Patents by Inventor Casey Maguire

Casey Maguire has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant adeno associated virus encoding clarin-1 and uses thereof
    Patent number: 12129287
    Abstract: Aspects of the disclosure relate to compositions and methods for treating hereditary hearing loss and/or vision loss, for example, due to Usher syndrome, Type 3A. In some embodiments, the disclosure provides a recombinant adeno-associated virus comprising: (i) an AAV-S capsid protein, and (ii) an isolated nucleic acid comprising a transgene (e.g., a transgene for expressing a clarin-1 protein). The present disclosure also provides methods of treating hereditary hearing loss and/or vision loss (e.g., Usher Syndrome, Type 3A) using the same.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: October 29, 2024
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David P. Corey, Casey A. Maguire, Killian S. Hanlon, Maryna V. Ivanchenko
  • GENE THERAPY FOR TUBEROUS SCLEROSIS
    Publication number: 20240343768
    Abstract: The invention provides compositions and methods for treating tuberous sclerosis complex (TSC). In particular, provided are condensed tuberins (cTuberins), cTuberin nucleic acids, and recombinant adeno-associated viruses (rAAVs) carrying a cTuberin nucleic acid for treating a patient with TSC.
    Type: Application
    Filed: March 12, 2024
    Publication date: October 17, 2024
    Inventors: Xandra BREAKEFIELD, Casey MAGUIRE, Shilpa PRABHAKAR, David YELLEN
  • AAV vectors encoding clarin-1 or GJB2 and uses thereof
    Patent number: 12054724
    Abstract: Aspects of the disclosure relate to compositions and methods useful for treating hereditary hearing loss, for example, Usher syndrome type 3A or nonsyndromic hearing loss and deafness (DFNB1). In some embodiments, the disclosure provides isolated nucleic acids, vectors, and rAAV.9.PHP.B comprising a transgene encoding a Clarin-1 or a GJB2, and methods of treating hearing loss using the same.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: August 6, 2024
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Casey A. Maguire, David P. Corey, Bence Gyorgy
  • AAV Capsids and Uses Thereof
    Publication number: 20240209394
    Abstract: Described herein are capsid peptides that mediated efficient AAV transduction of the brain vasculature, mainly endothelial cells and pericytes, as well as smooth muscle cells, compositions (including AAV), and methods of using the same. Embodiments of the invention encompass AAV capsid proteins comprising an amino acid sequence that comprises at least four, at least five, or at least six contiguous amino acids from the sequence PRPPSTH (SEQ ID NO: 1); MAEPGAR (SEQ ID NO: 2); SQDPSTL (SEQ ID NO: 3); or MLYADNT (SEQ ID NO: 4).
    Type: Application
    Filed: April 27, 2022
    Publication date: June 27, 2024
    Inventors: Patricia L. Musolino, Casey A. Maguire, Eloise Hudry, Killian S. Hanlon
  • Gene therapy for tuberous sclerosis
    Patent number: 11958887
    Abstract: The invention provides compositions and methods for treating tuberous sclerosis complex (TSC). In particular, provided are condensed tuberins (cTuberins), cTuberin nucleic acids, and recombinant adeno-associated viruses (rAAVs) carrying a cTuberin nucleic acid for treating a patient with TSC.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: April 16, 2024
    Assignee: The General Hospital Corporation
    Inventors: Xandra Breakefield, Casey Maguire, Shilpa Prabhakar, David Yellen
  • ABCD1 FOR TREATMENT OF NEURODISORDERS
    Publication number: 20230365967
    Abstract: Methods of the invention encompass delivery of nucleic acid sequences encoding ABCD1 for the treatment of X-linked Adrenoleukodystrophy (X-ALD), e.g., for Adrenomyeloneuropathy (AMN).
    Type: Application
    Filed: April 4, 2023
    Publication date: November 16, 2023
    Inventors: Casey A. Maguire, Florian Eichler, Yi Gong
  • Hybrid System for Efficient Gene Delivery to Cells of the Inner Ear
    Publication number: 20220378947
    Abstract: Methods for introducing a gene into a cell of the inner ear, e.g., a cochlear or vestibular cell, e.g., a hair cell, e.g., for therapy, that include the use of exosomes associated with one or more adeno-associated viral (AAV) particles.
    Type: Application
    Filed: June 23, 2022
    Publication date: December 1, 2022
    Inventors: Casey A. Maguire, David P. Corey, Bence Gyorgy
  • ENGINEERED ADENO-ASSOCIATED (AAV) VECTORS FOR TRANSGENE EXPRESSION
    Publication number: 20220195458
    Abstract: Engineered AAV vectors for transgene expression, e.g., in the CNS, PNS, inner ear, heart, or retina, and methods of use thereof. Also provided are methods for discovering new engineered AAV vectors that mediate transgene expression in desired cell types.
    Type: Application
    Filed: March 30, 2020
    Publication date: June 23, 2022
    Inventors: Casey A. Maguire, Eloise Marie Hudry, Killian S. Hanlon
  • RECOMBINANT ADENO ASSOCIATED VIRUS ENCODING CLARIN-1 AND USES THEREOF
    Publication number: 20220119475
    Abstract: Aspects of the disclosure relate to compositions and methods for treating hereditary hearing loss and/or vision loss, for example, due to Usher syndrome, Type 3A. In some embodiments, the disclosure provides a recombinant adeno-associated virus comprising: (i) an AAV-S capsid protein, and (ii) an isolated nucleic acid comprising a transgene (e.g., a transgene for expressing a clarin-1 protein). The present disclosure also provides methods of treating hereditary hearing loss and/or vision loss (e.g., Usher Syndrome, Type 3A) using the same.
    Type: Application
    Filed: September 14, 2021
    Publication date: April 21, 2022
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David P. Corey, Casey A. Maguire, Killian S. Hanlon, Maryna V. Ivanchenko
  • AAV VECTORS ENCODING CLARIN-1 OR GJB2 AND USES THEREOF
    Publication number: 20210079406
    Abstract: Aspects of the disclosure relate to compositions and methods useful for treating hereditary hearing loss, for example, Usher syndrome type 3A or nonsyndromic hearing loss and deafness (DFNB1). In some embodiments, the disclosure provides isolated nucleic acids, vectors, and rAAV.9.PHP.B comprising a transgene encoding a Clarin-1 or a GJB2, and methods of treating hearing loss using the same.
    Type: Application
    Filed: April 10, 2019
    Publication date: March 18, 2021
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Casey A. Maguire, David P. Corey, Bence Gyorgy
  • Use of Microvesicles in the Treatment of Medical Conditions
    Publication number: 20210040499
    Abstract: Disclosed herein are populations of microvesicles containing or otherwise associated with viral particles, methods of producing these purified populations, and methods of using these purified populations in a variety of diagnostic, therapeutic and/or prophylactic indications.
    Type: Application
    Filed: June 23, 2020
    Publication date: February 11, 2021
    Applicant: THE GENERAL HOSPITAL CORPORATION d/b/a Massachusetts General Hospital
    Inventors: Johan Karl Olov Skog, Casey Maguire
  • Use of microvesicles in the treatment of medical conditions
    Patent number: 10731179
    Abstract: This invention relates generally to populations of microvesicles containing or otherwise associated with viral particles, methods of producing these purified populations, and methods of using these purified populations in a variety of diagnostic, therapeutic and/or prophylactic indications.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: August 4, 2020
    Assignee: The General Hospital Corporation
    Inventors: Johan Karl Olov Skog, Casey Maguire
  • GENE THERAPY FOR TUBEROUS SCLEROSIS
    Publication number: 20200079824
    Abstract: The invention provides compositions and methods for treating tuberous sclerosis complex (TSC). In particular, provided are condensed tuberins (cTuberins), cTuberin nucleic acids, and recombinant adeno-associated viruses (rAAVs) carrying a cTuberin nucleic acid for treating a patient with TSC.
    Type: Application
    Filed: May 17, 2018
    Publication date: March 12, 2020
    Inventors: Xandra BREAKEFIELD, Casey MAGUIRE, Shilpa PRABHAKAR, David YELLEN
  • Intrathecal delivery of nucleic acid sequences encoding ABCD1 for treatment of adrenomyeloneuropathy
    Patent number: 10519445
    Abstract: Methods of the invention encompass delivery of nucleic acid sequences encoding ABCD1 for the treatment of X-linked Adrenoleukodystrophy (X-ALD), e.g., for Adrenomyeloneuropathy (AMN).
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: December 31, 2019
    Assignee: The General Hospital Corporation
    Inventors: Casey A. Maguire, Florian Eichler
  • Use of microvesicles in the treatment of medical conditions
    Patent number: 10421977
    Abstract: This invention relates generally to populations of microvesicles containing or otherwise associated with viral particles, methods of producing these purified populations, and methods of using these purified populations in a variety of diagnostic, therapeutic and/or prophylactic indications.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: September 24, 2019
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Johan Karl Olov Skog, Casey Maguire
  • Use of Microvesicles in the Treatment of Medical Conditions
    Publication number: 20190264227
    Abstract: This invention relates generally to populations of microvesicles containing or otherwise associated with viral particles, methods of producing these purified populations, and methods of using these purified populations in a variety of diagnostic, therapeutic and/or prophylactic indications.
    Type: Application
    Filed: March 20, 2019
    Publication date: August 29, 2019
    Applicant: THE GENERAL HOSPITAL CORPORATION d/b/a Massachusetts General Hospital
    Inventors: Johan Karl Olov Skog, Casey Maguire
  • INTRATHECAL DELIVERY OF NUCLEIC ACID SEQUENCES ENCODING ABCD1 FOR TREATMENT OF ADRENOMYELONEUROPATHY
    Publication number: 20190225967
    Abstract: Methods of the invention encompass delivery of nucleic acid sequences encoding ABCD1 for the treatment of X-linked Adrenoleukodystrophy (X-ALD), e.g., for Adrenomyeloneuropathy (AMN).
    Type: Application
    Filed: April 2, 2019
    Publication date: July 25, 2019
    Inventors: Casey A. Maguire, Florian Eichler
  • Hybrid System for Efficient Gene Delivery to Cells of the Inner Ear
    Publication number: 20190038778
    Abstract: Methods for introducing a gene into a cell of the inner ear, e.g., a cochlear or vestibular cell, e.g., a hair cell, e.g., for therapy, that include the use of exosomes associated with one or more adeno-associated viral (AAV) particles.
    Type: Application
    Filed: February 3, 2017
    Publication date: February 7, 2019
    Inventors: Casey A. Maguire, David P. Corey, Bence Gyorgy
  • INTRATHECAL DELIVERY OF NUCLEIC ACID SEQUENCES ENCODING ABCD1 FOR TREATMENT OF ADRENOMYELONEUROPATHY
    Publication number: 20180320176
    Abstract: Methods of the invention encompass delivery of nucleic acid sequences encoding ABCD1 for the treatment of X-linked Adrenoleukodystrophy (X-ALD), e.g., for Adrenomyeloneuropathy (AMN).
    Type: Application
    Filed: November 3, 2016
    Publication date: November 8, 2018
    Inventors: Casey A. Maguire, Florian Eichler
  • Methods of isolating extracellular vesicles
    Patent number: 9829483
    Abstract: The specification provides methods for isolating extracellular vesicles. Extracellular vesicles can be efficiently isolated, e.g., from biological fluids or cell culture media, using a heparin-coated solid support.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: November 28, 2017
    Assignee: The General Hospital Corporation
    Inventors: Leonora Balaj, Casey A. Maguire, Johan Skog, Xandra O. Breakefield