Abstract: Systems and methods related to propulsion battery mount assemblies for micro-mobility transit vehicles are disclosed. For example, in an embodiment the battery mount assembly includes a mounting rail having a first side comprising a contoured surface configured to align with a complementary contoured surface of a frame of a micro-mobility transit vehicle and a second side comprising a battery mounting surface opposite the first side and configured to receive a first securing assembly and a second securing assembly entirely disposed thereon and separately spaced to receive a battery pack therebetween. The battery mount assembly may be installed on the frame of a micro-mobility transit vehicle to assist in expedient replacement of battery packs that electrically power the micro-mobility transit vehicle.

Abstract: Implementing extended reality (XR) tags in an XR platform is described. A server(s) may obtain, via a user interface of an application executing on a client device, a definition of an XR tag, and may embed information in the XR tag in accordance with the definition of the XR tag. The server(s) may further obtain, via the user interface, one or more rules applicable to the XR tag. The server(s) may further store data representing the XR tag in a data store. In some examples, the definition and/or the one or more rules allow for customizing the XR tag and/or the information embedded in the XR tag to other client devices that are accessing the XR tag, users of the other client devices, and/or a creator of the XR tag.

Abstract: A kiosk maintains a list of pre-paid orders. A first authentication process enables a consumer to select their order on the kiosk so as to receive the product or service that was remotely paid for via a mobile application. Authentication of the consumer selecting the order is performed based upon sending an order authentication notification to the mobile application that completed the order. If the user of the mobile application provides a positive authentication reply, the kiosk is unlocked to fulfill the order. The consumer may alternatively be authenticated by providing a personal identification number (PIN) that is associated with the order or associated with a user of the mobile application. Authentication using the PIN enables a consumer to interact with the kiosk to receive the previously ordered product or service without having to access their mobile phone or mobile application that was used to place the order.

Abstract: A semiconductor device has a semiconductor die including a photonic circuit. A first adhesive bead is deposited over the semiconductor die around the photonic circuit. A second adhesive bead is deposited over the first adhesive bead. An inner edge of the second adhesive bead is offset toward the photonic circuit relative to an inner edge of the first adhesive bead. A lens is disposed over the second adhesive bead. An encapsulant is deposited over the semiconductor die and lens.

Abstract: Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle). In other embodiments, the invention provides methods to determine the heterogeneity of AAV particles. In some aspects, the invention provides viral particles (e.g., rAAV particles) with improved stability and/or improved transduction efficiency by increasing the acetylation and/or deamidation of capsid proteins.

Abstract: Disclosed herein are antibodies and compositions used for binding to Gal3. Some embodiments allow for disrupting interactions between Galectin-3 (Gal3) and cell surface markers and/or proteins associated with neurological diseases and/or proteopathies, such as Alzheimer's disease. Additionally, disclosed herein are methods of treatment and uses of the antibodies or binding fragments thereof for the treatment of fibrosis, liver fibrosis, kidney fibrosis, cardiac fibrosis, pulmonary fibrosis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, sepsis, atopic dermatitis, psoriasis, cancer, brain cancer, breast cancer, colorectal cancer, kidney cancer, liver cancer, lung cancer, pancreatic cancer, bladder cancer, stomach cancer, hematological malignancy, neurological diseases and/or proteopathies. Furthermore, some embodiments provided herein can cross the blood-brain barrier and can be conjugated or otherwise associated with one or more payloads for the treatment of a neurological disease.

Abstract: A semiconductor device has a photonic semiconductor die and a lens mounted onto the photonic semiconductor die. The photonic semiconductor die and lens are singulated prior to mounting the lens onto the photonic semiconductor die. An adhesive bead is formed on the photonic semiconductor die to seal a cavity between the lens and photonic semiconductor die. The photonic semiconductor die and lens are disposed into a storage media for transporting the photonic semiconductor die to a semiconductor packaging facility. The photonic semiconductor and lens are disposed on a substrate after mounting the lens onto the photonic semiconductor die. An encapsulant is deposited over the substrate, lens, and photonic semiconductor die.

Abstract: Peroxyformic acid compositions for removal of biofilm growth and other contaminants and impurities from industrial processing hard surfaces are disclosed. In particular, peroxyformic acid compositions may be dosed on site and/or generated in situ for the reduction and prevention of biofilms on the hard surfaces. Methods of employing the peroxyformic acid compositions for removal of biofilm growth and other impurities such as aldehydes and alcohols from industrial CO2 effluent are also disclosed which beneficially provide ambient biofilm control and break down more rapidly than other peracids, allowing for extended runs between CIP cleaning, including a reduction and/or elimination of cleaning of the scrubbers and other industrial surfaces.

Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to contain and dispense a fluid, such as a thixotropic fluid. In some embodiments, a bottle having a closure cap includes a control device, a base, and a disk, where the base and disk define a mixing chamber configured to facilitate mixing of any serum or liquid separated from the fluid back therein. In some embodiments, a dispensing bottle includes a non-removable closure cap with a tamper evident feature that indicates whether the cap was previously opened. By one approach, the dispensing bottle includes discontinuous threads on a bottle neck and ratchet projections on a closure cap that engage the discontinuous thread(s) to prevent or inhibit manual removal of the cap from the bottle.

Abstract: A portable power supply including an internal power source, an AC output, a DC output, and an input unit configured to receive power from a first external source. The portable power supply further includes a first power conversion unit configured to convert the power received from the first external source to a first DC power used for charging the internal power source, an AC power conversion unit configured to convert power output by the internal power source to an AC power used for powering a first peripheral device connected to the AC output, and a DC power conversion unit configured to convert power output by the internal power source to a second DC power used for powering a second peripheral device connected to the DC output.

Abstract: The present disclosure is directed to methods and/or uses of oligonucleotide conjugates for assays and flow cytometry detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein.

Abstract: A level shifter includes a first input having low voltage switches, and is configured to receive an input voltage and to generate a second voltage which varies between a first low voltage and a first high voltage. The level shifter also includes a first output having medium voltage switches, and is configured to receive the second voltage and to generate a third voltage which varies between the first low voltage and a second high voltage. The level shifter also includes a second input having medium voltage switches, and is configured to receive the third voltage and to generate a fourth voltage which varies between a second low voltage and the second high voltage. The level shifter also includes a second output having medium voltage switches, and is configured to receive the fourth voltage and generate a fifth voltage which varies between the second low voltage and a third high voltage.

Abstract: Cancer is the second leading cause of death in the United States. Increasingly, immune modulating therapies, such as therapy with immune checkpoint inhibitors (ICI) are being explored as promising potential therapies for many cancers. Presented herein are systems and methods for prediction, and especially automated prediction, of subject response to cancer therapies. Also presented herein are methods for selection of cancer therapies based upon predicted subject response and/or technologies for administering cancer therapies to appropriate subjects.

Abstract: A method of demethylizing an opioid to a nor-opioid is provided. The method comprises contacting an opioid with at least one enzyme. Contacting the opioid with the at least one enzyme converts the opioid to a nor-opioid. A method of converting a nor-opioid to a nal-opioid is provided. The method comprises contacting a nor-opioid with at least one enzyme. Contacting the nor-opioid with the at least one enzyme converts the nor-opioid to a nal-opioid.

Abstract: Systems and methods are described herein for optimizing cloud architectures using artificial intelligence models trained on standardized cloud architecture patterns corresponding to specific requirements. For example, the system may receive a first cloud architecture processing requirement. The system may receive a first set of available cloud resources. The system may generate a first feature input based on the first cloud architecture processing requirement and the first set of available cloud resources. The system may input the first feature input into a first artificial intelligence model to generate a first output. The system may determine, based on the first output, a first cloud architecture pattern for the first set of available cloud resources.

Abstract: This invention provides stable aqueous formulations comprising a bG-CSF polypeptide or a variant thereof, a buffer substance, and an excipient, wherein said formulation is substantially free of polyoxyethylene (20) sorbitan monolaurate. The invention also provides methods of using, a lyophilized or powdered form of, and processes for, preparing the formulation.

Abstract: A server system is communicatively connected to a plurality of computing devices and one or more databases. The server system receives one or more queries from a computing device. The one or more queries specify a data source. The server system determines a level of security applicable to a user of the computing device. The server system translates the one or more queries into one or more logical queries according to semantics of the data source, and transmits the logical queries to a query pipeline of the server system. The server system executes the one or more queries against a first database of the one or more databases to retrieve query results from the data source. The server system applies the determined level of security to the query results to obtain one or more data sets, and returns the one or more data sets to the computing device.