Patents by Inventor Catherine Leimkuhler GRIMES

Catherine Leimkuhler GRIMES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic N-acetyl-muramic acid derivatives and uses thereof
    Patent number: 10988508
    Abstract: The present invention provides N-acetyl-muramic acid (NAM) derivatives having Formula I, wherein Xa is selected from the group consisting of X1-X59, Ya is selected from the group consisting of H, monophosphate, uridine diphosphate and ethyl azide linker prepared from 2-azido-ethanol, and Za is selected from the group consisting of OH, an ethylene diamine coupled fluorophore, a peptide and a peptide with an ethylene diamine coupled fluorophore, wherein the peptide is selected from the group consisting of a monopeptide, a dipeptide, a tripeptide and a pentapeptide. Also provided are methods for synthesizing NAM derivatives and methods for modulating Nod2 in cells, modifying bacterial cell wall or modulating innate immune response by a subject to bacterial cells upon exposure to NAM derivatives.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 27, 2021
    Assignee: University of Delaware
    Inventors: Catherine Leimkuhler Grimes, James E. Melnyk, Kristen E. Demeester, Hai Liang
  • SYNTHETIC N-ACETYL-MURAMIC ACID DERIVATIVES AND USES THEREOF
    Publication number: 20180298061
    Abstract: The present invention provides N-acetyl-muramic acid (NAM) derivatives having Formula I, wherein Xa is selected from the group consisting of X1-X59, Ya is selected from the group consisting of H, monophosphate, uridine diphosphate and ethyl azide linker prepared from 2-azido-ethanol, and Za is selected from the group consisting of OH, an ethylene diamine coupled fluorophore, a peptide and a peptide with an ethylene diamine coupled fluorophore, wherein the peptide is selected from the group consisting of a monopeptide, a dipeptide, a tripeptide and a pentapeptide. Also provided are methods for synthesizing NAM derivatives and methods for modulating Nod2 in cells, modifying bacterial cell wall or modulating innate immune response by a subject to bacterial cells upon exposure to NAM derivatives.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 18, 2018
    Applicant: University of Delaware
    Inventors: Catherine Leimkuhler GRIMES, James E. MELNYK, Kristen E. DEMEESTER, Hai LIANG