Abstract: A method includes forming a mixture including a therapeutic agent and a solid delivery medium, injecting the mixture into a reservoir within an orthopedic implant body, and storing the injected mixture in the reservoir.

Abstract: An orthopedic implant device includes an implant body with a reservoir configured store a therapeutic agent. A wall of the implant body has opposite side surfaces, including a side surface facing into the reservoir. Elution channels reach from the reservoir through the body wall. The elution channels include an elongated channel traversing a thickness of the body wall between the opposite side surfaces. The elongated channel may have a length greater than twice the thickness.

Abstract: A method includes forming a mixture including a therapeutic agent and a solid delivery medium, injecting the mixture into a reservoir within an orthopedic implant body, and storing the injected mixture in the reservoir.

Abstract: An orthopedic implant device has a bone-replacement contour that replicates a healthy bone surface contour. An exterior surface of the device has elution pores. Interior surfaces of the device define a reservoir that is spaced inward from the exterior surface. The reservoir stores a therapeutic agent delivery medium impregnated with a therapeutic agent. The interior surfaces further define elution channels communicating the reservoir with the elution pores to convey a therapeutic agent from the reservoir to the exterior surface. A solid therapeutic agent delivery medium is stored in the reservoir, and is biodegradable under the influence of synovial fluid.