Patents by Inventor Catherine A. Bothof
Catherine A. Bothof has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220334108Abstract: A composition and method of detecting an analyte in a sample using the composition, the composition including: a liquid that includes water; a plurality of first hollow glass bubbles in the liquid; a plurality of covalently attached first affinity groups that are covalently attached to at least some of the plurality of first hollow glass bubbles; and a plurality of first detector compound molecules not covalently bonded to the plurality of first hollow glass bubbles; wherein the first detector compound molecules include a first detectable group that is detected at a first wavelength; and wherein the first hollow glass bubbles have: a density of less than 0.60 gram/mole; a span of less than 1.0; and a plurality of covalently attached first affinity groups.Type: ApplicationFiled: September 24, 2020Publication date: October 20, 2022Inventors: Frederica Sgolastra, Stephen B. Roscoe, Daniel M. Dohmeier, Masayuki Nakamura, Catherine A. Bothof, Deniz Yuksel Yurt, David D. Johnson, Kyle A. Kalstabakken, Minghua Dai, Myungchan Kang, Neil Percy, Leslie M. Horton, Stephen M. Kennedy
-
Patent number: 11446613Abstract: An article that includes a functionalized copolymer and the use thereof, particularly in a process for binding biomaterials, such as in a process for separating aggregated proteins from monomeric proteins in a biological solution; wherein the article includes: a) a porous substrate; and b) a copolymer covalently attached to the porous substrate, the copolymer comprising a hydrocarbon backbone and a plurality of pendant groups attached to the hydrocarbon backbone, wherein 1) each of a first plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and 2) each of a second plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and wherein theType: GrantFiled: August 30, 2017Date of Patent: September 20, 2022Assignee: 3M Innovative Properties CompanyInventors: Andrew W. Vail, Semra Colak Atan, Jerald K. Rasmussen, George W. Griesgraber, Catherine A. Bothof
-
Publication number: 20220120649Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.Type: ApplicationFiled: December 27, 2021Publication date: April 21, 2022Inventors: Jerald K. Rasmussen, Catherine A. Bothof, George W. Griesgraber, Semra Colak Atan, James I. Hembre, Robert T. Fitzsimons, JR.
-
Patent number: 11279731Abstract: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.Type: GrantFiled: October 30, 2018Date of Patent: March 22, 2022Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Catherine A. Bothof, Kannan Seshadri, James I. Hembre, Robert T. Fitzsimons, Jr., George W. Griesgraber, Yi He
-
Patent number: 11237085Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.Type: GrantFiled: March 11, 2020Date of Patent: February 1, 2022Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Catherine A. Bothof, George W. Griesgraber, Semra Colak Atan, James I. Hembre, Robert T. Fitzsimons, Jr.
-
Publication number: 20210031152Abstract: An article that includes a functionalized copolymer and the use thereof, particularly in a process for binding biomaterials, such as in a process for separating aggregated proteins from monomeric proteins in a biological solution; wherein the article includes: a) a porous substrate; and b) a copolymer covalently attached to the porous substrate, the copolymer comprising a hydrocarbon backbone and a plurality of pendant groups attached to the hydrocarbon backbone, wherein 1) each of a first plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and 2) each of a second plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and wherein theType: ApplicationFiled: August 30, 2017Publication date: February 4, 2021Inventors: Andrew W. Vail, Semra Colak Atan, Jerald K. Rasmussen, George W. Griesgraber, Catherine A. Bothof
-
Patent number: 10851404Abstract: Luciferin-containing substrates are provided including a substrate and luciferin dried on the substrate. The luciferin-containing substrate is free of a detectable amount of reactive luciferase. The substrate is optionally a nonwoven substrate. Monitoring devices are also provided. The monitoring devices include a test element having a test portion, a detection reagent comprising luciferase, a luciferin-containing substrate, and a container having a first end with an opening and a second end opposite the first end. The container is configured to receive the test portion and configured to be operationally coupled to an analytical instrument. The detection reagent and the luciferin each are capable of participating in one or more chemical reaction that results in the formation of a detectable product.Type: GrantFiled: December 4, 2015Date of Patent: December 1, 2020Assignee: 3M Innovative Properties CompanyInventors: Hongying Jiang, Masayuki Nakamura, Xuan Jiang, Catherine A. Bothof
-
Publication number: 20200209123Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.Type: ApplicationFiled: March 11, 2020Publication date: July 2, 2020Inventors: Jerald K. Rasmussen, Catherine A. Bothof, George W. Griesgraber, Semra Colak Atan, James I. Hembre, Robert T. Fitzsimons, JR.
-
Patent number: 10627326Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.Type: GrantFiled: June 6, 2019Date of Patent: April 21, 2020Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Catherine A. Bothof, George W. Griesgraber, Semra Colak Atan, James I. Hembre, Robert T. Fitzsimons, Jr.
-
Publication number: 20200102345Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.Type: ApplicationFiled: December 4, 2019Publication date: April 2, 2020Inventors: Jerald K. Rasmussen, Kannan Seshadri, Robert T. Fitzimons, JR., James I. Hembre, Catherine A. Bothof, Erin A. Satterwhite, George W. Griesgraber, Yi He, Louis C. Haddad
-
Patent number: 10526366Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.Type: GrantFiled: May 23, 2018Date of Patent: January 7, 2020Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Kannan Seshadri, Robert T. Fitzsimons, Jr., James I. Hembre, Catherine A. Bothof, Erin A. Satterwhite, George W. Griesgraber, Yi He, Louis C. Haddad
-
Patent number: 10471398Abstract: Guanidinyl ligand-functionalized polymers, methods of making the same, and substrates bearing a grafted coating of the ligand-functional polymers are described. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, endotoxins and proteins, at pH's near or below the pI's of the biomaterials.Type: GrantFiled: February 28, 2017Date of Patent: November 12, 2019Assignee: 3M Innovative Properties CompanyInventors: Catherine A. Bothof, George W. Griesgraber, James I. Hembre, Jerald K. Rasmussen
-
Publication number: 20190285523Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.Type: ApplicationFiled: June 6, 2019Publication date: September 19, 2019Inventors: Jerald K. Rasmussen, Catherine A. Bothof, George W. Griesgraber, Semra Colak Atan, James I. Hembre, Robert T. Fitzsimons, JR.
-
Patent number: 10352835Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.Type: GrantFiled: March 27, 2018Date of Patent: July 16, 2019Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Catherine A. Bothof, George W. Griesgraber, Semra Colak Atan, James I. Hembre, Robert T. Fitzsimons, Jr.
-
Publication number: 20190194250Abstract: A process for separating aggregated proteins from monomeric proteins in a biological solution, the process including: providing at least one filter element having a contacting surface, wherein the filter element comprises filter media comprising: a porous substrate; and disposed on the porous substrate, a polymer comprising a hydrocarbon backbone and a plurality of pendant groups attached to the hydrocarbon backbone, wherein each of a first plurality of pendant groups comprises: (1) at least one acidic group or salt thereof; and (2) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and allowing an initial biological solution to contact the contacting surface of the filter element N under conditions effective to separate the aggregated proteins from the monomeric proteins such that a final biological solution includes purified monomeric proteins.Type: ApplicationFiled: August 30, 2017Publication date: June 27, 2019Inventors: Semra Colak Atan, Andrew W. Vail, Jerald K. Rasmussen, George W. Griesgraber, Catherine A. Bothof
-
Publication number: 20190062369Abstract: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.Type: ApplicationFiled: October 30, 2018Publication date: February 28, 2019Inventors: Jerald K. Rasmussen, Catherine A. Bothof, Kannan Seshadri, James I. Hembre, Robert T. Fitzsimons, JR., George W. Griesgraber, Yi He
-
Patent number: 10144760Abstract: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.Type: GrantFiled: February 8, 2016Date of Patent: December 4, 2018Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Catherine A. Bothof, Kannan Seshadri, James I. Hembre, Robert T. Fitzsimons, Jr., George W. Griesgraber, Yi He
-
Publication number: 20180265542Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.Type: ApplicationFiled: May 23, 2018Publication date: September 20, 2018Inventors: Jerald K. Rasmussen, Kannan Seshadri, Robert T. Fitzimons, JR., James I. Hembre, Catherine A. Bothof, Erin A. Satterwhite, George W. Griesgraber, Yi He, Louis C. Haddad
-
Publication number: 20180217035Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.Type: ApplicationFiled: March 27, 2018Publication date: August 2, 2018Inventors: Jerald K. Rasmussen, Catherine A. Bothof, George W. Griesgraber, Semra Colak Atan, James I. Hembre, Robert T. Fitzsimons, JR.
-
Patent number: 10017461Abstract: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.Type: GrantFiled: April 12, 2017Date of Patent: July 10, 2018Assignee: 3M Innovative Properties CompanyInventors: Catherine A. Bothof, Yi He, Jerald K. Rasmussen, Kannan Seshadri, Clinton P. Waller, Jr., Douglas E. Weiss