Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of penicillin-binding proteins (PBPs) more particularly PBP3. The invention also includes pharmaceutical compositions comprising said peptide ligands and to the use of said peptide ligands in suppressing or treating a disease or disorder mediated by bacterial infection or for providing prophylaxis to a subject at risk of infection.

Abstract: A method of demethylizing an opioid to a nor-opioid is provided. The method comprises contacting an opioid with at least one enzyme. Contacting the opioid with the at least one enzyme converts the opioid to a nor-opioid. A method of converting a nor-opioid to a nal-opioid is provided. The method comprises contacting a nor-opioid with at least one enzyme. Contacting the nor-opioid with the at least one enzyme converts the nor-opioid to a nal-opioid.

Abstract: A magnetorheological (MR) actuator device comprising two or more MR actuator units. Each of the MR actuator units may include a motor, an MR fluid clutch apparatus operatively coupled to the motor to receive torque from the motor, the MR fluid clutch apparatus operable to generate a variable amount of torque transmission when subjected to a magnetic field. An output member is provided, a transmission operatively coupling the at least two MR actuator units to the output member, for the output member to receive torque from the MR actuator units. A controller for controlling the two or more MR actuator units to drive the output member, the controller driving the output member in at least an antagonistic mode in which the MR actuator units transmit torque in opposite directions to the output member. A collaborative mode may be provided to combined the torque of the two or more MR actuator units in a common direction on the output member.

Abstract: Disclosed is a composition including, per 100% of its mass: a) 60.0% to 75.0% by mass of an organic solvent (OS1) chosen from 1,2-propanediol, 1,3-propanediol, 1,4-butanediol, 1,3-butanediol, 1,2-butanediol, 2-methyl-2,4-pentanediol, 1,6-hexanediol, 1,8-octanediol, or a mixture of these compounds; b) 0.1% to 2.0% by mass of a composition (ES) including an amount by mass x1, expressed as mass equivalent of 1-O-(2-caffeoyl)maloyl-3,5-di-O-catfeoylquinic acid, of greater than or equal to 200 mg/g of a compound of general formula (I): in which Q1, Q2, Q3, Q4 and Q5 represent, independently of each other, a hydroxyl radical or a salt thereof or a radical chosen from caffeoyl, maloyl, caffeoyl maloyl and maloyl caffeoyl radicals, it being understood that at least one of these radicals Q1, Q2, Q3, Q4 and Q5 represents neither the —OH radical nor a salt thereof; and c) 20.0% to 35.0% by mass of water. Related treatments are also disclosed.

Abstract: Disclosed herein are methods and compositions for disrupting an interaction between Galectin-3 and insulin receptor or integrins. Further disclosed herein are methods and compositions for the treatment of a disease or a disorder in a subject, such as the treatment of diabetes mellitus, inflammatory bowel syndrome, non-alcoholic fatty liver disease, and nonalcoholic steatohepatitis.

Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.

Abstract: A patient support apparatus includes a support surface including a topper. An opening is formed in a side of the support surface. A cavity extends from the opening into the support surface. An inlet port is positioned within the cavity and fluidly coupled to the topper. A pneumatic blower is configured to removably position within the cavity and has an outlet port that couples to the inlet port.

Abstract: A method of testing non-volatile memory cells formed on a die includes erasing the memory cells and performing a first read operation to determine a lowest read current RC1 for the memory cells and a first number N1 of the memory cells having the lowest read current RC1. A second read operation is performed to determine a second number N2 of the memory cells having a read current not exceeding a target read current RC2. The target read current RC2 is equal to the lowest read current RC1 plus a predetermined current value. The die is determined to be acceptable if the second number N2 is determined to exceed the first number N1 plus a predetermined number. The die is determined to be defective if the second number N2 is determined not to exceed the first number N1 plus the predetermined number.

Abstract: An oil level measuring device has a distal end and a proximal end. The oil level measuring device includes an arm comprising a first channel and a second channel, an electronic oil level sensor comprising a measuring mean configured to measure the level of the oil in an oil pan and a connecting port, the measuring mean being hosted into the first channel of the arm, a dipstick hosted into the second channel of the arm and configured to dip into the oil in the oil pan.

Abstract: Polyethers are prepared by polymerizing an alkylene oxide in the presence of a starter, an aluminum compound that has at least one hydrocarbyl substituent, and a cyclic amidine. The phosphorus-nitrogen base is present in only a small molar ratio relative to the amount of starter. The presence of such small amounts of cyclic amidine greatly increases the catalytic activity of the system, compared to the case in which the aluminum compound is used by itself. The product polyethers have low amounts of unsaturated polyether impurities and little or no unwanted high molecular weight fraction. Polymers of propylene oxide have very low proportions of primary hydroxyl groups.

Abstract: Security policies may be utilized to grant or deny permissions related to the access of computing resources. Two or more security policies may be compared to determine whether the policies are equivalent, whether one security is more permissive than another, and more. In some cases, it may be possible to identify whether there exists a security permission that is sufficient to determine two security policies lack equivalency. Propositional logics may be utilized in the evaluation of security policies.

Abstract: A virtual adhesion method is provided. The virtual adhesion method includes increasing a magnetic characteristic of an initial structure, supporting the initial structure on a surface of a substrate, generating a magnetic field directed such that the initial structure is forced toward the surface of the substrate and forming an encapsulation, which is bound to exposed portions of the surface, around the initial structure.

Abstract: Examples described herein relate to a decision tree computation system in which a hardware accelerator for a decision tree is implemented in the form of an analog Content Addressable Memory (a-CAM) array. The hardware accelerator accesses a decision tree. The decision tree comprises of multiple paths and each path of the multiple paths includes a set of nodes. Each node of the decision tree is associated with a feature variable of multiple feature variables of the decision tree. The hardware accelerator combines multiple nodes among the set of nodes with a same feature variable into a combined single node. Wildcard values are replaced for feature variables not being evaluated in each path. Each combined single node associated with each feature variable is mapped to a corresponding column in the a-CAM array and the multiple paths of the decision tree to rows of the a-CAM array.

Abstract: Provided herein are trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation, and wherein and a second pair of polypeptides possess a single variable domain forming a single antigen binding site. In some embodiments, the binding proteins comprise a binding site that binds a CD28 polypeptide, a binding site that binds a CD3 polypeptide, and a binding site that binds a third polypeptide, such as a tumor target protein. In some embodiments, the binding proteins comprise four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins. The disclosure also relates to methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: A quantum circuit called a “qumon” is provided to cancel unwanted ZZ interaction in a superconducting qubit architecture. The qumon qubit has a high coherence, and a positive anharmonicity that may be tuned to cancel the negative anharmonicity in a coupled qubit, such as a transmon qubit. The qumon has three parallel branches, in which are a shunt capacitor; a Josephson junction having weighted energy level and capacitance; and several Josephson junctions in series. The weight is chosen to provide the desired anharmonicity, and the transverse flux noise and transverse charge noise each decrease in proportion to the number of the Josephson junctions in series. Because unwanted ZZ interactions are canceled, qumon qubits and transmon qubits may be capacitively coupled in an alternating pattern to provide a surface code in which these interactions are canceled in an extensible way.

Abstract: A system may include a platform for an application to support processing flows for a service provider, such as ordering, sales, support, service delivery, and related process flows. The system may provide a limited set of application programming interfaces (APIs) that map to an application's user-experience page flows. The APIs may always appear to the application that the interaction process completed successfully—even if human intervention is required—to allow the application to complete the transaction. The system may have the ability to recognize the same user, and leverage that user's behavior across interactions with multiple sales channels. The system may thus provide, in one aspect, an enhanced user experience for ordering and maintaining complex service and equipment offerings.

Abstract: A folding trailer ramp suitable for heavy machinery has powered full extension and soft ground contact. A prime mover such as an air bag and actuator assembly rotates one link of a quadrilateral linkage. When deploying the folding ramp, the quadrilateral linkage fully extends a ramp tip from a main ramp segment before the ramp tip touches down onto the ground. The ramp tip locks into a stable position when fully extended. A push rod that forms a second link of the quadrilateral linkage is in some embodiments adjustable in length, and in further embodiments includes a spring pack that only changes length after the ramp tip is fully extended and locked into a stable position. A pivot arm that forms another link may terminate at an anti-friction roller that presses against and thereby locks the ramp tip. A roller channel may also partially encompass and protect the anti-friction roller.

Abstract: Polyethers are prepared by polymerizing an alkylene oxide in the presence of a starter, an aluminum compound that has at least one hydrocarbyl substituent, and a phosphorus-nitrogen base. The phosphorus-nitrogen base is present in only a small molar ratio relative to the amount of starter. The presence of such small amounts of phosphorus-nitrogen base greatly increases the catalytic activity of the system, compared to the case in which the aluminum compound is used by itself. The product polyethers have low amounts of unsaturated polyether impurities and little or no unwanted high molecular weight fraction. Polymers of propylene oxide have very low proportions of primary hydroxyl groups.

Abstract: Embodiments of the disclosure provide for a knowledge search engine platform to identifying first data associated with a merchant system from one or more databases based on a search query submitted by a user device. The knowledge search engine platform generates a user dialog interface to display to the user device to enable a communication to collect additional information to supplement the first data. Second data to supplement the first data is received from the user system via the user dialog interface. Responsive to receiving the second data, a set of communications are transmitted to a set of search provider systems, where each communication of the set of communications comprising a recommended update comprising the first data and the second data.

Abstract: The present disclosure is related to receiving a communication (e.g., direct message, group message, calendar event, task, etc.) on a first device and providing an option to request that a reminder, which is associated with the communication, be presented a second device. For example, the communication may be presented via a mobile client, and the user may request that a reminder be presented via a desktop client (e.g., when the user is at the desktop client).