Patents by Inventor Catherine R. Gutman

Catherine R. Gutman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Complexes of apolipoprotein E and ciliary neurotrophic factor (CNTF) and methods of use
    Patent number: 6313089
    Abstract: Provided herein are compositions comprising complexes of apolipoprotein E and ciliary neurotrophic factor. The apolipoprotein E can be any isoform, but is preferably apolipoprotein E3. Also preferred are covalent complexes of apolipoprotein E and ciliary neurotrophic factor, more preferably those formed by intermolecular disulfide bonds between cysteine residues. Further provided are methods of enhancing the survival of neural cells by administering a composition comprising a complex of apolipoprotein E and ciliary neurotrophic factor. The claimed methods can be carried out both in vitro and in vivo.
    Type: Grant
    Filed: August 18, 1998
    Date of Patent: November 6, 2001
    Assignee: Duke University
    Inventors: William D. Matthew, Warren J. Strittmatter, Catherine R. Gutman
  • Source of apolipoprotein E and method of isolating apolipoprotein E
    Patent number: 5672685
    Abstract: Peritoneal fluid and peritoneal wash fluid provide a source of abundant apolipoprotein E. Methods for isolating apolipoprotein E from peritoneal fluid or peritoneal wash fluid are provided.
    Type: Grant
    Filed: October 4, 1995
    Date of Patent: September 30, 1997
    Assignee: Duke University
    Inventors: William D. Matthew, Warren J. Strittmatter, Catherine R. Gutman