Patents by Inventor Catherine Van Montfrans

Catherine Van Montfrans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-10 gene transfer to peripheral mononuclear cells
    Patent number: 8119401
    Abstract: The present invention to methods for producing mononuclear cells overexpressing IL-10. The method comprises the ex vivo introduction of an expression construct comprising a nucleotide sequence encoding a polypeptide having IL-10 activity into peripheral blood mononuclear cells of a subject. The thus obtained peripheral blood mononuclear cells have an altered phenotype as a result of the expression of an introduced IL-10 transgene. In particular the invention relates to CD4+ T cells that functionally behave as regulatory T cells as a result of the expression of an IL-10 transgene. The IL-10 transgenic mononuclear cells may be used to treat a variety of inflammatory diseases, particularly T helper 1-mediated inflammatory diseases.
    Type: Grant
    Filed: March 7, 2003
    Date of Patent: February 21, 2012
    Assignee: Amsterdam Molecular Therapeutics (AMT) IP B.V.
    Inventors: Sander Jan Hendrik Van Deventer, Catherine Van Montfrans
  • Il-10 gene transfer to peripheral mononuclear cells
    Publication number: 20070053889
    Abstract: The present invention to methods for producing mononuclear cells overexpressing IL-10. The method comprises the ex vivo introduction of an expression construct comprising a nucleotide sequence encoding a polypeptide having IL-10 activity into peripheral blood mononuclear cells of a subject. The thus obtained peripheral blood mononuclear cells have an altered phenotype as a result of the expression of an introduced IL-10 transgene. In particular the invention relates to CD4+ T cells that functionally behave as regulatory T cells as a result of the expression of an IL-10 transgene. The IL-10 transgenic mononuclear cells may be used to treat a variety of inflammatory diseases, particularly T helper 1-mediated inflammatory diseases.
    Type: Application
    Filed: March 7, 2003
    Publication date: March 8, 2007
    Inventors: Sander Van Deventer, Catherine Van Montfrans