Abstract: Disclosed are controls for use in identifying any of a number of genotypes and/or for use in identifying or characterizing a disease or condition. The controls may be particularly useful for diagnostic tests that utilize circulating cell-free DNA or microRNA. A control may comprise a mixture of nucleic acids. In some embodiments, a control comprises liposomes, e.g., wherein nucleic acids of the control are associated with the liposomes. For example, the controls are useful for determining whether a fetus comprises an aneuploidy. Also disclosed are methods of using the controls.

Abstract: Disclosed are controls for use in identifying any of a number of genotypes and/or for use in identifying or characterizing a disease or condition. The controls may be particularly useful for diagnostic tests that utilize circulating cell-free DNA or microRNA. A control may comprise a mixture of nucleic acids. In some embodiments, a control comprises liposomes, e.g., wherein nucleic acids of the control are associated with the liposomes. For example, the controls are useful for determining whether a fetus comprises an aneuploidy. Also disclosed are methods of using the controls.

Abstract: Disclosed are compositions and methods related to replication deficient Sindbis viruses that are able to function as controls for nucleic acid diagnostic assays (e.g., nucleic acid sequencing based assays and/or nucleic acid amplification based assays).

Abstract: Disclosed are compositions and methods related to replication deficient adenoviruses that are able to function as controls for nucleic acid diagnostic assays (e.g., nucleic acid sequencing based assays and/or nucleic acid amplification based assays).

Abstract: Disclosed are nucleic acids comprising a plurality of nucleotide sequences, wherein each nucleotide sequence corresponds to a genotype. The nucleic acids are useful for developing biological reference materials comprising a number of different genotypes.

Abstract: Disclosed are nucleic acids, comprising a plurality of nucleotide sequences, and each nucleotide sequence of the plurality comprises a genotype that is associated with a disease or condition. For example, each nucleotide sequence of the plurality may be a human nucleotide sequence, and each genotype may be a somatic mutation that is associated with a neoplasm or a heart condition (e.g., cardiomyopathy). Also disclosed are cells comprising the nucleic acid, e.g., wherein the cell is a human cell. A related biological reference material comprises a plurality of cells comprising the nucleic acid, and a plurality of cells that do not comprise the nucleic acid (e.g., untransfected cells). The cells of the reference material may be fixed (e.g., with formalin) or embedded in paraffin.

Abstract: Disclosed are compositions and methods related to replication deficient Sindbis viruses that are able to function as controls for nucleic acid diagnostic assays (e.g., nucleic acid sequencing based assays and/or nucleic acid amplification based assays).

Abstract: Disclosed are controls for use in identifying any of a number of genotypes and/or for use in identifying or characterizing a disease or condition. The controls may be particularly useful for diagnostic tests that utilize circulating cell-free DNA or microRNA. A control may comprise a mixture of nucleic acids. In some embodiments, a control comprises liposomes, e.g., wherein nucleic acids of the control are associated with the liposomes. For example, the controls are useful for determining whether a fetus comprises an aneuploidy. Also disclosed are methods of using the controls.