Abstract: An active for use in the treatment or inhibition of an inflammatory disease associated with over-activation of Toll-like Receptor 4 (TLR4), Toll-like Receptor 2 (TLR2) and Myeloid differentiating protein 88 (Myd88) adaptor-like protein (Mal) while maintaining a subject's ability to respond normally to a pathogen, in which the active is an oleamide or an immunomodulatory analogue thereof.

Abstract: A detector circuit can include an integrator having an amplifier, a first feedback capacitor connected between an input and output of the amplifier, one or more additional feedback capacitors connected by at least one switch between the input and output of the amplifier, and a shunt capacitor connected to the output of the amplifier. The shunt capacitor can be selected to have a capacitance value greater than that of a minimum but less than that of a maximum feedback capacitance. The detector circuit can further include a sampling circuit having a sampling capacitor connected to the output of the integrator amplifier through at least one switch, wherein the sampling capacitor is separate from the shunt capacitor. A computed tomography imaging apparatus can include the detector circuit.

Abstract: A detector circuit can include an integrator having an amplifier, a first feedback capacitor connected between an input and output of the amplifier, one or more additional feedback capacitors connected by at least one switch between the input and output of the amplifier, and a shunt capacitor connected to the output of the amplifier. The shunt capacitor can be selected to have a capacitance value greater than that of a minimum but less than that of a maximum feedback capacitance. The detector circuit can further include a sampling circuit having a sampling capacitor connected to the output of the integrator amplifier through at least one switch, wherein the sampling capacitor is separate from the shunt capacitor. A computed tomography imaging apparatus can include the detector circuit.

Abstract: An amplifier system can include a feedback amplifier circuit having an amplifier, a feedback capacitor connected between an input terminal and an output terminal of the amplifier by at least one first switch, and a reset capacitor connected across the feedback capacitor by at least one second switch and between a pair of reference voltages by at least one third switch. During an input-signal processing phase of operation, a control circuit may close the at least one first switch and open the at least one second switch to electrically connect the feedback capacitor between the input and output terminals to engage feedback processing by the feedback amplifier circuit, and close the third switch to electrically connect the reset capacitor between the first and second voltages to charge the reset capacitor to a selectable voltage difference.

Abstract: An amplifier system can include a feedback amplifier circuit having an amplifier, a feedback capacitor connected between an input terminal and an output terminal of the amplifier by at least one first switch, and a reset capacitor connected across the feedback capacitor by at least one second switch and between a pair of reference voltages by at least one third switch. During an input-signal processing phase of operation, a control circuit may close the at least one first switch and open the at least one second switch to electrically connect the feedback capacitor between the input and output terminals to engage feedback processing by the feedback amplifier circuit, and close the third switch to electrically connect the reset capacitor between the first and second voltages to charge the reset capacitor to a selectable voltage difference.