Patents by Inventor Catalin Barbacioru

Catalin Barbacioru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170362638
    Abstract: Disclosed are methods for determining copy number variation (CNV) known or suspected to be associated with a variety of medical conditions. In some embodiments, methods are provided for determining copy number variation (CNV) of fetuses using maternal samples comprising maternal and fetal cell free DNA. In some embodiments, methods are provided for determining CNVs known or suspected to be associated with a variety of medical conditions. Some embodiments disclosed herein provide methods to improve the sensitivity and/or specificity of sequence data analysis by deriving a fragment size parameter, such as a size-weighted coverage or a fraction of fragments in a size range. In some embodiments, the fragment size parameter is adjusted to remove within-sample GC-content bias. In some embodiments, removal of within-sample GC-content bias is based on sequence data corrected for systematic variation common across unaffected training samples.
    Type: Application
    Filed: December 11, 2015
    Publication date: December 21, 2017
    Inventors: Darya I. Chudova, Catalin Barbacioru, Sven Duenwald, David A. Comstock, Richard P. Rava
  • Publication number: 20170247759
    Abstract: The present disclosure provides methods for diagnosis of interstitial lung diseases (ILDs). The present disclosure provides methods for differential diagnosis of idiopathic pulmonary fibrosis from other ILDs. Compositions and kits useful in carrying out a subject method are also provided.
    Type: Application
    Filed: September 9, 2016
    Publication date: August 31, 2017
    Inventors: Jonathan I. WILDE, Sharlene VELICHKO, Catalin BARBACIORU, James DIGGANS, Giulia KENNEDY
  • Publication number: 20170220735
    Abstract: Disclosed are methods for determining copy number variation (CNV) known or suspected to be associated with a variety of medical conditions. In some embodiments, methods are provided for determining copy number variation of fetuses using maternal samples comprising maternal and fetal cell free DNA. In some embodiments, methods are provided for determining CNVs known or suspected to be associated with a variety of medical conditions. Some embodiments disclosed herein provide methods to improve the sensitivity and/or specificity of sequence data analysis by deriving a fragment size parameter. In some implementations, information from fragments of different sizes are used to evaluate copy number variations. In some implementations, one or more t-statistics obtained from coverage information of the sequence of interest is used to evaluate copy number variations. In some implementations, one or more fetal fraction estimates are combined with one or more t-statistics to determine copy number variations.
    Type: Application
    Filed: December 16, 2016
    Publication date: August 3, 2017
    Inventors: Sven Duenwald, David A. Comstock, Catalin Barbacioru, Darya I. Chudova, Richard P. Rava, Keith W. Jones, Gengxin Chen, Dimitri Skvortsov
  • Publication number: 20170103162
    Abstract: Methods for the determination of a copy number of a target genomic sequence; either a target gene or genomic sequence of interest, in a biological sample are described. Various methods utilize a model drawn from a probability density function (PDF) for the assignment of a copy number of a target genomic sequence in a biological sample. Additionally, the methods provide for the determination of a confidence value for a copy number assigned to a sample based on attributes of the sample data. Accordingly, the various methods for the determination of a copy number provide the end user with significant information for the evaluation of a copy number of a target genomic sequence; either a gene or genomic sequence of interest.
    Type: Application
    Filed: October 24, 2016
    Publication date: April 13, 2017
    Inventors: Harrison Leong, Catalin Barbacioru, Gordon Janaway
  • Publication number: 20160068915
    Abstract: Disclosed herein are kits, compositions, and methods relating to the classification of samples. Methods disclosed herein can also be used to diagnose conditions or to support treatment-related decisions.
    Type: Application
    Filed: September 11, 2015
    Publication date: March 10, 2016
    Inventors: Giulia C. Kennedy, Jonathan I. Wilde, Darya Chudova, Daniel Pankratz, Catalin Barbacioru, P. Sean Walsh, Moraima Pagan
  • Publication number: 20140378425
    Abstract: The present disclosure provides methods for diagnosis of interstitial lung diseases (ILDs). The present disclosure provides methods for differential diagnosis of idiopathic pulmonary fibrosis from other ILDs. Compositions and kits useful in carrying out a subject method are also provided.
    Type: Application
    Filed: March 14, 2014
    Publication date: December 25, 2014
    Applicant: Veracyte, Inc.
    Inventors: Jonathan I. Wilde, Sharlene Velichko, Catalin Barbacioru, James Diggans, Giulia Kennedy
  • Publication number: 20130006342
    Abstract: We hypothesized that gene expression patterns in peripheral blood cells may correlate with TAA disease status, and carried out a comprehensive gene expression survey on peripheral blood cells obtained from TAA patients and normal individuals. A distinct gene expression profile in peripheral blood cells can classify TAA patients from normal individuals. The genes provided by the present teachings define a set of diagnostic markers, thus providing a blood-based gene expression test to facilitate early detection of TAA disease. Methods of distinguishing ascending from descending TAA are also provided, as are methods of distinguishing familial from sporadic TAA.
    Type: Application
    Filed: September 12, 2012
    Publication date: January 3, 2013
    Applicant: Applied BioSystems, LLC
    Inventors: Yulei WANG, Catalin Barbacioru, Raymond R. Samaha, John A. Elefteriades
  • Publication number: 20100228496
    Abstract: Methods for the determination of a copy number of a target genomic sequence; either a target gene or genomic sequence of interest, in a biological sample are described. Various methods utilize a model drawn from a probability density function (PDF) for the assignment of a copy number of a target genomic sequence in a biological sample. Additionally, the methods provide for the determination of a confidence value for a copy number assigned to a sample based on attributes of the sample data. Accordingly, the various methods for the determination of a copy number provide the end user with significant information for the evaluation of a copy number of a target genomic sequence; either a gene or genomic sequence of interest.
    Type: Application
    Filed: March 9, 2010
    Publication date: September 9, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Harrison M. Leong, Catalin Barbacioru, Gordon A. Janaway
  • Publication number: 20090029868
    Abstract: We hypothesized that gene expression patterns in peripheral blood cells may correlate with TAA disease status, and carried out a comprehensive gene expression survey on peripheral blood cells obtained from TAA patients and normal individuals. A distinct gene expression profile in peripheral blood cells can classify TAA patients from normal individuals. The genes provided by the present teachings define a set of diagnostic markers, thus providing a blood-based gene expression test to facilitate early detection of TAA disease. Methods of distinguishing ascending from descending TAA are also provided, as are methods of distinguishing familial from sporadic TAA.
    Type: Application
    Filed: October 30, 2007
    Publication date: January 29, 2009
    Applicant: Applera Corporation
    Inventors: Yulei Wang, Catalin Barbacioru, Raymond R. Samaha, John A. Elefteriades