chamber housing has an inner surface and an outer surface. The inner surface defines a dispensing chamber for receiving a quantity of a substance. The storage chamber is located near the dispensing chamber housing. The piezoelectric array is located between the storage chamber and the dispensing chamber housing. A housing at least partially encloses the dispensing chamber housing, the storage chamber, the piezoelectric array, the power source, and the controller. The piezoelectric array is activated to pump the substance from the storage chamber to the dispensing chamber.