Patents by Inventor Catherine Jorand

Catherine Jorand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic Compounds as IRAK1/4 Inhibitors and Uses Thereof
    Publication number: 20170275284
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: June 12, 2017
    Publication date: September 28, 2017
    Inventors: Xiaoling CHEN, Henry YU, Ruoxi LAN, Catherine JORAND-LEBRUN, Theresa L. JOHNSON, Andreas GOUTOPOULOS
  • Macrocyclic compounds as IRAK1/4 inhibitors and uses thereof
    Patent number: 9708324
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: July 18, 2017
    Assignee: Merck Patent GmbH
    Inventors: Xiaoling Chen, Henry Yu, Ruoxi Lan, Catherine Jorand-Lebrun, Theresa L. Johnson, Andreas Goutopoulos
  • ALPHA-AMINO ESTERS OF HYDROXYPROPYLTHIAZOLIDINE CARBOXAMIDE DERIVATIVE AND SALT FORM, CRYSTAL POLYMORPH THEREOF
    Publication number: 20170190677
    Abstract: The invention provides ?-amino esters of a hydroxypropylthiazolidine carboxamide derivative, (2S)-3-([1,1?-biphenyl]-4-ylsulfonyl)-N-[(1S)-3-hydroxy-1-phenylpropyl]-1,3-thiazolidine-2-carboxamide, as well as salts and crystal polymorph s thereof, that can be used to inhibit prostaglandin F receptor. The invention further encompasses methods of treating disorders such as pre-term labor at the early gestational stage by the administration of these substances to a patient in need of treatment.
    Type: Application
    Filed: August 8, 2016
    Publication date: July 6, 2017
    Inventors: Patrick Naxos PAGE, Matthias SCHWARZ, Catherine JORAND-LEBRUN, Anna QUATTROPANI, Vincent POMEL
  • PYRIDAZINONE MACROCYCLES AS IRAK INHIBITORS AND USES THEREOF
    Publication number: 20170173019
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: March 6, 2017
    Publication date: June 22, 2017
    Inventors: Xiaoling CHEN, Ruoxi LAN, Catherine JORAND-LEBRUN, Henry YU, Andreas GOUTOPOULOS
  • MACROCYCLIC PYRIDAZINONE DERIVATIVES
    Publication number: 20170143713
    Abstract: A compound of formula (I) is provided: wherein R1, R2, R3, R4, L and Z have the meaning given in the claims. Further provided is the prophylaxis and treatment of diseases with the compound of formula (I).
    Type: Application
    Filed: November 30, 2016
    Publication date: May 25, 2017
    Applicant: Merck Patent GmbH
    Inventors: Catherine JORAND-LEBRUN, Santosh KULKARNI, Serge CHRISTMANN-FRANCK
  • Pyridazinone macrocycles as IRAK inhibitors and uses thereof
    Patent number: 9624246
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: April 18, 2017
    Assignee: Merck Patent GmbH
    Inventors: Xiaoling Chen, Ruoxi Lan, Catherine Jorand-Lebrun, Henry Yu, Andreas Goutopoulos
  • HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF
    Publication number: 20170081307
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: September 16, 2016
    Publication date: March 23, 2017
    Inventors: Catherine JORAND-LEBRUN, Ruoxi LAN, Austin CHEN, Ryan C. CLARK
  • HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF
    Publication number: 20170081317
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: September 16, 2016
    Publication date: March 23, 2017
    Inventors: Catherine JORAND-LEBRUN, Ruoxi LAN, Austin CHEN, Ryan C. Clark
  • PYRIDAZINONE-AMIDES DERIVATIVES
    Publication number: 20170071936
    Abstract: The present invention relates to compounds of formula (I) wherein R1, Ra, Rb and Z have the meaning given in claim 1, and their use in the prophylaxis and treatment of diseases.
    Type: Application
    Filed: November 23, 2016
    Publication date: March 16, 2017
    Applicant: Merck Patent GmbH
    Inventors: Catherine JORAND-LEBRUN, Santosh KULKARNI, Stefano CROSIGNANI
  • Pyridazinone-amides derivatives
    Patent number: 9567320
    Abstract: The present invention relates to compounds of formula (I) wherein R1, Ra, Rb and Z have the meaning given in claim 1, and their use in the prophylaxis and treatment of diseases.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: February 14, 2017
    Assignee: MERCK PATENT GmbH
    Inventors: Catherine Jorand-Lebrun, Santosh Kulkarni, Stefano Crosignani
  • Macrocyclic pyridazinone derivatives
    Patent number: 9550794
    Abstract: The present invention relates to compounds of formula (I) Wherein R1, R2, R3, R4, L and Z have the meaning given in claim 1, and their use in the prophylaxis and treatment of diseases.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: January 24, 2017
    Assignee: MERCK PATENT GmbH
    Inventors: Catherine Jorand-Lebrun, Santosh Kulkarni, Serge Christmann-Franck
  • ?-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
    Patent number: 9447055
    Abstract: The invention provides ?-amino esters of a hydroxypropylthiazolidine carboxamide derivative, (2S)-3-([1,1?-biphenyl]-4-ylsulfonyl)-N-[(1S)-3-hydroxy-1-phenylpropyl]-1,3-thiazolidine-2-carboxamide, as well as salts and crystal polymorphs thereof, that can be used to inhibit prostaglandin F receptor. The invention further encompasses methods of treating disorders such as pre-term labor at the early gestational stage by the administration of these substances to a patient in need of treatment.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: September 20, 2016
    Assignee: Merck Serono S.A.
    Inventors: Patrick Naxos Page, Matthias Schwarz, Catherine Jorand-Lebrun, Anna Quattropani, Vincent Pomel
  • PYRIDAZINONE MACROCYCLES AS IRAK INHIBITORS AND USES THEREOF
    Publication number: 20160229871
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: February 5, 2016
    Publication date: August 11, 2016
    Inventors: Xiaoling CHEN, Ruoxi LAN, Catherine JORAND-LEBRUN, Henry YU, Andreas GOUTOPOULOS
  • Macrocyclic Compounds as IRAK1/4 Inhibitors and Uses Thereof
    Publication number: 20160229856
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: February 5, 2016
    Publication date: August 11, 2016
    Inventors: Xiaoling CHEN, Henry YU, Ruoxi LAN, Catherine JORAND-LEBRUN, Theresa L. JOHNSON, Andreas GOUTOPOULOS
  • HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF
    Publication number: 20160145252
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
    Type: Application
    Filed: November 19, 2015
    Publication date: May 26, 2016
    Inventors: Catherine JORAND-LEBRUN, Reinaldo JONES, Annie Cho WON, Ngan NGUYEN, Theresa L. JOHNSON, Lizbeth Celeste DESELM, Kausik PANDA
  • PYRIDAZINONE-AMIDES DERIVATIVES
    Publication number: 20150376167
    Abstract: The present invention relates to compounds of formula (I) wherein R1, Ra, Rb and Z have the meaning given in claim 1, and their use in the prophylaxis and treatment of diseases.
    Type: Application
    Filed: February 6, 2014
    Publication date: December 31, 2015
    Applicant: Merck Patent GmbH
    Inventors: Catherine JORAND-LEBRUN, Santosh KULKARNI, Stefano CROSIGNANI
  • MACROCYCLIC PYRIDAZINONE DERIVATIVES
    Publication number: 20150376206
    Abstract: The present invention relates to compounds of formula (I) Wherein R1, R2, R3, R4, L and Z have the meaning given in claim 1, and their use in the prophylaxis and treatment of diseases.
    Type: Application
    Filed: February 7, 2014
    Publication date: December 31, 2015
    Applicant: Merck Patent GmbH
    Inventors: Catherine JORAND-LEBRUN, Santosh KULKARNI, Serge CHRISTMANN-FRANCK
  • Pyrimidine pyrazolyl derivatives
    Patent number: 9216991
    Abstract: The present invention provides compounds of Formula (I) for the treatment of cancer, rheumatoid arthritis and other diseases.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: December 22, 2015
    Assignee: Ares Trading S.A.
    Inventors: Stefano Crosignani, Catherine Jorand-Lebrun, Patrick Gerber, Mathilde Muzerelle
  • Indazolyl triazol derivatives
    Patent number: 9073892
    Abstract: Compounds of Formula (I) are used for the treatment of inflammation and autoimmune disorders.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: July 7, 2015
    Assignee: Merck Serono S.A.
    Inventors: Catherine Jorand-Lebrun, Stefano Crosignani, Jerome Dorbais, Tania Grippi-Vallotton, Adeline Pretre
  • PYRIMIDINE PYRAZOLYL DERIVATIVES
    Publication number: 20150141396
    Abstract: The present invention provides compounds of Formula (I) for the treatment of cancer, rheumatoid arthritis and other diseases.
    Type: Application
    Filed: July 3, 2013
    Publication date: May 21, 2015
    Applicant: Ares Trading S.A.
    Inventors: Stefano Crosignani, Catherine Jorand-Lebrun, Patrick Gerber, Mathilde Muzerelle