Abstract: An apparatus and method for pumping and optionally mixing of small quantities of biological fluid wherein the pumping mechanism is segregated from the biological fluid being pumped. The micro-pump pushes the biological fluid by compressing a cartridge housing the blood and reagents with collapsible walls with a roller or ball bearing, synchronized perpendicular plungers, or an acutely-angled member to push the biological fluid by collapsing the walls of the cartridge in the direction of flow.

Abstract: A method is provided of depositing a plurality of droplets of a bioactive material at a first concentration in a fluid to form a spot on a substrate, the spot having a first bioactivity level; and controlling the plurality of droplets to control the size of the spot and control the bioactivity level of the spot to not be equal to the number of droplets times the first bioactivity level.

Abstract: A system and method for measuring flow rate within a fluid-bearing passageway include introducing heat fluctuations into the flow and then non-invasively monitoring the effects of the heat fluctuations propagating to or from one or more interrogation regions. In one embodiment, the non-invasive monitoring detects fluctuations in the refractive index of the flowing fluid as a result of variations in the temperature of the fluid. In another embodiment, electrical conductivity of the fluid is monitored. The heat fluctuations may be introduced using an optical heat generator, such as an infrared laser, or may be introduced using an electrical member, such as a heater coil. Determining the refractive index along the interrogation region may be achieved by monitoring characteristics on an interference pattern, but other optical arrangements may be utilized.