Abstract: The present invention relates to methods, uses, and compositions for the treatment of cancer (e.g., a lung cancer; a cervical cancer; a breast cancer; a head and neck cancer; a liver cancer; a bladder cancer; a gastric cancer; an esophageal cancer; a pancreatic cancer; a kidney or renal cancer; a melanoma; an ovarian cancer; or a colorectal cancer). More specifically, the invention concerns the treatment of patients having cancer with an anti-TIGIT antagonist antibody, including treatment with an anti-TIGIT antagonist antibody in a combination therapy.

Abstract: Described are systems and methods for determining a reputation score and/or a confidence score for a network identifier that represents, respectively, a likelihood that the network identifier presents a threat and/or a likelihood that the network activity associated with the network identifier corresponds to a port scanning, enumeration, or other malicious event. Embodiments of the present disclosure can utilize various network telemetry information, such as authentication activity, outbound traffic activity, web activity, honeypot connection activity, or network classification information to determine the reputation and/or confidence scores in response to a query/request and/or in connection with potentially malicious activity that can represent a likelihood that the detected potentially malicious activity is malicious/legitimate and the potential impact that remediation measures taken against the network identifier may have in the event that the detected network activity was legitimate.

Abstract: An in vitro microfluidic “organ-on-chip” device is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a stem cell-based Lung-on-Chip is described. This in vitro microfluidic system can be used for modeling differentiation of cells on-chip into lung cells, e.g., a lung (Lung-On-Chip), bronchial (Airway-On-Chip; small-Airway-On-Chip), alveolar sac (Alveolar-On-Chip), etc., for use in modeling disease states of derived tissue, i.e. as healthy, pre-disease and diseased tissues. Additionally, stem cells under differentiation protocols for deriving (producing) differentiated lung cells off-chips may be seeded onto microfluidic devices at any desired point during the in vitro differentiation pathway for further differentiation on-chip or placed on-chip before, during or after terminal differentiation.

Abstract: A method and apparatus for performing an action while a portable computing device is in a locked state is disclosed. An unlock image is displayed in a first region of a touch-sensitive display. Responsive to detecting contact with the touch-sensitive display at the first region, an action image is displayed in a second region of the touch-sensitive display. While the unlock image remains stationary at the first region, movement of the contact with the touch-sensitive display is detected and a direction of movement of the contact is determined. Responsive to determining the direction of movement of the contact is towards the action image, the action image is visually modified to distinguish it from the unlock image. Responsive to the contact with the touch-sensitive display reaching the second region, an action associated with the action image is performed.

Abstract: A method and apparatus for performing an action while a portable computing device is in a locked state is disclosed. An unlock image is displayed in a first region of a touch-sensitive display. Responsive to detecting contact with the touch-sensitive display at the first region, an action image is displayed in a second region of the touch-sensitive display. While the unlock image remains stationary at the first region, movement of the contact with the touch-sensitive display is detected and a direction of movement of the contact is determined. Responsive to determining the direction of movement of the contact is towards the action image, the action image is visually modified to distinguish it from the unlock image. Responsive to the contact with the touch-sensitive display reaching the second region, an action associated with the action image is performed.

Abstract: A method and apparatus for performing an action while a portable computing device is in a locked state is disclosed. An unlock image is displayed in a first region of a touch-sensitive display. Responsive to detecting contact with the touch-sensitive display at the first region, an action image is displayed in a second region of the touch-sensitive display. While the unlock image remains stationary at the first region, movement of the contact with the touch-sensitive display is detected and a direction of movement of the contact is determined. Responsive to determining the direction of movement of the contact is towards the action image, the action image is visually modified to distinguish it from the unlock image. Responsive to the contact with the touch-sensitive display reaching the second region, an action associated with the action image is performed.

Abstract: A method for predicting the sensitivity of tumor cells to an anthracycline-based chemotherapy includes determining the differential expression level of a MYBL2 gene in tumors cells. A polynucleotide library is useful to predict the sensitivity of tumor cells to an anthracycline-based chemotherapy and includes a pool of polynucleotide sequences or subsequences thereof wherein the sequences or subsequences correspond substantially to any of the polynucleotide sequences SEQ ID No: 308, SEQ ID No: 309 and/or SEQ ID No: 310 or the complements thereof.

Abstract: Method for molecular characterization of a carcinoma including: (i) detecting in tumor cells corresponding to breast tumor cells at least one polynucleotide selected from a first group determining expression level of the polynucleotide from the first group to differentiate a tumor in which a lymph node has been invaded by a tumor cell from a tumor in which a lymph node has not been invaded by a tumor cell; (ii) detecting in tumor cells corresponding to breast tumor cells at least one polynucleotide selected from a second group determining expression level of the polynucleotide from the second group to distinguish tumors sensitive to anthracycline from tumors insensitive to anthracycline; (iii) detecting in tumor cells corresponding to breast tumor cells at least one polynucleotide selected from a third group determining expression levels of the polynucleotide from the third group to classify good and poor prognosis primary breast tumors.

Abstract: A piston assembly (10) for a flowable materials container having a barrel (14) defining a fluid containing chamber (16). The barrel (14) is made of a body of a cyclic olefin containing polymer or a bridged polycyclic olefin containing polymer. An elastomeric piston (24) is slidably attached to the barrel (14) and provides a seal of the chamber. The piston (24) has a parylene coating on an outer surface thereof to reduce the necessary break away force. A plunger (22) is also provided and has a second mating member (42) removably connecting the plunger to a first mating member (44) of the piston. The first mating member (44) has a series of threads having a major diameter and a minor diameter, and the second mating member (42) has a series of threads having a major diameter and a minor diameter. The major and minor diameters of the second mating members (42) is appreciably smaller than the major and minor diameters of the other of the first mating member (44) to provide ease of connection.

Abstract: A polynucleotide library useful in the molecular characterization of a carcinoma, the library including a pool of polynucleotide sequences or subsequences thereof wherein the sequences or subsequences are overexpressed in tumor cells, further wherein the sequences or subsequences correspond substantially to any of the polynucleotide sequences set forth in any of SEQ ID NOS: 1-468 or the complement thereof.

Abstract: A compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and A are as defined in the description.

Abstract: By handling initial processing of HDLC frames, an HDLC engine can free up a server microprocessor that would otherwise be tasked to respond to incoming frames. Sharing a memory with the microprocessor, the engine periodically accesses an address status table in the memory to retrieve data in order to process received frames based on the status of the frame address.