Abstract: The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: A game for use by a plurality of players is disclosed. The game comprises a bag, a scoop for each player, a plurality of game pieces and a timer. In use, and in a starting arrangement of the game, the pieces are disposed in the bag. Each piece bears at least one visually-perceptible letter and a corresponding Braille representation of the letter. The pieces are sufficient in number such that, in use, and from the starting arrangement, each player can, in turn, manually-manipulate the scoop provided for the player to randomly withdraw from the bag a respective group of pieces, said group containing a sufficient number of game pieces to permit said pieces to be arranged in at least one subgroup wherein the letters of said pieces form a word. The timer demarcates a period of time in which each player can arrange the pieces to form words.