Abstract: A targeted temperature management (TTM) system is disclosed that includes a TTM module configured to provide a TTM fluid and a thermal pad configured to facilitate thermal energy transfer between the TTM fluid and a patient. The system further includes a fluid delivery line (FDL) coupled with the TTM module at a proximal end. A hub at the distal end of the FDL includes a delivery hub connector coupled with the delivery conduit connector, a return hub connector couples with the return conduit connector, and a locking mechanism is selectively configurable to alternate between a release configuration and a lock configuration. When the locking mechanism is in the lock configuration, it prevents at least one of separation of the delivery conduit connector from the delivery hub connector or separation of the return conduit connector from the return hub connector.