Abstract: A print chip includes: an elongate silicon substrate defining nominal leading and trailing longitudinal sides of the print chip; circuitry layers positioned on the silicon substrate; and a MEMS layer positioned on the circuitry layers. The MEMS layer includes a plurality of parallel nozzle rows, each nozzle row having a plurality of inkjet nozzle devices arranged in a main row portion and a dropped row portion offset from the main row portion. The circuitry layers include data latches configured to provide dot data for the inkjet nozzle devices. A first row of data latches is positioned adjacent a leading row of the main row portion, and a second row of data latches is positioned adjacent a trailing row of the dropped row portion.

Abstract: A method of printing an image from a printhead module having a plurality of horizontal nozzle rows. Each nozzle row has a main row portion and a corresponding dropped row portion vertically offset from the main row portion. The method includes the steps of: determining a predetermined delay for the dropped row portions based on the offset, a print speed and a print resolution; allocating dot data for image lines to respective nozzle rows based on the print speed and print resolution, sending first dot data for each main row portion and second dot data for each dropped row portion to the printhead module; and firing nozzles from the main row portions and dropped row portion in a predetermined sequence. Each dropped row portion is fired independently of its corresponding main row portion and delayed relative to its corresponding main row portion by the predetermined delay.

Abstract: A method of printing an image from a printhead module having a plurality of horizontal ink planes M supplied with a same ink. Each ink plane has a nozzle row and the nozzles rows of all ink planes have vertically aligned nozzles. The method includes the steps of: defining contiguous span groups along each nozzle row, each span group containing N nozzles; allocating dot data for each image line of the image to a predetermined number of nozzles P in each span group of each nozzle row; sending the dot data to the printhead module and firing nozzles sequentially from the ink planes to print the image line. Only one nozzle from each span group in a same nozzle row is fired simultaneously, N is an integer multiple of M, and P is N divided by M.

Abstract: The present invention relates to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

Abstract: The present invention relates to systems, methods and devices for metabolomic-based classification of biological samples, and interpretation methods for biomarker discovery.

Abstract: A method of printing an image from a printhead module having a plurality of horizontal nozzle rows. Each nozzle row has a main row portion and a corresponding dropped row portion vertically offset from the main row portion. The method includes the steps of: determining a predetermined delay for the dropped row portions based on the offset, a print speed and a print resolution; allocating dot data for image lines to respective nozzle rows based on the print speed and print resolution, sending first dot data for each main row portion and second dot data for each dropped row portion to the printhead module; and firing nozzles from the main row portions and dropped row portion in a predetermined sequence. Each dropped row portion is fired independently of its corresponding main row portion and delayed relative to its corresponding main row portion by the predetermined delay.

Abstract: A method of printing an image from a printhead module having a plurality of horizontal ink planes M supplied with a same ink. Each ink plane has a nozzle row and the nozzles rows of all ink planes have vertically aligned nozzles. The method includes the steps of: defining contiguous span groups along each nozzle row, each span group containing N nozzles; allocating dot data for each image line of the image to a predetermined number of nozzles P in each span group of each nozzle row; sending the dot data to the printhead module and firing nozzles sequentially from the ink planes to print the image line. Only one nozzle from each span group in a same nozzle row is fired simultaneously, N is an integer multiple of M, and P is N divided by M.

Abstract: A print chip includes: an elongate silicon substrate defining nominal leading and trailing longitudinal sides of the print chip; circuitry layers positioned on the silicon substrate; and a MEMS layer positioned on the circuitry layers. The MEMS layer includes a plurality of parallel nozzle rows, each nozzle row having a plurality of inkjet nozzle devices arranged in a main row portion and a dropped row portion offset from the main row portion. The circuitry layers include data latches configured to provide dot data for the inkjet nozzle devices. A first row of data latches is positioned adjacent a leading row of the main row portion, and a second row of data latches is positioned adjacent a trailing row of the dropped row portion.

Abstract: The present invention relates to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

Abstract: The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

Abstract: A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

Abstract: A needle-free adaptor for removing liquid from a vial comprises a cannula adapted to piece a septum of a vial, a plurality of legs surrounding the cannula to secure the adaptor to the vial when the cannula has pieced the septum, an elastomeric membrane having a normally closed pinhole orifice, and a conforming surface having an orifice connected to the cannula. The elastomeric membrane has a stable convex shape and is adapted to receive a nozzle of a needle-free device. Pressed against the elastomeric membrane, the nozzle deflects the elastomeric membrane from the convex shape to an unstable or pseudo-stable inverted position against the conforming surface. Buckling of the elastomeric membrane opens the pinhole orifice and enables fluid communication between the vial and the nozzle by interfacing the pinhole orifice with the orifice on the conforming surface.

Abstract: A debridement device having a controllable Lorentz-force actuator is disclosed. The debridement device includes a nozzle delivering a jet of debridement substance to a tissue and the jet is driven by the Lorentz-force actuator. The device may have a suction port for removing the debridement substance. A second Lorentz-force actuator can be used for each of the jet and suction. The first and second Lorentz-force actuators for the jet and suction can also be configured to provide for continuous jet injection and continuous suction. The device may include a second nozzle delivering a second jet of debridement substance to the region of tissue and the first and second jets may intersect and dissipate into a mist upon intersection to dissipate the kinetic energy of the jets. The Lorentz-force actuator may drive a reciprocating piston pump providing continuous pressure to the nozzles.

Abstract: The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

Abstract: The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

Abstract: A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.

Abstract: A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

Abstract: A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

Abstract: A method for testing the effect of a skin care product includes measuring a mechanical property of skin tissue using nonlinear stochastic system identification, applying the product to the skin, repeating the measurement of the mechanical property after the application of the product, and comparing the before and after measurements to quantify the effect of the product. Measuring the mechanical property of the skin can include placing a probe against a surface of the skin, perturbing the skin with the probe using a stochastic sequence, and measuring the response of the skin to the perturbation. Perturbing the skin can include indenting the skin with the probe, extending the skin with the probe, and sliding the probe across the skin surface. The mechanical property may be indicative of skin compliance, skin elasticity, skin stiffness, or skin damping. The mechanical property can be dependent on perturbation depth and may be measured at a plurality of anatomical locations.

Abstract: A debridement device having a controllable Lorentz-force actuator is disclosed. The debridement device includes a nozzle delivering a jet of debridement substance to a tissue and the jet is driven by the Lorentz-force actuator. The device may have a suction port for removing the debridement substance. A second Lorentz-force actuator can be used for each of the jet and suction. The first and second Lorentz-force actuators for the jet and suction can also be configured to provide for continuous jet injection and continuous suction. The device may include a second nozzle delivering a second jet of debridement substance to the region of tissue and the first and second jets may intersect and dissipate into a mist upon intersection to dissipate the kinetic energy of the jets. The Lorentz-force actuator may drive a reciprocating piston pump providing continuous pressure to the nozzles.