Abstract: Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise sulfoglucosamine sulfohydrolase (SGSH) enzyme-Fc fusion polypeptides. Certain embodiments also provide methods of using such proteins to treat Sanfilippo syndrome A.

Abstract: Certain embodiments provide a pharmaceutical composition comprising: a protein molecule comprising an ERT enzyme-Fc fusion polypeptide and a modified Fc polypeptide; a buffer; an isotonicity agent; a surfactant; and a stabilizer; wherein the pH of the pharmaceutical composition is about 5.5 to 7.0, as well as methods of use thereof.

Abstract: In one aspect, antibodies that specifically bind to a human triggering receptor expressed on myeloid cells 2 (TREM2) protein are provided. In some embodiments, the antibody decreases levels of soluble TREM2 (sTREM2). In some embodiments, the antibody enhances TREM2 activity.

Abstract: Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.

Abstract: Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.

Abstract: Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.

Abstract: Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.

Abstract: A collapsed ring fiber optic system includes a service path and a protection path provides at a shallow water portion of the fiber optic system, to deal with any fiber cuts that may occur at the shallow water portion without loss of main trunk bandwidth. The service and protection paths meet at a branch point, which is preferably located at a deep water portion of the fiber optic system. A passive combiner or a 1×2 switch is provided at the branch unit, along with a detector and a processor, to determine whether any signals are being received from the service path, and if not, to reconfigure the system to accept signals from the protection path. At another shallow water portion of the fiber optic system, nearby where a destination is located, the signal provided on the optical path over the deep water portion is split into a service path and a protection path, to provide redundancy to deal with any fiber cuts that may occur.

Abstract: A system and method of providing a transmission span for a telecommunications link based on a remote Er3+-doped fiber amplification scheme is provided, where a transmission span comprises first through third segments each respectively comprising first-third optical fibers having first-third fiber lengths and first-third physical properties. The first and third segments are optically coupled to opposing ends of the second segment. At least one of the first and third physical properties is different from the second physical property, where the first segment provides low nonlinearity, the third segment provides distributed gain, and the second segment compensates for the dispersion of the first and third segments. The span also includes a fourth optical fiber that is doped with a non-zero concentration of Er3+, and is disposed at a location in the span for remote pumping to provide discrete amplification of the optical signal.

Abstract: A system and method of providing a transmission span for a telecommunications link based on a remote Er3+-doped fiber amplification scheme is provided, where a transmission span comprises first through third segments each respectively comprising first-third optical fibers having first-third fiber lengths and first-third physical properties. The first and third segments are optically coupled to opposing ends of the second segment. At least one of the first and third physical properties is different from the second physical property, where the first segment provides low nonlinearity, the third segment provides distributed gain, and the second segment compensates for the dispersion of the first and third segments. The span also includes a fourth optical fiber that is doped with a non-zero concentration of Er3+, and is disposed at a location in the span for remote pumping to provide discrete amplification of the optical signal.

Abstract: A system and method of providing a transmission span that compensates for signal attenuation, dispersion, and nonlinearity of an optical signal communicated between two line units of a transmission link includes dividing the transmission span into a plurality of fiber segments and selecting a particular fiber for each of the segments. The fiber selection and arrangement of fibers within the span can be selected in accordance with the nonlinearity, dispersion conditions, and distributed gain conditions of the constituent fibers. In a three segment map, the first segment can provide low non linearity, the third segment can provide distributed gain, and the second segment can compensate for the dispersion of the first and third segments. The span can be used, e.g., for distributed Raman amplification. The span can alternatively include a two segment map, a four segment map, or a map with additional segments.

Abstract: A collapsed ring fiber optic system includes a service path and a protection path provides at a shallow water portion of the fiber optic system, to deal with any fiber cuts that may occur at the shallow water portion without loss of main trunk bandwidth. The service and protection paths meet at a branch point, which is preferably located at a deep water portion of the fiber optic system. A passive combiner or a 1×2 switch is provided at the branch unit, along with a detector and a processor, to determine whether any signals are being received from the service path, and if not, to reconfigure the system to accept signals from the protection path. At another shallow water portion of the fiber optic system, nearby where a destination is located, the signal provided on the optical path over the deep water portion is split into a service path and a protection path, to provide redundancy to deal with any fiber cuts that may occur.

Abstract: A collapsed ring fiber optic system includes a service path and a protection path provides at a shallow water portion of the fiber optic system, to deal with any fiber cuts that may occur at the shallow water portion without loss of main trunk bandwidth. The service and protection paths meet at a branch point, which is preferably located at a deep water portion of the fiber optic system. A passive combiner or a 1×2 switch is provided at the branch unit, along with a detector and a processor, to determine whether any signals are being received from the service path, and if not, to reconfigure the system to accept signals from the protection path. At another shallow water portion of the fiber optic system, nearby where a destination is located, the signal provided on the optical path over the deep water portion is split into a service path and a protection path, to provide redundancy to deal with any fiber cuts that may occur.

Abstract: A system and method of providing a transmission span that compensates for signal attenuation, dispersion, and nonlinearity of an optical signal communicated between two line units of a transmission link includes dividing the transmission span into a plurality of fiber segments and selecting a particular fiber for each of the segments. The fiber selection and arrangement of fibers within the span can be selected in accordance with the nonlinearity, dispersion conditions, and distributed gain conditions of the constituent fibers. In a three segment map, the first segment can provide low non linearity, the third segment can provide distributed gain, and the second segment can compensate for the dispersion of the first and third segments. The span can be used, e.g., for distributed Raman amplification. The span can alternatively include a two segment map, a four segment map, or a map with additional segments.

Abstract: A collapsed ring fiber optic system includes a service path and a protection path provides at a shallow water portion of the fiber optic system, to deal with any fiber cuts that may occur at the shallow water portion without loss of main trunk bandwidth. The service and protection paths meet at a branch point, which is preferably located at a deep water portion of the fiber optic system. A passive combiner or a 1×2 switch is provided at the branch unit, along with a detector and a processor, to determine whether any signals are being received from the service path, and if not, to reconfigure the system to accept signals from the protection path. At another shallow water portion of the fiber optic system, nearby where a destination is located, the signal provided on the optical path over the deep water portion is split into a service path and a protection path, to provide redundancy to deal with any fiber cuts that may occur.