Abstract: The present invention provides compositions and methods for treating peanut allergy. The compositions comprise chemically modified peanut allergen proteins selected from Ara h 1, h 2, h 3, h 6, h 8, and h 9, wherein the proteins are chemically crosslinked using a dialdehyde crosslinking agent and exhibit reduced IgE binding affinity. Methods of treatment comprise administering to a subject a composition containing at least one chemically crosslinked peanut allergen protein selected from Ara h 1, h 2, h 3, h 6, h 8, and h 9. The composition is administered in an amount effective to induce desensitization or immune tolerance to peanut allergens. The chemically modified peanut allergen proteins may be formulated in various dosage forms suitable for oral, subcutaneous, intramuscular or epicutaneous administration. The invention also encompasses compositions wherein the modified peanut allergen proteins are combined with excipients that enhance stability, delivery, or immunomodulatory properties.

Abstract: Provided are methods of modifying the solubility properties of individual peptides and sets of peptides of which an example embodiment includes sets of overlapping peptides prepared to be suitable for use as vaccines to modulate the immune responses of recipients. The peptides are modified to have the requisite solubility properties for tissue delivery by precipitation without extraneous binding and modification of antigenicity. According to example embodiments. the modified peptides are suitable to be used in TDBP/VDBP methods. Also provided herein are the solubility-modified peptides themselves and kits that include them. Further provided are methods of administering solubility-modified peptides with the requisite solubility properties for tissue delivery by precipitation.

Abstract: A computer system comprising a processor and a memory storing instructions that, when executed by the processor, cause the computer system to perform a set of operations. The set of operations comprises collecting domain attribute data comprising one or more domain attribute features for a domain, collecting sampled domain profile data comprising one or more domain profile features for the domain and generating, using the domain attribute data and the sampled domain profile data, a domain reputation assignment utilizing a neural network.

Abstract: A computer system comprising a processor and a memory storing instructions that, when executed by the processor, cause the computer system to perform a set of operations. The set of operations comprises collecting domain attribute data comprising one or more domain attribute features for a domain, collecting sampled domain profile data comprising one or more domain profile features for the domain and generating, using the domain attribute data and the sampled domain profile data, a domain reputation assignment utilizing a neural network.

Abstract: A computer system comprising a processor and a memory storing instructions that, when executed by the processor, cause the computer system to perform a set of operations. The set of operations comprises collecting domain attribute data comprising one or more domain attribute features for a domain, collecting sampled domain profile data comprising one or more domain profile features for the domain and generating, using the domain attribute data and the sampled domain profile data, a domain reputation assignment utilizing a neural network.

Abstract: The invention comprises novel inhibitors of dipeptidyl peptidase IV (DPP-IV) with beta blocker activity, pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP-IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP-IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, hypertension, and glaucoma of such other enumerated conditions as can be treated with inhibitors of DPP-IV and beta blockers.

Abstract: The invention comprises novel inhibitors of dipeptidyl peptidase IV (DPP-IV) with beta blocker activity, pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP-IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP-IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, hypertension, and glaucoma of such other enumerated conditions as can be treated with inhibitors of DPP-IV and beta blockers.