Patents by Inventor Catherine Dubertret

Catherine Dubertret has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transfecting compounds which are sensitive to reducing conditions, pharmaceutical compositions containing them and their applications
    Patent number: 6521252
    Abstract: The invention concerns a novel agent for transferring nucleic acids into cells. Said agent is particularly characterised in that it comprises one or several disulphide bonds sensitive to reducing conditions. The invention also concerns compositions comprising such an agent for transferring in vivo, ex vivo or in vitro nucleic acids of interest into different cell types.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: February 18, 2003
    Assignee: Aventis Pharma S.A.
    Inventors: Gérardo Byk, Catherine Dubertret, Bruno Pitard, Daniel Scherman
  • Compounds, preparation and use for transferring nucleic acids into cells
    Patent number: 6300321
    Abstract: The invention concerns compounds for transferring nucleic acids into cells. The compounds are more particularly related to the lipopolyamine family, and comprise amidine functions. The compounds are useful for transferring nucleic acids of interest into various cellular types, in vitro, in vivo, or ex vivo.
    Type: Grant
    Filed: December 15, 1999
    Date of Patent: October 9, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: Daniel Scherman, Catherine Dubertret, Gerardo Byk
  • Lipopolyamines as transfection agents and pharmaceutical uses thereof
    Patent number: 6171612
    Abstract: Lipopolyamines useful for the transfection of nucleic acid and methods of preparation thereof are disclosed. The lipopolyamines are of general formula I, in which R4 comprises at least one C10-C22 aliphatic radical.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: January 9, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: G{acute over (e)}rardo Byk, Daniel Scherman, Bertrand Schwartz, Catherine Dubertret
  • Lipopolyamines as transfection agents and pharamaceutical uses thereof
    Patent number: 6107286
    Abstract: Cationic lipids of general formula (I), wherein m is an integer from 2 to 6 inclusive; n is an integer from 1 to 9 inclusive, preferably 1-5, where, when n is 2-9, a single R grouping other than hydrogen is present in the general formula, and m has variable or identical values within the groupings (a) or --(CH.sub.2).sub.m ; R is a hydrogen atom or a radical of general formula (II), wherein X or X.sup.1, which are the same or different, are an oxygen atom, a methylene grouping --(CH.sub.2).sub.q -- where q is 0, 1, 2 or 3, or an amino grouping --NH-- or NR.sup.1 --, where R is a C.sub.1-4 alkyl grouping; Y and Y.sup.1, which are the same or different, are a hydrogen atom or an optionally substituted C.sub.1-4 alkyl radical, and p is 0-5; and R.sub.6 is a cholesterol derivative or an alkylamino grouping --NR.sub.1 R.sub.2, where R.sub.1 and R.sub.2 are, independently of each other, a straight or branched, saturated or unsaturated C.sub.12-22 aliphatic radical.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: August 22, 2000
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Gerardo Byk, Daniel Scherman, Catherine Dubertret
  • Intermediates of peptide antagonists of neurotensin
    Patent number: 5747303
    Abstract: The invention is directed to a novel compound of formula ##STR1## in which R is a hydroxyl, alkyloxy, phenylalkyloxy or --NH--CH.sub.2 --COOH radical, R' and R" are identical and are each a hydroxy or methoxy radical and R'" represents a hydrogen, bromine, chlorine or iodine atom or a nitro radical. The invention is also directed to the salts of said compounds and their use.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: May 5, 1998
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Jacques Debernard, Catherine Dubertret, Gerard Helynck, Jean Leboul, Jean-Paul Martin