Patents by Inventor Catherine E. Lofton-Day

Catherine E. Lofton-Day has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND NUCLEIC ACIDS FOR THE DETECTION OF COLORECTAL CELL PROLIFERATIVE DISORDERS
    Publication number: 20220260570
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: February 1, 2022
    Publication date: August 18, 2022
    Inventors: Catherine E. Lofton-Day, Matthias Ebert
  • METHODS AND NUCLEIC ACIDS FOR ANALYSES OF CELLULAR PROLIFERATIVE DISORDERS
    Publication number: 20220154287
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: October 28, 2021
    Publication date: May 19, 2022
    Inventors: Catherine E. LOFTON-DAY, Andrew Z. SLEDZIEWSKI, Ralf LESCHE, Matthias SCHUSTER, Juergen DISTLER, Reimo TETZNER, Thomas HILDMANN, Fabian MODEL, Xiaoling SONG
  • Methods and nucleic acids for analyses of cellular proliferative disorders
    Patent number: 11186879
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: November 30, 2021
    Assignee: EPIGENOMICS AG
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • METHODS AND NUCLEIC ACIDS FOR ANALYSES OF CELLULAR PROLIFERATIVE DISORDERS
    Publication number: 20190316210
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 17, 2019
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Methods and nucleic acids for analyses of cellular proliferative disorders
    Patent number: 10385402
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 20, 2019
    Assignee: EPIGENOMICS AG
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • METHODS AND NUCLEIC ACIDS FOR ANALYSES OF CELLULAR PROLIFERATIVE DISORDERS
    Publication number: 20190119760
    Abstract: The invention provides methods, nucleic acids and kits for detecting colorectal cell proliferative disorders based on underexpression or methylation of a least one gene selected from RASSF2, TFAP2E, SNDI, PCDHGC3, EDNRB, STOM, GLI3, RXFP3, LimK1, GPR73L1, PCDH1O, DOCKIO and MRPS21, and optionally Septin-9.
    Type: Application
    Filed: September 26, 2018
    Publication date: April 25, 2019
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Fabian Model, Susan Cottrell, Juergen Distler, Reimo Tetzner, Dimo Dietrich
  • Methods and nucleic acids for analyses for cellular proliferative disorders
    Patent number: 9939441
    Abstract: Provided herein are methods, nucleic acids and kits for detecting a cell proliferative disorder. Also provided herein are genomic sequences of RASSF?-2, the methylation patterns of which have utility for the improved detection of cell proliferative disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: April 10, 2018
    Assignee: EPIGENOMICS AG
    Inventors: Dimo Dietrich, Catherine E. Lofton-Day, Shannon Payne
  • Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
    Patent number: 9850532
    Abstract: The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: December 26, 2017
    Assignee: EPIGENOMICS AG
    Inventors: Andrew Z. Sledziewski, Catherine E. Lofton-Day, Reimo Tetzner, Juergen Distler, Fabian Model, Shannon Payne
  • Methods and nucleic acids for the analyses of cellular proliferative disorders
    Patent number: 9695478
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: July 4, 2017
    Assignee: EPIGENOMICS AG
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
    Patent number: 9605306
    Abstract: The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: March 28, 2017
    Assignee: EPIGENOMICS AG
    Inventors: Andrew Z. Sledziewski, Catherine E. Lofton-Day, Reimo Tetzner, Juergen Distler, Fabian Model, Shannon Payne, Dimo Dietrich
  • METHODS AND NUCLEIC ACIDS FOR THE ANALYSIS OF GENE EXPRESSION ASSOCIATED WITH THE DEVELOPMENT OF PROSTATE CELL PROLIFERATIVE DISORDERS
    Publication number: 20170067120
    Abstract: The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: August 17, 2016
    Publication date: March 9, 2017
    Inventors: Andrew Z. Sledziewski, Catherine E. Lofton-Day, Reimo Tetzner, Juergen Distler, Fabian Model, Shannon Payne, Dimo Dietrich
  • METHODS AND NUCLEIC ACIDS FOR ANALYSES OF CELLULAR PROLIFERATIVE DISORDERS
    Publication number: 20160304964
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: March 23, 2016
    Publication date: October 20, 2016
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • METHODS AND NUCLEIC ACIDS FOR THE ANALYSIS OF GENE EXPRESSION ASSOCIATED WITH THE DEVELOPMENT OF PROSTATE CELL PROLIFERATIVE DISORDERS
    Publication number: 20140227700
    Abstract: The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: April 28, 2014
    Publication date: August 14, 2014
    Applicant: EPIGENOMICS AG
    Inventors: Andrew Z. Sledziewski, Catherine E. Lofton-Day, Reimo Tetzner, Juergen Distler, Fabian Model, Shannon Payne, Dimo Dietrich
  • METHODS AND NUCLEIC ACIDS FOR THE ANALYSES OF CELLULAR PROLIFERATIVE DISORDERS
    Publication number: 20110039719
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: May 13, 2010
    Publication date: February 17, 2011
    Applicant: EPIGENOMICS AG
    Inventors: CATHERINE E. LOFTON-DAY, ANDREW Z. SLEDZIEWSKI, RALF LESCHE, MATTHIAS SCHUSTER, JUERGEN DISTLER, REIMO TETZNER, THOMAS HILDMANN, FABIAN MODEL, XIAOLING SONG
  • METHODS AND NUCLEIC ACIDS FOR THE ANALYSIS OF GENE EXPRESSION ASSOCIATED WITH THE DEVELOPMENT OF PROSTATE CELL PROLIFERATIVE DISORDERS
    Publication number: 20100203514
    Abstract: The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: November 26, 2007
    Publication date: August 12, 2010
    Inventors: Andrew Z. Sledziewski, Catherine E. Lofton-Day, Reimo Tetzner, Juergen Distler, Fabian Model, Shannon Payne, Dimo Dietrich
  • Methods and nucleic acids for the analyses of cellular proliferative disorders
    Patent number: 7749702
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: July 6, 2010
    Assignee: Epigenomics AG
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • METHODS AND NUCLEIC ACIDS FOR ANALYSES OF CELLULAR PROLIFERATIVE DISORDERS
    Publication number: 20100143902
    Abstract: The invention provides methods, nucleic acids and kits for detecting colorectal cell proliferative disorders based on underexpression or methylation of a least one gene selected from RASSF2, TFAP2E, SND1, PCDHGC3, EDNRB, STOM, GLI3, RXFP3, LimK1, GPR73L1, PCDH1O, DOCKIO and MRPS21, and optionally Septin-9. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: July 23, 2007
    Publication date: June 10, 2010
    Applicant: Epigenomics AG
    Inventors: Catherine E Lofton-Day, Andrew Z. Sledziewski, Fabian Model, Susan Cottrell, Juergen Distler, Reimo Tetzner, Dimo Dietrich
  • METHODS AND NUCLEIC ACIDS FOR ANALYSES FOR CELLULAR PROLIFERATIVE DISORDERS
    Publication number: 20100092953
    Abstract: The invention provides methods, nucleic acids and kits for detecting a cell proliferative disorder. The invention discloses genomic sequences of RASSF-2 the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: July 23, 2007
    Publication date: April 15, 2010
    Applicant: EPIGENOMICS AG
    Inventors: Dimo Dietrich, Catherine E. Lofton-Day, Shannon Payne
  • UMLR polypeptides
    Patent number: 7217790
    Abstract: Novel secreted and membrane bound tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate inflammation, tumor growth and metastasis, infection, immunity, and cellular maturation.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: May 15, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Wenfeng Xu, Catherine E. Lofton-Day, Randal M. Henne, Scott R. Presnell, Yue Yao, Julia E. Novak
  • Antibodies that bind testis-specific insulin homolog polypeptides
    Patent number: 7070774
    Abstract: The present invention provides testis-specific insulin homolog polypeptides and polynucleotides encoding the polypeptides, as well as related compositions and methods are disclosed. The polypeptides and polynucleotides may be used within methods for enhancing viability of cryopreserved sperm, for enhancing sperm motility, to enhance fertilization in methods of assisted reproduction, as contraceptives and other related uses.
    Type: Grant
    Filed: November 3, 2003
    Date of Patent: July 4, 2006
    Assignee: ZymoGenetics, Inc.
    Inventors: Si Lok, Darrell C. Conklin, Catherine E. Lofton-Day, Stephen R. Jaspers, Michael R. Stamm