Patents by Inventor Catherine C. Y. Chang

Catherine C. Y. Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITION AND METHOD FOR ATTENUATING NEUROINFLAMMATION, AMYLOIDOPATHY AND TAUOPATHY
    Publication number: 20220257544
    Abstract: The present invention features compositions and methods for preventing or treating neuroinflammation, amyloidopathy or tauopathy by inhibiting Acyl-CoA:Cholesterol Acyltransferase activity, in particular with brain-permeable inhibitors encapsulated in a stealth liposome-based nanoparticle. Stealth liposome-based nanoparticles for reducing or attenuating amyloidopathy or tauopathy are also provided.
    Type: Application
    Filed: April 18, 2022
    Publication date: August 18, 2022
    Inventors: Ta Yuan CHANG, Catherine C.Y. CHANG, Haibo LI, Adrianna DE LA TORRE, Thao N. HUYNH
  • Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
    Patent number: 10100308
    Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA: Cholesterol Acyltransferase 1, but not Acyl-CoA: Cholesterol Acyltransferase 2.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: October 16, 2018
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang, Yohei Shibuya, Zhaoyang Niu
  • Method for selectively inhibiting ACAT1 in the treatment of obesity, metabolic syndrome, and atherosclerosis
    Patent number: 9856478
    Abstract: The present invention features methods for preventing and treating three related diseases, diet-induced obesity, metabolic syndrome, and atherosclerosis, alone or in combination by inhibiting Acyl-CoA:Cholesterol Acyltransferase 1 (ACATI) activity or expression in myeloid cells.
    Type: Grant
    Filed: September 10, 2014
    Date of Patent: January 2, 2018
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang, Li-Hao Huang, Elaina Melton, Paul Sohn
  • METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20170292128
    Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA: Cholesterol Acyltransferase 1, but not Acyl-CoA: Cholesterol Acyltransferase 2.
    Type: Application
    Filed: May 28, 2015
    Publication date: October 12, 2017
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang, Yohei Shibuya, Zhaoyang Niu
  • METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF OBESITY, METABOLIC SYNDROME, AND ATHEROSCLEROSIS
    Publication number: 20160355824
    Abstract: The present invention features methods for preventing and treating three related diseases, diet-induced obesity, metabolic syndrome, and atherosclerosis, alone or in combination by inhibiting Acyl-CoA: Cholesterol Acyltransferase 1 (ACATI) activity or expression in myeloid cells.
    Type: Application
    Filed: September 10, 2014
    Publication date: December 8, 2016
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang, Li-Hao Huang, Elaina Melton, Paul Sohn
  • Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
    Patent number: 9388414
    Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: July 12, 2016
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang, Yohei Shibuya, Zhaoyang Niu
  • Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
    Patent number: 9388413
    Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: July 12, 2016
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang, Yohei Shibuya, Zhaoyang Niu
  • Methods for treating Niemann-Pick type C disease
    Patent number: 9206425
    Abstract: The present invention includes methods for treating Niemann-Pick Type C disease through administration of inhibitors of acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1). ACAT inhibitors are used to treat symptoms of Niemann-Pick Type C disease and prolong survival of patients with the disease, either alone or in combination with other treatments.
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: December 8, 2015
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang, Maximillian A. Rogers
  • Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease
    Patent number: 9149492
    Abstract: The present invention features methods for stimulating clearance of amyloid beta in microglia, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: October 6, 2015
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang, Yohei Shibuya, Elena Bryleva, Stephanie Murphy, Maximillian A. Rogers
  • METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20150079161
    Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Application
    Filed: November 21, 2014
    Publication date: March 19, 2015
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang, Yohei Shibuya, Zhaoyang Niu
  • METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20140308340
    Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Application
    Filed: May 29, 2014
    Publication date: October 16, 2014
    Applicant: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang, Yohei Shibuya, Zhaoyang Niu
  • Method for selectively inhibiting the activity of ACAT1 in the treatment of alzheimer's disease
    Patent number: 8802646
    Abstract: The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: August 12, 2014
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang, Elena Bryleva, Stephanie Murphy, Maximillian A. Rogers
  • METHODS FOR TREATING NIEMANN-PICK TYPE C DISEASE
    Publication number: 20140220114
    Abstract: The present invention includes methods for treating Niemann-Pick Type C disease through administration of inhibitors of acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1). ACAT inhibitors are used to treat symptoms of Niemann-Pick Type C disease and prolong survival of patients with the disease, either alone or in combination with other treatments.
    Type: Application
    Filed: July 24, 2012
    Publication date: August 7, 2014
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang, Maximillian A. Rogers
  • METHODS FOR TREATING IMMUNOSUPPRESSION
    Publication number: 20140170210
    Abstract: The present invention includes methods for increasing white blood cell counts through administration of inhibitors of acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1). ACAT inhibitors are used to treat symptoms of immunosuppression, either alone or in combination with other treatments.
    Type: Application
    Filed: August 2, 2012
    Publication date: June 19, 2014
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang, Paul Li-Hao Huang
  • Methods for identifying allosteric and other novel acyl-coenzyme A:cholesterol acyltransferase inhibitors
    Patent number: 8673587
    Abstract: The present invention is a method for identifying compounds that are allosteric and/or other novel ACAT inhibitors that is based on the novel finding that pregnenolone is a substrate for ACAT; esterification of pregnenolone by ACAT is dramatically activated when cholesterol is present in the assay. The method comprises measuring the esterification of pregnenolone by ACAT under two different conditions: with cholesterol, or without cholesterol. This method can be used to test and categorize various candidate ACAT inhibitors as allosteric or other novel ACAT inhibitors, or it can be used in high-throughput screening for identifying such ACAT inhibitors.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: March 18, 2014
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang
  • METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20140044757
    Abstract: The present invention features methods for stimulating clearance of amyloid beta in microglia, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Application
    Filed: September 11, 2013
    Publication date: February 13, 2014
    Applicant: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang, Yohei Shibuya, Elena Bryleva, Stephanie Murphy, Maximillian A. Rogers
  • Method of selectively inhibiting the activity of ACAT1 in the treatment of Alzheimer's disease
    Patent number: 8466121
    Abstract: The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: June 18, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang
  • Methods for Identifying Allosteric and Other Novel Acyl-Coenzyme A:Cholesterol Acyltransferase Inhibitors
    Publication number: 20130040327
    Abstract: The present invention is a method for identifying compounds that are allosteric and/or other novel ACAT inhibitors that is based on the novel finding that pregnenolone is a substrate for ACAT; esterification of pregnenolone by ACAT is dramatically activated when cholesterol is present in the assay. The method comprises measuring the esterification of pregnenolone by ACAT under two different conditions: with cholesterol, or without cholesterol. This method can be used to test and categorize various candidate ACAT inhibitors as allosteric or other novel ACAT inhibitors, or it can be used in high-throughput screening for identifying such ACAT inhibitors.
    Type: Application
    Filed: May 3, 2011
    Publication date: February 14, 2013
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang
  • Method for Selectively Inhibiting the Activity of ACAT1 in the Treatment of Alzheimer's Disease
    Publication number: 20130017252
    Abstract: The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Application
    Filed: September 6, 2012
    Publication date: January 17, 2013
    Applicant: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang
  • Method of Selectively Inhibiting the Activity of ACAT1 in the Treatment of Alzheimer's Disease
    Publication number: 20110237656
    Abstract: The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Application
    Filed: March 28, 2011
    Publication date: September 29, 2011
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: TA-YUAN CHANG, CATHERINE C.Y. CHANG