Abstract: Provided herein are RNAi molecules including a first strand containing a guide sequence and a second strand comprising a non-guide sequence where the non-guide sequence contains a bulge opposite the seed region of the guide sequences; e.g., opposite the cleavage sequence. In some aspects, the invention provides RNAi for treating Huntington's disease. Further provided herein are expression cassettes, vectors (e.g., rAAV, recombinant adenoviral, recombinant lentiviral, and recombinant HSV vectors), cells, viral particles, and pharmaceutical compositions containing the RNAi. Yet further provided herein are methods and kits related to the use of the RNAi, for example, to treat Huntington's disease.

Abstract: Disclosed is a cosmetic make-up or keratin material care composition including at least one silicone-polyurethane polymer and a silicone resin in a physiologically acceptable medium. Also disclosed is a make-up or keratin substance care method involving applying the composition to the keratin material, and the use of an MQ-functional trimethylsiloxy silicate silicone polymer for improving the resistance to rubbing-off and the fastness of a cosmetic composition including at least one silicone-polyurethane polymer in an physiologically acceptable medium.

Abstract: An apparatus is presented which, carried by or embedded in a lonely or socially inept individual, communicates with like devices in such a way as to divine the likelihood of attraction due to relative sexual, social, intellectual or spiritual interests of the bearers. It may either be programmed explicitly by a trusted body, or suspect compatibility by observing and mining patterns of behaviour, environment and physiological response in the users of the said devices. The users are signalled or led to initial interaction in such a way as to maximize the likelihood of prolonged and deepened contact.