Abstract: The disclosure relates to betaretroviruses (genus Betaretrovirus), and recombinant betaretroviral envelope (rENV) protein for use in viral vector platforms, an engineered delivery vehicle and gene therapy, their associated methods of use and manufacture. In particular, the present disclosure provides compositions and methods to tune betavirus envelope proteins such that they target a particular cell surface receptor; i.e., are cell and/or tissue-type specific, allowing for better site-specific transgene delivery and expression.

Abstract: System for constructing a building implementing a controller. The system includes a first control arm and a second control arm. The system also includes an extrusion head located on a distal end of the second control arm. The controller is operable to adjust the first control arm to hold a distal end stead within a predetermined window of coordinates. The controller is also operable to position the second control arm such that the extrusion head is located according to the controller directions.

Abstract: A three-dimensional printing system including at least one positioning mechanism, and at least one end effector movably connected to the at least one positioning mechanism. The at least one end effector includes at least one mixing head configured to dispense a material, and at least one subtractive tool configured to subtract at least a portion of the material such that a desired design is achieved.

Abstract: System for constructing a building implementing a controller. The system includes a first control arm and a second control arm. The system also includes an extrusion head located on a distal end of the second control arm. The controller is operable to adjust the first control arm to hold a distal end stead within a predetermined window of coordinates. The controller is also operable to position the second control arm such that the extrusion head is located according to the controller directions.

Abstract: System for constructing a building implementing a controller. The system includes a first control arm and a second control arm. The system also includes an extrusion head located on a distal end of the second control arm. The controller is operable to adjust the first control arm to hold a distal end stead within a predetermined window of coordinates. The controller is also operable to position the second control arm such that the extrusion head is located according to the controller directions.

Abstract: A three-dimensional printing system including at least one positioning mechanism, and at least one end effector movably connected to the at least one positioning mechanism. The at least one end effector includes at least one mixing head configured to dispense a material, and at least one subtractive tool configured to subtract at least a portion of the material such that a desired design is achieved.

Abstract: A three-dimensional printing system including at least one positioning mechanism, and at least one end effector movably connected to the at least one positioning mechanism. The at least one end effector includes at least one mixing head configured to dispense a material, and at least one subtractive tool configured to subtract at least a portion of the material such that a desired design is achieved.

Abstract: An advertising system provides advertisements to client devices. To select advertisements, the advertising system identifies previously selected advertisements to determine which presentations of the advertisement are still in-flight and have not yet resulted in conversion event. The advertising system predicts total advertising spend based on the in-flight advertisements, and adjusts a paced bid for the advertisement by determining whether the estimated total advertising spend, reflecting predicted in-flight advertisements, is above or below an expected spending to reach a budget for the advertising campaign, which may increase or decrease the paced bid.

Abstract: A three-dimensional printing system including at least one positioning mechanism, and at least one end effector movably connected to the at least one positioning mechanism. The at least one end effector includes at least one mixing head configured to dispense a material, and at least one subtractive tool configured to subtract at least a portion of the material such that a desired design is achieved.

Abstract: An advertising system provides advertisements to client devices. To select advertisements, the advertising system identifies previously selected advertisements to determine which presentations of the advertisement are still in-flight and have not yet resulted in conversion event. The advertising system predicts total advertising spend based on the in-flight advertisements, and adjusts a paced bid for the advertisement by determining whether the estimated total advertising spend, reflecting predicted in-flight advertisements, is above or below an expected spending to reach a budget for the advertising campaign, which may increase or decrease the paced bid.