Abstract: A mattress overlay apparatus is provided for use with a mattress. The mattress overlay apparatus includes an overlay configured for placement atop the mattress and having a plurality of inflatable bladders, a blower, and first and second rotary plate valves pneumatically coupled to the plurality of bladders and the blower. The first and second rotary plate valves are arranged in series between the plurality of bladders and the blower. The first and second rotary plate valves and the blower are operated to provide the overlay with percussion and vibration (P&V), left and right turn assist, and microclimate management (MCM) functionality.

Abstract: Initial and boundary conditions, and parameters associated with geophysical modeling can be received. Based on the received initial and boundary conditions and parameters, a multiscale model can be trained for data generation to produce first resolution simulation data and second resolution simulation data for a surrogate machine learning model training, where the second resolution simulation data has higher resolution than the first resolution simulation data. A surrogate model can be created using neural operators, where the surrogate model is trained using the first resolution simulation data and second resolution simulation data. An operational forecasting model can be generated using the surrogate model.

Abstract: A communication device for use in a care facility includes a housing configured to be worn on a caregiver, a display disposed on the housing, a microphone configured to detect sound signals, and a speaker configured to convert an electromagnetic wave input into a sound wave output. The communication device further includes a controller configured to control or receive input from the display, the microphone, and the speaker.

Abstract: The present invention relates to the treatment of subjects having relapsed and/or refractory (R/R) follicular lymphoma (FL). More specifically, the invention pertains to the treatment of subjects having R/R FL by administering a combination of mosunetuzumab and lenalidomide.

Abstract: The invention pertains to a method for treating a cancer which expresses PRAME using T cells which recognize specific peptide epitopes of PRAME, to a method for producing T cells that target cancer cells expressing PRAME, the peptide epitopes of PRAME themselves and to compositions and methods of treatment using these peptides.

Abstract: The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A makeup removal composition includes at least one silicone crosspolymer-based emulsifier, at least one polyglyceryl ester with HLB less than 10, at least one branched or linear liquid alkane with carbon chain length of C11 to C20, at least one polar emollient ester with carbon chain length of C12 to C24, water, or water and a water-based hydrating agent or solvent or combination thereof, and, optionally one or more additives.

Abstract: The present invention relates to neoplasia vaccine or immunogenic composition administered in combination with other agents, such as checkpoint blockade inhibitors for the treatment or prevention of neoplasia in a subject.

Abstract: Anti-TIGIT antibodies and antigen binding fragments thereof that inhibit TIGIT-mediated signalling are provided, together with combinations comprising said antibodies or antigen binding fragments thereof and methods for their use.

Abstract: This application relates to systems and methods for auditing registers. In some examples, a system comprises registers, a recycling device, handheld computing devices, and retailer computing devices. The retailer computing devices may be configured to store a decision model, receive a calculated monetary position and activity data for one of the registers, generate a first associate record based at least on the decision model and one or more of the calculated monetary position and the activity data, generate a second associate record based at least on the decision model and historical behavioral data for one or more associates, generate a first audit alert record based at least on the second associate record and the decision model, send audit alerts to the handheld computing devices, and send the first audit alert record to the database.

Abstract: A method of diagnosing and treating a cardiovascular disease in a patient, the method comprising the steps of: determining whether the patient has an increase in stem cell memory T (Tscm) cells by: obtaining or having obtained a biological sample from the patient; performing or having performed an assay on the biological sample to determine the amount of Tscm in the patient, wherein the T scm are at least one of: CD8+CD45RA+CCR7+CD27+CD28+CD95+ T cells, CD4+CD45RA+CCR7+CD27+CD28+CD95+ T cells, or CD8+CD3+CD45RA+CCR7+C D45RO? CD95+ T cells; identifying that the patient has an increase in Tscm when compared to the amount of Tscm in a healthy patient; and if the patient has an increase in Tscm, then administering therapy for the treatment of the cardiovascular disease to the patient.

Abstract: Systems and methods are provided for employing analog content addressable memory (aCAMs) to achieve low latency complex distribution sampling. For example, an aCAM core circuit can include an aCAM array. Amplitudes of a probability distribution function are mapped to a width of one or more aCAM cells in each row of the aCAM array. The aCAM core circuit can also include a resistive random access memory (RRAM) storing lookup information, such as information used for processing a model. By randomly selecting columns to search of the aCAM array, the mapped probability distribution function is sampled in a manner that has low latency. The aCAM core circuit can accelerate the sampling step in methods relying on sampling from arbitrary probability distributions, such as particle filter techniques. A hardware architecture for an aCAM Particle Filter that utilizes the aCAM core circuit as a central structure is also described.

Abstract: An anonymous, decentralized, high speed, open source, data-only, wireless network is deployed in physical space. A server attached to the network generates a Non-Fungible Token (NFT) and associates the NFT with a first network device (e.g., a cellular antennae) before the first network device is deployed in the cellular network. After deployment of the first network device into the cellular network, a second network device (e.g., a network validator) can identify the first network device with information from the NFT. In this way, a digital token can identify a physical piece of hardware for communications within the cellular network.

Abstract: The present invention relates to enhancing mechanical properties of tissue such as collagenous or collagen-containing or elastin-containing tissue (e.g., tendons, ligaments, and cartilage) and treating related musculoskeletal and non-musculoskeletal conditions or injuries.

Abstract: A composition is provided. The composition is a water-in-oil emulsion comprising an aqueous phase and an oil phase. The aqueous phase comprises water, one or more humectants, one or more preservatives, one or more preservative boosters, one or more stabilizers and/or one or more pH adjusters. The oil phase comprises one or more solvents, one or more emulsifiers, one or more emollients and/or one or more aesthetic modifiers. Methods of preparing the composition and methods of improving the appearance of skin are also provided.

Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.