Abstract: A method for coating a medical device includes applying a second layer that includes a second drug on a first layer of on the medical device. The first layer includes a first drug, which may be in crystalline form. By selecting an appropriate solvent use in applying the second layer and appropriate process conditions, the second layer may be applied such that the first drug retains one or more therapeutic properties. For example, the second layer may be applied such that the first drug maintains its crystalline form. The first and second layers may be free of polymer.

Abstract: A variety of nanoparticles or microparticles may be used to treat diseases such as restenosis or blood clots. For example, a nanoparticle or microparticle may include a core having a biodegradable polymer, an exterior having hydrophilic moieties. and a therapeutic agent. The nanoparticles may include targeting moieties that target the nanoparticle or microparticle to an arterial lesion. The nanoparticle or microparticle may include an exterior shell around the core to increase stability of the nanoparticle or microparticle. The nanoparticle or microparticle may include a magnetic particle to allow targeted delivery of the nanoparticle or microparticle via a magnetic field. The nanoparticles or microparticles may be coated on a medical device, such as a catheter balloon or a stent, or may be delivered systemically or locally to patients in need thereof.

Abstract: In some examples, a medical device includes a flexible elongate member configured for navigation through vasculature of a patient to a target treatment site. A distal portion of the elongate member including a first balloon portion that is inflatable to an expanded state, a second balloon portion that is inflatable to an expanded state, and a cavitation generator. When the balloon portions are in their expanded states within the vasculature, a cavity is defined between the elongate member and the target treatment site and exterior to the first and second balloon portions. The cavitation generator is configured to deliver energy to a fluid within the cavity to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

Abstract: A method for coating a medical device includes applying a second layer that includes a second drug on a first layer of on the medical device. The first layer includes a first drug, which may be in crystalline form. By selecting an appropriate solvent use in applying the second layer and appropriate process conditions, the second layer may be applied such that the first drug retains one or more therapeutic properties. For example, the second layer may be applied such that the first drug maintains its crystalline form. The first and second layers may be free of polymer.

Abstract: A tissue-removing catheter includes a catheter body and a tissue-removing head. The catheter body has an annular shearing blade at the distal end thereof. The tissue-removing head is at the distal end of the catheter body and is configured to rotate about an head axis relative to the catheter body, and reciprocate along the head axis relative to the catheter body between proximal and distal positions.

Abstract: In some examples, a medical device includes a flexible elongate member configured for navigation through vasculature of a patient to a target treatment site. A distal portion of the elongate member including a first balloon portion that is inflatable to an expanded state, a second balloon portion that is inflatable to an expanded state, and a cavitation generator. When the balloon portions are in their expanded states within the vasculature, a cavity is defined between the elongate member and the target treatment site and exterior to the first and second balloon portions. The cavitation generator is configured to deliver energy to a fluid within the cavity to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

Abstract: A variety of nanoparticles or microparticles may be used to treat diseases such as restenosis or blood clots. For example, a nanoparticle or microparticle may include a core having a biodegradable polymer, an exterior having hydrophilic moieties. and a therapeutic agent. The nanoparticles may include targeting moieties that target the nanoparticle or microparticle to an arterial lesion. The nanoparticle or microparticle may include an exterior shell around the core to increase stability of the nanoparticle or microparticle. The nanoparticle or microparticle may include a magnetic particle to allow targeted delivery of the nanoparticle or microparticle via a magnetic field. The nanoparticles or microparticles may be coated on a medical device, such as a catheter balloon or a stent, or may be delivered systemically or locally to patients in need thereof.

Abstract: A tissue-removing catheter includes a catheter body and a tissue-removing head. The catheter body has an annular shearing blade at the distal end thereof. The tissue-removing head is at the distal end of the catheter body and is configured to rotate about an head axis relative to the catheter body, and reciprocate along the head axis relative to the catheter body between proximal and distal positions.