Abstract: Provided are methods of modifying the solubility properties of individual peptides and sets of peptides of which an example embodiment includes sets of overlapping peptides prepared to be suitable for use as vaccines to modulate the immune responses of recipients. The peptides are modified to have the requisite solubility properties for tissue delivery by precipitation without extraneous binding and modification of antigenicity. According to example embodiments. the modified peptides are suitable to be used in TDBP/VDBP methods. Also provided herein are the solubility-modified peptides themselves and kits that include them. Further provided are methods of administering solubility-modified peptides with the requisite solubility properties for tissue delivery by precipitation.

Abstract: A computer system comprising a processor and a memory storing instructions that, when executed by the processor, cause the computer system to perform a set of operations. The set of operations comprises collecting domain attribute data comprising one or more domain attribute features for a domain, collecting sampled domain profile data comprising one or more domain profile features for the domain and generating, using the domain attribute data and the sampled domain profile data, a domain reputation assignment utilizing a neural network.

Abstract: A computer system comprising a processor and a memory storing instructions that, when executed by the processor, cause the computer system to perform a set of operations. The set of operations comprises collecting domain attribute data comprising one or more domain attribute features for a domain, collecting sampled domain profile data comprising one or more domain profile features for the domain and generating, using the domain attribute data and the sampled domain profile data, a domain reputation assignment utilizing a neural network.

Abstract: A computer system comprising a processor and a memory storing instructions that, when executed by the processor, cause the computer system to perform a set of operations. The set of operations comprises collecting domain attribute data comprising one or more domain attribute features for a domain, collecting sampled domain profile data comprising one or more domain profile features for the domain and generating, using the domain attribute data and the sampled domain profile data, a domain reputation assignment utilizing a neural network.

Abstract: The invention comprises novel inhibitors of dipeptidyl peptidase IV (DPP-IV) with beta blocker activity, pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP-IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP-IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, hypertension, and glaucoma of such other enumerated conditions as can be treated with inhibitors of DPP-IV and beta blockers.

Abstract: The invention comprises novel inhibitors of dipeptidyl peptidase IV (DPP-IV) with beta blocker activity, pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP-IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP-IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, hypertension, and glaucoma of such other enumerated conditions as can be treated with inhibitors of DPP-IV and beta blockers.