Abstract: The present invention relates to a Cucumis melo seed designated 34-777 RZ. The present invention also relates to a Cucumis melo plant produced by growing the 34-777 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-777 RZ.

Abstract: The present invention relates to a Cucumis melo seed designated 34-758 RZ. The present invention also relates to a Cucumis melo plant produced by growing the 34-758 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-758 RZ.

Abstract: The present invention relates to a Cucumis melo seed designated 34-749 RZ. The present invention also relates to a Cucumis melo plant produced by growing the 34-749 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-749 RZ.

Abstract: The present invention relates to a Cucumis melo seed designated 34-758 RZ. The present invention also relates to a Cucumis melo plant produced by growing the 34-758 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-758 RZ.

Abstract: The present invention relates to a Cucumis melo seed designated 34-777 RZ. The present invention also relates to a Cucumis melo plant produced by growing the 34-777 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-777 RZ.

Abstract: The present invention relates to a Cucumis melo seed designated 34-742 RZ. The present invention also relates to a Cucumis melo plant produced by growing the 34-742 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-742 RZ.

Abstract: The present invention relates to a Cucumis melo seed designated 34-749 RZ. The present invention also relates to a Cucumis melo plant produced by growing the 34-749 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-749 RZ.

Abstract: The present invention relates to a Cucumis melo seed designated 34-742 RZ. The present invention also relates to a Cucumis melo plant produced by growing the 34-742 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-742 RZ.

Abstract: The present invention relates to a Cucumis melo seed designated 34-765 RZ, which may exhibit a medium to dark greyish green color of the young fruit, a circular fruit shape in longitudinal section, a green ground color of the fruit skin with medium intensity and a yellowish hue, a small to medium size of the pistil scar, a reddish orange flesh color, and intermediate resistance to powdery mildew Podosphaera xanthii (Px) race 1, race 2, race 5. The present invention also relates to a Cucumis melo plant produced by growing the 34-765 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-765 RZ.

Abstract: The present invention relates to a Cucumis melo seed designated 34-780 RZ, which may exhibit andromonoecious sex expression, a circular to slightly broad elliptic shape in longitudinal section, a very light to light intensity of the grey ground color of the fruit skin, a small to medium size of the pistil scar, a medium thickness of the cork layer with a linear and netted pattern of a medium density, medium time of ripening, a long to very long shelf life, and intermediate resistance to powdery mildew Podosphaera xanthii (Px) race 1, race 2, race 5. The present invention also relates to a Cucumis melo plant produced by growing the 34-780 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-780 RZ.

Abstract: The present invention relates to a Cucumis melo seed designated 34-757 RZ, which may exhibit a medium intense greyish green young fruit color, a medium fruit length, a circular fruit shape in longitudinal section, orange main flesh color, and intermediate resistance to powdery mildew Podosphaera xanthii (Px) race 1, race 2, race 5. The present invention also relates to a Cucumis melo plant produced by growing the 34-757 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-757 RZ.

Abstract: The present invention addresses limitations of prior art receptor-based traps through a methodology called the clamp/click/cleave (CCC) approach. Two fusion proteins each comprising a binding domain fused to a coiled-coil are non-covalently dimerized through the coiled-coil (clamp), and the dimer so formed is stabilized by a covalent disulphide bond (click) between cysteine residues located on the fusion proteins between the binding domains and coiled-coils. Once the disulphide bond has formed, the coiled-coils are subsequently removed (cleave) by cleaving the fusions proteins at cleavage sites located between the cysteine residues and the coiled-coils to provide the covalently dimerized bivalent binding agent of the present invention. Such binding agents are useful in the treatment and diagnosis of disease states characterized by production and/or overexpression of a ligand to which the binding domains bind.

Abstract: The present invention relates to a Cucumis melo seed designated 34-309 RZ, which may exhibit small leaves with erect to semi-erect petioles, a yellow ground color of the fruit skin, fruits that have a medium rate of change of fruit color from maturity to overmaturity, resistance to aphids (Aphis gossypii), intermediate resistance to powdery mildew Podosphaera xanthii (Px) race 1, race 2, race 5, intermediate resistance to powdery mildew Golovinomyces cichoracearum (Gc) race 1. The present invention also relates to a Cucumis melo plant produced by growing the 34-309 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-309 RZ.

Abstract: The present invention relates to a Cucumis melo seed designated 34-757 RZ, which may exhibit a medium intense greyish green young fruit color, a medium fruit length, a circular fruit shape in longitudinal section, orange main flesh color, and intermediate resistance to powdery mildew Podosphaera xanthii (Px) race 1, race 2, race 5. The present invention also relates to a Cucumis melo plant produced by growing the 34-757 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-757 RZ.

Abstract: The present invention relates to a Cucumis melo seed designated 34-765 RZ, which may exhibit a medium to dark greyish green color of the young fruit, a circular fruit shape in longitudinal section, a green ground color of the fruit skin with medium intensity and a yellowish hue, a small to medium size of the pistil scar, a reddish orange flesh color, and intermediate resistance to powdery mildew Podosphaera xanthii (Px) race 1, race 2, race 5. The present invention also relates to a Cucumis melo plant produced by growing the 34-765 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-765 RZ.

Abstract: The present invention relates to a Cucumis melo seed designated 34-780 RZ, which may exhibit andromonoecious sex expression, a circular to slightly broad elliptic shape in longitudinal section, a very light to light intensity of the grey ground color of the fruit skin, a small to medium size of the pistil scar, a medium thickness of the cork layer with a linear and netted pattern of a medium density, medium time of ripening, a long to very long shelf life, and intermediate resistance to powdery mildew Podosphaera xanthii (Px) race 1, race 2, race 5. The present invention also relates to a Cucumis melo plant produced by growing the 34-780 RZ seed. The invention further relates to methods for producing the melon cultivar, represented by melon variety 34-780 RZ.

Abstract: The invention provides hetero-multivalent ligand binging agents (traps) for members of the TGF-? superfamily, as well as methods for making and using such constructs. In an embodiment of the invention there is provided a hetero-multivalent binding agent with affinity for a member of the TGF-? superfamily. The agent comprises the general structure I: (<bd1>-linker1)k-[{<bd1>-linker2-<bd2>-linker3f-}n-(<bd3>)m-(linker4-<bd4>)d]h, where bd1, bd2, bd3 and bd4 are polypeptide binding domains having an affinity for different sites on the same member or for different members of the TGF-? superfamily; at least two of bd1, bd2, bd3, and bd4 are different from each other.

Abstract: The present invention addresses limitations of prior art receptor-based traps through a methodology called the clamp/click/cleave (CCC) approach. Two fusion proteins each comprising a binding domain fused to a coiled-coil are non-covalently dimerized through the coiled-coil (clamp), and the dimer so formed is stabilized by a covalent disulphide bond (click) between cysteine residues located on the fusion proteins between the binding domains and coiled-coils. Once the disulphide bond has formed, the coiled-coils are subsequently removed (cleave) by cleaving the fusions proteins at cleavage sites located between the cysteine residues and the coiled-coils to provide the covalently dimerized bivalent binding agent of the present invention. Such binding agents are useful in the treatment and diagnosis of disease states characterized by production and/or overexpression of a ligand to which the binding domains bind.

Abstract: The invention provides hetero-multivalent ligand binging agents (traps) for members of the TGF-? superfamily, as well as methods for making and using such constructs. In an embodiment of the invention there is provided a hetero-multivalent binding agent with affinity for a member of the TGF-? superfamily, said agent comprising the general structure (I): (<bd1>-linker1)k-[{<bd1>-linker2-<bd2>-linker3r-}n-(<bd3>)m-(linker4-<bd4>)d]h, where bd1, bd2, bd3 and bd4 are polypeptide binding domains having an affinity for different sites on the same member or for different members of the TGF-? superfamily, wherein at least two of bd1, bd2, bd3, and bd4 are different from each other.

Abstract: An angle indicating device is provided for measuring the angle of an X-ray machine and to display the angle on the photographic plate at the time it is exposed to X-rays. The invention includes the combination of a pendulum mounted to maintain a vertical orientation during rotation of the X-ray machine about its horizontal axis, and an indicator for indicating the angle of the X-ray machine relative to a vertical orientation of the pendulum. Furthermore, a scale and a scale indicator, both of which are opaque to X-rays is provided to project the read out of the angle indicator upon the photographic plate.