Patents by Inventor Cassady E. RUPERT

Cassady E. RUPERT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human In Vitro Cardiotoxicity Model
    Publication number: 20260086083
    Abstract: The Cardio-Tox Tissue Engineered Model (TEEM) invention provides a robust in vitro model for cardiotoxicity evaluation using three-dimensional (3D) human heart microtissues to quantify dose-dependent changes in electromechanical activity, resulting in a comprehensive cardiotoxicity and arrhythmia risk assessment of test compounds. The invention also provides a predictive in vitro screening platform for pro-arrhythmic toxicity testing using human three-dimensional cardiac microtissues. The invention enables the screening of environmental and pharmaceutical compounds, chemicals, and toxicants to establish safe human exposure levels.
    Type: Application
    Filed: September 24, 2025
    Publication date: March 26, 2026
    Inventors: Kareen L. K. Coulombe, Cassady E. Rupert, Celinda M. Kofron, Bum-Rak Choi, Taeyun Kim, Ulrike Mende
  • Human in vitro cardiotoxicity model
    Patent number: 12529694
    Abstract: The Cardio-Tox Tissue Engineered Model (TEEM) invention provides a robust in vitro model for cardiotoxicity evaluation using three-dimensional (3D) human heart microtissues to quantify dose-dependent changes in electromechanical activity, resulting in a comprehensive cardiotoxicity and arrhythmia risk assessment of test compounds. The invention also provides a predictive in vitro screening platform for pro-arrhythmic toxicity testing using human three-dimensional cardiac microtissues. The invention enables the screening of environmental and pharmaceutical compounds, chemicals, and toxicants to establish safe human exposure levels.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: January 20, 2026
    Assignees: Brown University, Rhode Island Hospital
    Inventors: Kareen L. K. Coulombe, Cassady E. Rupert, Celinda M. Kofron, Bum-Rak Choi, Taeyun Kim, Ulrike Mende
  • A HUMAN IN VITRO CARDIOTOXICITY MODEL
    Publication number: 20220205981
    Abstract: The Cardio-Tox Tissue Engineered Model (TEEM) invention provides a robust in vitro model for cardiotoxicity evaluation using three-dimensional (3D) human heart microtissues to quantify dose-dependent changes in electromechanical activity, resulting in a comprehensive cardiotoxicity and arrhythmia risk assessment of test compounds. The invention also provides a predictive in vitro screening platform for pro-arrhythmic toxicity testing using human three-dimensional cardiac microtissues. The invention enables the screening of environmental and pharmaceutical compounds, chemicals, and toxicants to establish safe human exposure levels.
    Type: Application
    Filed: May 18, 2020
    Publication date: June 30, 2022
    Inventors: Kareen L. K. COULOMBE, Cassady E. RUPERT, Celinda M. KOFRON, Bum-Rak CHOI, Taeyun KIM, Ulrike MENDE