Abstract: The present disclosure provides, among other things, methods for treating cancer comprising administering an effective dose of azenosertib, or a pharmaceutically acceptable salt thereof, to subjects selected to have a homologous recombination repair deficiency (HRD).

Abstract: An apparatus is provided that executes instructions to move an item within a scan zone to specific X-Y coordinates of the scan zone. The item is placed on a platform and is rotated 360 degrees at each X-Y coordinate within the scan zone. Item images are captured by cameras at each X-Y coordinate and for each rotation at the corresponding X-Y coordinate. The item images are labeled and retained. The item images are used as input to a Machine-Learning Model (MLM) to train the MLM to recognize item codes for the items when subsequent images are captured for the item during a checkout. In an embodiment, during a checkout unknown item images are flagged and labeled with the corresponding item code when the corresponding item's barcode is scanned during the checkout; the labeled item images are also retailed for training the MLM for item recognition.

Abstract: Features are described for controlling the functionality of an electronic device, where the device operates according to a restricted mode of operation in which functions that the electronic device is otherwise capable of performing are not immediately available.

Abstract: A worksite system includes a non-transitory computer-readable storage medium having instructions stored thereon. The instructions, upon execution by one or more processors, cause the one or more processors to: acquire a plurality of load indications regarding a plurality of loads of a plurality of work machines on a worksite, acquire a plurality of locations of the plurality of work machines on the worksite, determine a warning zone on the worksite based on the plurality of plurality of loads and the plurality of locations, and at least one of: provide a warning to a respective work machine of the plurality of work machines when the respective work machine is within or approaches the warning zone, or at least partially limit operation of the respective work machine when the respective work machine is within or approaches the warning zone.

Abstract: A system for modifying a load map of a worksite includes one or more processing circuits. The one or more processing circuits include one or more memory devices coupled to one or more processors. The one or more memory devices are configured to store instructions thereon that, when executed by the one or more processors, cause the one or more processors to receive a load indication regarding a load of a work machine, generate a modified load map based on the load map and the load where the modified load map includes an acceptable zone defining an acceptable load threshold and a warning zone defining a warning load threshold, receive a location indication regarding a location of the work machine on the worksite, and provide a warning when the work machine is within or approaching the warning zone.

Abstract: The present disclosure provides an apixaban film product for treatment and prevention of thrombosis and related disorders. Also provided is a method of making the film product. The film product comprises an anticoagulant and a hydrophilic cellulosic polymer.

Abstract: The present disclosure provides an apixaban film product for treatment and prevention of thrombosis and related disorders. Also provided is a method of making the film product. The film product comprises an anticoagulant and a hydrophilic cellulosic polymer.

Abstract: A system for modifying a load map of a worksite includes one or more processing circuits. The one or more processing circuits include one or more memory devices coupled to one or more processors. The one or more memory devices are configured to store instructions thereon that, when executed by the one or more processors, cause the one or more processors to receive a load indication regarding a load of a work machine, generate a modified load map based on the load map and the load where the modified load map includes an acceptable zone defining an acceptable load threshold and a warning zone defining a warning load threshold, receive a location indication regarding a location of the work machine on the worksite, and provide a warning when the work machine is within or approaching the warning zone.

Abstract: Systems and apparatuses include a load map interface system including one or more processing circuits comprising one or more memory devices coupled to one or more processors, the one or more memory devices configured to store instructions thereon that, when executed by the one or more processors, cause the one or more processors to: receive a load map from an external input; determine a work machine load based at least in part on a sensor array of a work machine; generate a modified load map based on the received load map and the work machine load, the modified load map including an acceptable zone defining an acceptable load threshold and a warning zone defining a warning zone threshold; determine a location of the work machine on the modified load map; and send a notification to a display indicating that the work machine is within the acceptable zone or the warning zone.

Abstract: An apparatus is provided that executes instructions to move an item within a scan zone to specific X-Y coordinates of the scan zone. The item is placed on a platform and is rotated 360 degrees at each X-Y coordinate within the scan zone. Item images are captured by cameras at each X-Y coordinate and for each rotation at the corresponding X-Y coordinate. The item images are labeled and retained. The item images are used as input to a Machine-Learning Model (MLM) to train the MLM to recognize item codes for the items when subsequent images are captured for the item during a checkout. In an embodiment, during a checkout unknown item images are flagged and labeled with the corresponding item code when the corresponding item's barcode is scanned during the checkout; the labeled item images are also retailed for training the MLM for item recognition.

Abstract: The present disclosure provides an apixaban film product for treatment and prevention of thrombosis and related disorders. Also provided is a method of making the film product. The film product comprises an anticoagulant and a hydrophilic cellulosic polymer.

Abstract: Features are described for controlling the functionality of an electronic device, where the device operates according to a restricted mode of operation in which functions that the electronic device is otherwise capable of performing are not immediately available.

Abstract: Systems and apparatuses include a load map interface system including one or more processing circuits comprising one or more memory devices coupled to one or more processors, the one or more memory devices configured to store instructions thereon that, when executed by the one or more processors, cause the one or more processors to: receive a load map from an external input; determine a work machine load based at least in part on a sensor array of a work machine; generate a modified load map based on the received load map and the work machine load, the modified load map including an acceptable zone defining an acceptable load threshold and a warning zone defining a warning zone threshold; determine a location of the work machine on the modified load map; and send a notification to a display indicating that the work machine is within the acceptable zone or the warning zone.

Abstract: An electronic device changes the current user interface of a respective type of user interface from a first user interface to a second user interface. An individual uses their personal device to set up and configure a device for another user.

Abstract: A fast acting orally disintegrating film (ODF) for treatment of various medical conditions including emesis that has a simple formulation, easy to manufacture and has similar pharmacokinetic profile to currently commercially available orally administered drug products is provided. The ODF comprises an active pharmaceutical ingredient such as ondansetron or a pharmaceutical acceptable salt thereof in an amount of 2 to 24 mg, at least one hydrophilic film forming polymer in an amount of at least 8% by weight of the film, wherein the at least one hydrophilic film forming polymer is characterized by having a molecular weight of 5000 to 50000 Da, and a water soluble excipient in an amount of 10 to 30% by weight of the film.

Abstract: An electronic device changes the current user interface of a respective type of user interface from a first user interface to a second user interface. An individual uses their personal device to set up and configure a device for another user.

Abstract: A pramipexole transdermal patch for treatment of neurological disorders including Parkinson's disease that may be administered on a daily basis. The pramipexole transdermal patch of the present invention preferably comprises a drug-containing layer that comprises pramipexole or a pharmaceutically acceptable salt thereof at 2% to about 15% by weight of the drug-containing layer and at least two acrylic polymers wherein each polymer may further comprise carboxyl and/or hydroxyl functional groups. The pramipexole transdermal patch of the present invention may further comprise two or more permeation enhancers with combined pramipexole solubility of great than 50 mg/mL.

Abstract: The present invention relates to transdermal drug delivery system of pharmaceutical compositions, which have a satisfactory in-vitro performance and good bioavailability. In particular, the transdermal pharmaceutical composition of clobazam in the present invention includes a micro-emulsion in liquid or semi solid form, in a dosage form adapted for transdermal delivery (e.g., transdermal patch) for treatment of certain types of epilepsy and anxiety for continues application.

Abstract: The present invention relates to transdermal drug delivery system of pharmaceutical compositions, which have a satisfactory in-vitro performance and good bioavailability. In particular, the transdermal pharmaceutical composition of clobazam in the present invention includes a micro-emulsion in liquid or semi solid form, in a dosage form adapted for transdermal delivery (e.g., transdermal patch) for treatment of certain types of epilepsy and anxiety for continues application.

Abstract: An electronic device changes the current user interface of a respective type of user interface from a first user interface to a second user interface. An individual uses their personal device to set up and configure a device for another user.