Patents by Inventor Catherine TEMPEL-BRAMI

Catherine TEMPEL-BRAMI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TTField treatment with optimization of electrode positions based on low frequency (<1MHZ) AC conductivity estimates derived from two MRI images having different repetition times
    Patent number: 11650277
    Abstract: A 3D model of AC electrical conductivity (at a given frequency) of an anatomic volume can be created by obtaining two MRI images of the anatomic volume, where the two images have different repetition times. Then, for each voxel in the anatomic volume, a ratio IR of the intensity of the corresponding voxels in the two MRI images is calculated. This calculated IR is then mapped into a corresponding voxel of a 3D model of AC electrical conductivity at the given frequency. The given frequency is below 1 MHz (e.g., 200 kHz). In some embodiments, the 3D model of AC electrical conductivity at the given frequency is used to determine the positions for the electrodes in TTFields (Tumor Treating Fields) treatment.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: May 16, 2023
    Assignee: Novocure GmbH
    Inventors: Cornelia Wenger, Catherine Tempel-Brami, Hadas Sara Hershkovich, Moshe Giladi, Zeev Bomzon
  • TTField Treatment with Optimization of Electrode Positions Based on Low Frequency (<1MHZ) AC Conductivity Estimates Derived From Two MRI Images Having Different Repetition Times
    Publication number: 20190308016
    Abstract: A 3D model of AC electrical conductivity (at a given frequency) of an anatomic volume can be created by obtaining two MRI images of the anatomic volume, where the two images have different repetition times. Then, for each voxel in the anatomic volume, a ratio IR of the intensity of the corresponding voxels in the two MRI images is calculated. This calculated IR is then mapped into a corresponding voxel of a 3D model of AC electrical conductivity at the given frequency. The given frequency is below 1 MHz (e.g., 200 kHz). In some embodiments, the 3D model of AC electrical conductivity at the given frequency is used to determine the positions for the electrodes in TTFields (Tumor Treating Fields) treatment.
    Type: Application
    Filed: April 9, 2019
    Publication date: October 10, 2019
    Applicant: Novocure Limited
    Inventors: Cornelia WENGER, Catherine TEMPEL-BRAMI, Hadas Sara HERSHKOVICH, Moshe GILADI, Zeev BOMZON