Patents by Inventor Catherine S. Coleman

Catherine S. Coleman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions relating to E3 ring-E2 fusion proteins
    Patent number: 8273540
    Abstract: Compositions are provided according to embodiments of the present invention which include an isolated fusion protein including an E3 protein RING motif bonded to an UCE E2 protein. In preferred embodiments, the C-terminus of the E3 protein RING motif is bonded to the N-terminus of the UCE E2 protein by an intervening peptide linker. Optionally, the peptide linker is 5-50 amino acids. Preferred is a peptide linker of 15-20 amino acids. Methods of identifying ubiquitylation modulators are provided according to embodiments of the present invention which include contacting an isolated fusion protein including an E3 protein RING motif bonded to an UCE E2 protein with a ubiquitylation substrate in the presence of a test substance. Ubiquitylation of the ubiquitylation substrate is then detected to determine the effect of the test substance on ubiquitylation of the ubiquitylation substrate.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: September 25, 2012
    Assignee: The Penn State Research Foundation
    Inventors: Vincent Chau, Catherine S. Coleman, Kristine C. Olson
  • METHODS AND COMPOSITIONS RELATING TO E3 RING-E2 FUSION PROTEINS
    Publication number: 20100092998
    Abstract: Compositions are provided according to embodiments of the present invention which include an isolated fusion protein including an E3 protein RING motif bonded to an UCE E2 protein. In preferred embodiments, the C-terminus of the E3 protein RING motif is bonded to the N-terminus of the UCE E2 protein by an intervening peptide linker. Optionally, the peptide linker is 5-50 amino acids. Preferred is a peptide linker of 15-20 amino acids. Methods of identifying ubiquitylation modulators are provided according to embodiments of the present invention which include contacting an isolated fusion protein including an E3 protein RING motif bonded to an UCE E2 protein with a ubiquitylation substrate in the presence of a test substance. Ubiquitylation of the ubiquitylation substrate is then detected to determine the effect of the test substance on ubiquitylation of the ubiquitylation substrate.
    Type: Application
    Filed: October 9, 2009
    Publication date: April 15, 2010
    Applicant: The Penn State Research Foundation
    Inventors: Vincent Chau, Catherine S. Coleman, Kristine C. Olson