Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

Abstract: A system for modifying a load map of a worksite includes one or more processing circuits. The one or more processing circuits include one or more memory devices coupled to one or more processors. The one or more memory devices are configured to store instructions thereon that, when executed by the one or more processors, cause the one or more processors to receive a load indication regarding a load of a work machine, generate a modified load map based on the load map and the load where the modified load map includes an acceptable zone defining an acceptable load threshold and a warning zone defining a warning load threshold, receive a location indication regarding a location of the work machine on the worksite, and provide a warning when the work machine is within or approaching the warning zone.

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

Abstract: Systems and methods are disclosed for processes related to cell culture and generation. A system for culturing cells comprises a cell culture container comprising a first surface, the first surface being configured for one or more cell colonies to adhere thereto; an image sensor configured to capture one or more time-series images of a first cell colony in the one or more cell colonies; a computing subsystem configured to iteratively manage a surface area of the first cell colony according to a method comprising: calculating the surface area of the first cell colony as the first cell colony proliferates, selecting a portion of the first cell colony to remove to reduce the surface area of the first cell colony when its surface area is above a predetermined threshold, and removing, using a cell removal tool, the selected portion of the first cell colony from the first surface.

Abstract: Systems and methods are disclosed for processes related to cell culture and generation. A system for culturing cells a cell culture container comprises a first surface, the first surface being configured for a plurality of cell colonies to continuously adhere thereto throughout a cell culture process; an image sensor configured to capture one or more time-series images of the plurality of cell colonies during the cell culture process; a cell removal tool configured to remove one or more cells from the first surface of the cell culture container during the cell culture process; and a computing subsystem configured to: track one or more characteristics of the plurality of cell colonies based on the one or more time-series images, and control the cell removal tool to remove cells based on the one or more characteristics.

Abstract: Systems and methods are disclosed for processes related to cell culture and generation.

Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

Abstract: Systems and apparatuses include a load map interface system including one or more processing circuits comprising one or more memory devices coupled to one or more processors, the one or more memory devices configured to store instructions thereon that, when executed by the one or more processors, cause the one or more processors to: receive a load map from an external input; determine a work machine load based at least in part on a sensor array of a work machine; generate a modified load map based on the received load map and the work machine load, the modified load map including an acceptable zone defining an acceptable load threshold and a warning zone defining a warning zone threshold; determine a location of the work machine on the modified load map; and send a notification to a display indicating that the work machine is within the acceptable zone or the warning zone.

Abstract: An apparatus is provided that executes instructions to move an item within a scan zone to specific X-Y coordinates of the scan zone. The item is placed on a platform and is rotated 360 degrees at each X-Y coordinate within the scan zone. Item images are captured by cameras at each X-Y coordinate and for each rotation at the corresponding X-Y coordinate. The item images are labeled and retained. The item images are used as input to a Machine-Learning Model (MLM) to train the MLM to recognize item codes for the items when subsequent images are captured for the item during a checkout. In an embodiment, during a checkout unknown item images are flagged and labeled with the corresponding item code when the corresponding item's barcode is scanned during the checkout; the labeled item images are also retailed for training the MLM for item recognition.

Abstract: Disclosed are novel detectable imaging agents that can bind to a novel biomarker for cancer and methods of their use in the resection of a tumor.

Abstract: The present disclosure provides an apixaban film product for treatment and prevention of thrombosis and related disorders. Also provided is a method of making the film product. The film product comprises an anticoagulant and a hydrophilic cellulosic polymer.

Abstract: Features are described for controlling the functionality of an electronic device, where the device operates according to a restricted mode of operation in which functions that the electronic device is otherwise capable of performing are not immediately available.

Abstract: Systems and apparatuses include a load map interface system including one or more processing circuits comprising one or more memory devices coupled to one or more processors, the one or more memory devices configured to store instructions thereon that, when executed by the one or more processors, cause the one or more processors to: receive a load map from an external input; determine a work machine load based at least in part on a sensor array of a work machine; generate a modified load map based on the received load map and the work machine load, the modified load map including an acceptable zone defining an acceptable load threshold and a warning zone defining a warning zone threshold; determine a location of the work machine on the modified load map; and send a notification to a display indicating that the work machine is within the acceptable zone or the warning zone.

Abstract: An electronic device changes the current user interface of a respective type of user interface from a first user interface to a second user interface. An individual uses their personal device to set up and configure a device for another user.

Abstract: A fast acting orally disintegrating film (ODF) for treatment of various medical conditions including emesis that has a simple formulation, easy to manufacture and has similar pharmacokinetic profile to currently commercially available orally administered drug products is provided. The ODF comprises an active pharmaceutical ingredient such as ondansetron or a pharmaceutical acceptable salt thereof in an amount of 2 to 24 mg, at least one hydrophilic film forming polymer in an amount of at least 8% by weight of the film, wherein the at least one hydrophilic film forming polymer is characterized by having a molecular weight of 5000 to 50000 Da, and a water soluble excipient in an amount of 10 to 30% by weight of the film.

Abstract: An electronic device changes the current user interface of a respective type of user interface from a first user interface to a second user interface. An individual uses their personal device to set up and configure a device for another user.

Abstract: A pramipexole transdermal patch for treatment of neurological disorders including Parkinson's disease that may be administered on a daily basis. The pramipexole transdermal patch of the present invention preferably comprises a drug-containing layer that comprises pramipexole or a pharmaceutically acceptable salt thereof at 2% to about 15% by weight of the drug-containing layer and at least two acrylic polymers wherein each polymer may further comprise carboxyl and/or hydroxyl functional groups. The pramipexole transdermal patch of the present invention may further comprise two or more permeation enhancers with combined pramipexole solubility of great than 50 mg/mL.

Abstract: The present invention relates to transdermal drug delivery system of pharmaceutical compositions, which have a satisfactory in-vitro performance and good bioavailability. In particular, the transdermal pharmaceutical composition of clobazam in the present invention includes a micro-emulsion in liquid or semi solid form, in a dosage form adapted for transdermal delivery (e.g., transdermal patch) for treatment of certain types of epilepsy and anxiety for continues application.

Abstract: Disclosed are anti-cancer compounds and imaging agents. More specifically, the disclosed agents target carbonic anhydrase IX and XII and their use in the treatment of cancer, in particular breast cancer. Specific compounds are those that have Formula II wherein R1 and R2 are each independently chosen from (CH2)nC?CH and, L is a linking moiety; n is 1-8; m is 0-8; each X is independently chosen from R3, OR3, NH2, NHR3, and; and each R3 is independently chosen from a detectable moiety or targeting moiety, with the proviso that R1 and R2 are not both (CH2)4C?CH.

Abstract: The present invention relates to transdermal drug delivery system of pharmaceutical compositions, which have a satisfactory in-vitro performance and good bioavailability. In particular, the transdermal pharmaceutical composition of clobazam in the present invention includes a micro-emulsion in liquid or semi solid form, in a dosage form adapted for transdermal delivery (e.g., transdermal patch) for treatment of certain types of epilepsy and anxiety for continues application.