Abstract: The invention relates to a recombinant lentiviral vector genome comprising a polynucleotide encoding a fusion polypeptide, wherein said fusion protein comprises arranged from N-terminal to C-terminal ends: (i) a first polypeptide comprising a multimerization scaffold which comprises at least one collectin or a fragment thereof suitable to enable self-assembly of multimers of the first polypeptide, fused with at least one antigenic polypeptide; (ii) a second polypeptide comprising a CD40L ectodomain or a receptor binding fragment thereof, in particular the CD40L ectodomain of the human CD40L. The invention also relates to a lentiviral vector and pharmaceutical compositions comprising it.

Abstract: The invention relates to Plasmodium antigenic polypeptides identified through the use of a specifically devised functional immunization screening assay. In particular, the invention relates to antigenic polypeptides of malaria parasites wherein said antigenic polypeptides that exhibit a protective effect, especially that of eliciting a protective immune response in a host against challenge by Plasmodium sporozoites. The invention relates to a combination of compounds, comprising at least 2 distinct active ingredients wherein each active ingredient consists of an antigenic polypeptide of a Plasmodium parasite, a polynucleotide encoding the antigenic polypeptide, or a vector, in particular a viral vector, especially a lentiviral vector, expressing such antigenic polypeptide of a Plasmodium parasite, wherein one antigenic polypeptide is the circumsporozoite protein (CSP) or a polypeptidic derivative thereof and another antigenic polypeptide is either protein Ag40 (11-09) or protein Ag45 (11-10).

Abstract: The invention relates to chimeric Plasmodium antigenic polypeptides derived from pre-erythrocytic (PE) antigens and associated in a fusion polypeptide. In particular, the invention relates to antigenic fusion polypeptides of malaria parasites wherein said antigenic polypeptides exhibit a protective effect, especially that of eliciting a protective immune response in a host against challenge by Plasmodium sporozoites or a sterile response. Such identified antigenic fusion polypeptides may thus constitute active ingredients suitable for the design of a vaccine candidate, in particular a vaccine suitable for a human host.

Abstract: An in-line method for marking a substrate made of extruded synthetic material, the method including the steps of extruding the synthetic material through an extrusion die to form the substrate, marking the substrate by scrolling the substrate obtained from the extrusion die between two rotatably mounted and temperature-controlled rollers with an upper roller and a lower roller, one of the rollers having an impression forming the negative of a decoration or a texture to be marked on one face of the substrate, this same roller or the other of the rollers including at least one notch allowing to guide the substrate as it passes through the extrusion die and between the two rollers. An installation can include in line the extrusion die and the marking device.

Abstract: A method of fabrication of a wristband of a watch or piece of jewelry, including: providing a first synthetic material; providing an extrusion line with a die plate for making an extrudate from the first material; providing one or more additional materials distinguished in their properties from the first material; providing a die plate including a first zone defining a profile allowing for fabrication of an extrudate having a hollow tubular profile at least at one of its ends in which the extrudate has a width corresponding to the length of one or two strands of the wristband; the die plate further includes a second zone allowing defining of particular profiles selected from among a flat profile, a curved profile, or a profile with projecting zones.

Abstract: The invention relates to Plasmodium antigenic polypeptides identified through the use of a specifically devised functional immunization screening assay. In particular, the invention relates to antigenic polypeptides of malaria parasites wherein said antigenic polypeptides that exhibit a protective effect, especially that of eliciting a protective immune response in a host against challenge by Plasmodium sporozoites. The invention relates to a combination of compounds, comprising at least 2 distinct active ingredients wherein each active ingredient consists of an antigenic polypeptide of a Plasmodium parasite, a polynucleotide encoding the antigenic polypeptide, or a vector, in particular a viral vector, especially a lentiviral vector, expressing such antigenic polypeptide of a Plasmodium parasite, wherein one antigenic polypeptide is the circumsporozoite protein (CSP) or a polypeptidic derivative thereof and another antigenic polypeptide is either protein Ag40 (11-09) or protein Ag45 (11-10).

Abstract: A method of fabrication of a wristband of a watch or piece of jewelry, including: providing a first synthetic material; providing an extrusion line with a die plate for making an extrudate from the first material; providing one or more additional materials distinguished in their properties from the first material; providing a die plate including a first zone defining a profile allowing for fabrication of an extrudate having a hollow tubular profile at least at one of its ends in which the extrudate has a width corresponding to the length of one or two strands of the wristband; the die plate further includes a second zone allowing defining of particular profiles selected from among a flat profile, a curved profile, or a profile with projecting zones.

Abstract: A method for producing a flexible pouch made of flexible thermoplastic material, including steps of: (i) preparing hot flexible thermoplastic material in a pasty state, (ii) placing a so-called “proximal” pre-molded insert onto a mounting such that the insert is arranged in a ring around the mounting, (iii) coating all or part of the insert with hot flexible thermoplastic material in the pasty state, (iv) locking the blow-mold shells around the insert, and (v) injecting a pressurized gas into the chamber so as to expand the sleeve from inside onto the inner surface of the mold or expand the sleeve from the outside by creating negative pressure inside the chamber.