Abstract: Oxidized metal complexes are formed using methods which adjust the pH of solutions to obtain oxidized metal complexes having particular physicochemical properties. A method for preparing an oxidized metal complex includes providing a first solution comprising a highly oxidized metal and having a pH between 0 to 7; providing a second solution comprising one or more ligands or a ligand precursor and having a pH between 7 to 13 or greater; and combining the first solution and the second solution to form a third solution comprising the first oxidized metal complex. A method for preparing an oxidized metal complex includes providing a species solution comprising a first oxidized metal complex and having a pH of at least pH 11; and adjusting the pH of the species solution to form a second oxidized metal complex. Compositions and methods for preparing and using same are provided.

Abstract: Compositions include a hydrophobic continuous phase having a powdery oxidizing agent (e.g. silver oxynitrate) and a disperse hydrophilic phase comprising at least one hydrophilic substance (e.g. fumed silica) that maintain antimicrobial/anti-biofilm activities; and methods for preparing and using same.

Abstract: Methods for the production of co-deposition products include an oxidized metal species attached to silica in the presence of oxidation means. Also provided are methods for the production of composite materials which include a substrate and the co-deposition product. Furthermore, methods for producing a multi-layered co-deposition product which include two or more layers of the co-deposition product are also described. Co-deposition products comprising an oxidized species of metal, such as oxidized silver or copper, attached to silica are also provided. In a preferred embodiment, the metal is silver, and the resulting co-deposition product provides anti-microbial, anti-fungal and/or anti-biofilm properties to materials.

Abstract: The technology described herein is directed to methods and devices that can be used to induce functional organ structures to form within an implantation device by implanting it in vivo within the body of a living animal, and allowing cells and tissues to impregnate the implantation device and establish normal microenvironmental architecture and tissue-tissue interfaces. Then the contained cells and tissues can be surgically removed intact and either transplanted into another animal or maintained ex vivo by perfusing it through one or more of the fluid channels with medium and/or gases necessary for cell survival.

Abstract: The technology described herein is directed to methods and devices that can be used to induce functional organ structures to form within an implantation device by implanting it in vivo within the body of a living animal, and allowing cells and tissues to impregnate the implantation device and establish normal microenvironmental architecture and tissue-tissue interfaces. Then the contained cells and tissues can be surgically removed intact and either transplanted into another animal or maintained ex vivo by perfusing it through one or more of the fluid channels with medium and/or gases necessary for cell survival.

Abstract: Provided herein are compositions and methods comprising ROS target modulators that increase ROS flux and endogenus ROS production, thereby potentiating oxidative attack by antibiotics and biocides.

Abstract: The technology described herein is directed to methods and devices that can be used to induce functional organ structures to form within an implantation device by implanting it in vivo within the body of a living animal, and allowing cells and tissues to impregnate the implantation device and establish normal microenvironmental architecture and tissue-tissue interfaces. Then the contained cells and tissues can be surgically removed intact and either transplanted into another animal or maintained ex vivo by perfusing it through one or more of the fluid channels with medium and/or gases necessary for cell survival.