Patents by Inventor Cathy A. Swindlehurst

Cathy A. Swindlehurst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11713293
    Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: August 1, 2023
    Assignee: NovoMedix, LLC
    Inventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
  • Publication number: 20230201144
    Abstract: Provided herein are a biarylsulfonamide, e.g., a compound of Formula (IA), and a pharmaceutical composition thereof. Also provided herein is a method of treating a fibrotic lung disease with a biarylsulfonamide, alone or in combination with an antifibrotic agent. Additionally, provided herein is a method of slowing the rate of decline in pulmonary function in a subject having a fibrotic lung disease with a biarylsulfonamide, alone or in combination with an antifibrotic agent.
    Type: Application
    Filed: May 31, 2021
    Publication date: June 29, 2023
    Applicant: NovoMedix, LLC
    Inventors: Cathy A. Swindlehurst, Kyle W.H. Chan, Laura Graciana Corral, Paul E. Erdman, Leah M. Fung, Imelda Lam, Robert W. Sullivan, Eduardo Torres
  • Publication number: 20220002240
    Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation.
    Type: Application
    Filed: June 21, 2021
    Publication date: January 6, 2022
    Inventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
  • Patent number: 10988442
    Abstract: Provided herein are nitrite salts of 1,1-dimethylbiguanide; and isotopic variants thereof; and pharmaceutically acceptable hydrates and solvates thereof. Also provided herein are their pharmaceutical compositions and methods of use for treating, preventing, or ameliorating one or more symptoms of diseases associated with and/or caused by an abnormal blood glucose level. Further provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a cardiovascular disease.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: April 27, 2021
    Assignee: NovoMedix, LLC
    Inventors: Leah M. Fung, Kyle W. H. Chan, Robert W. Sullivan, Cathy A. Swindlehurst
  • Publication number: 20200062700
    Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Application
    Filed: November 5, 2019
    Publication date: February 27, 2020
    Inventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
  • Publication number: 20180327353
    Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Application
    Filed: July 26, 2018
    Publication date: November 15, 2018
    Inventors: Leah M. Fung, Kyle W.H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
  • Patent number: 10040757
    Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: August 7, 2018
    Assignee: NovoMedix, LLC
    Inventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
  • Publication number: 20180127359
    Abstract: Provided herein are nitrite salts of 1,1-dimethylbiguanide; and isotopic variants thereof; and pharmaceutically acceptable hydrates and solvates thereof. Also provided herein are their pharmaceutical compositions and methods of use for treating, preventing, or ameliorating one or more symptoms of diseases associated with and/or caused by an abnormal blood glucose level. Further provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a cardiovascular disease.
    Type: Application
    Filed: November 8, 2017
    Publication date: May 10, 2018
    Inventors: Leah M. Fung, Kyle W.H. Chan, Robert W. Sullivan, Cathy A. Swindlehurst
  • Publication number: 20170158627
    Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Application
    Filed: February 16, 2017
    Publication date: June 8, 2017
    Inventors: Leah M. Fung, Kyle W.H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
  • Patent number: 9663483
    Abstract: Provided herein are substituted furanyl compounds of formula (I), pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: May 30, 2017
    Assignee: NovoMedix, LLC
    Inventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst
  • Patent number: 9604924
    Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: March 28, 2017
    Assignee: NovoMedix, LLC
    Inventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
  • Publication number: 20160024040
    Abstract: Provided herein are substituted furanyl compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Application
    Filed: September 30, 2015
    Publication date: January 28, 2016
    Inventors: Leah M. Fung, Kyle W.H. Chan, Cathy A. Swindlehurst
  • Publication number: 20160016899
    Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Application
    Filed: September 30, 2015
    Publication date: January 21, 2016
    Inventors: Leah M. Fung, Kyle W.H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
  • Patent number: 9156781
    Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: October 13, 2015
    Assignee: NOVOMEDIX, LLC
    Inventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
  • Patent number: 9149527
    Abstract: Provided herein are substituted furanyl compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: October 6, 2015
    Assignee: NovoMedix, LLC
    Inventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst
  • Publication number: 20140309297
    Abstract: Provided herein are substituted furanyl compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Application
    Filed: April 10, 2014
    Publication date: October 16, 2014
    Applicant: NovoMedix, LLC
    Inventors: Leah M. FUNG, Kyle W.H. CHAN, Cathy A. SWINDLEHURST
  • Publication number: 20140155477
    Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Application
    Filed: November 27, 2013
    Publication date: June 5, 2014
    Applicant: NOVOMEDIX, LLC
    Inventors: Leah M. Fung, Kyle W.H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
  • Patent number: 8722731
    Abstract: Provided herein are substituted furanyl compounds of formula (I), pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: May 13, 2014
    Assignee: NovoMedix, LLC
    Inventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst
  • Publication number: 20130116317
    Abstract: Provided herein are substituted furanyl compounds of formula (I), pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
    Type: Application
    Filed: June 7, 2011
    Publication date: May 9, 2013
    Applicant: NOVOMEDIX, LLC
    Inventors: Leah M. Fung, Kyle W.H. Chan, Cathy A. Swindlehurst