Patents by Inventor Cathy A. Swindlehurst
Cathy A. Swindlehurst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11713293Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: GrantFiled: June 21, 2021Date of Patent: August 1, 2023Assignee: NovoMedix, LLCInventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
-
Publication number: 20230201144Abstract: Provided herein are a biarylsulfonamide, e.g., a compound of Formula (IA), and a pharmaceutical composition thereof. Also provided herein is a method of treating a fibrotic lung disease with a biarylsulfonamide, alone or in combination with an antifibrotic agent. Additionally, provided herein is a method of slowing the rate of decline in pulmonary function in a subject having a fibrotic lung disease with a biarylsulfonamide, alone or in combination with an antifibrotic agent.Type: ApplicationFiled: May 31, 2021Publication date: June 29, 2023Applicant: NovoMedix, LLCInventors: Cathy A. Swindlehurst, Kyle W.H. Chan, Laura Graciana Corral, Paul E. Erdman, Leah M. Fung, Imelda Lam, Robert W. Sullivan, Eduardo Torres
-
Publication number: 20220002240Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation.Type: ApplicationFiled: June 21, 2021Publication date: January 6, 2022Inventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
-
Patent number: 10988442Abstract: Provided herein are nitrite salts of 1,1-dimethylbiguanide; and isotopic variants thereof; and pharmaceutically acceptable hydrates and solvates thereof. Also provided herein are their pharmaceutical compositions and methods of use for treating, preventing, or ameliorating one or more symptoms of diseases associated with and/or caused by an abnormal blood glucose level. Further provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a cardiovascular disease.Type: GrantFiled: November 8, 2017Date of Patent: April 27, 2021Assignee: NovoMedix, LLCInventors: Leah M. Fung, Kyle W. H. Chan, Robert W. Sullivan, Cathy A. Swindlehurst
-
Publication number: 20200062700Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: ApplicationFiled: November 5, 2019Publication date: February 27, 2020Inventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
-
Publication number: 20180327353Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: ApplicationFiled: July 26, 2018Publication date: November 15, 2018Inventors: Leah M. Fung, Kyle W.H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
-
Patent number: 10040757Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: GrantFiled: February 16, 2017Date of Patent: August 7, 2018Assignee: NovoMedix, LLCInventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
-
Publication number: 20180127359Abstract: Provided herein are nitrite salts of 1,1-dimethylbiguanide; and isotopic variants thereof; and pharmaceutically acceptable hydrates and solvates thereof. Also provided herein are their pharmaceutical compositions and methods of use for treating, preventing, or ameliorating one or more symptoms of diseases associated with and/or caused by an abnormal blood glucose level. Further provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a cardiovascular disease.Type: ApplicationFiled: November 8, 2017Publication date: May 10, 2018Inventors: Leah M. Fung, Kyle W.H. Chan, Robert W. Sullivan, Cathy A. Swindlehurst
-
Publication number: 20170158627Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: ApplicationFiled: February 16, 2017Publication date: June 8, 2017Inventors: Leah M. Fung, Kyle W.H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
-
Patent number: 9663483Abstract: Provided herein are substituted furanyl compounds of formula (I), pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: GrantFiled: September 30, 2015Date of Patent: May 30, 2017Assignee: NovoMedix, LLCInventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst
-
Patent number: 9604924Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: GrantFiled: September 30, 2015Date of Patent: March 28, 2017Assignee: NovoMedix, LLCInventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
-
Publication number: 20160024040Abstract: Provided herein are substituted furanyl compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: ApplicationFiled: September 30, 2015Publication date: January 28, 2016Inventors: Leah M. Fung, Kyle W.H. Chan, Cathy A. Swindlehurst
-
Publication number: 20160016899Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: ApplicationFiled: September 30, 2015Publication date: January 21, 2016Inventors: Leah M. Fung, Kyle W.H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
-
Patent number: 9156781Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: GrantFiled: November 27, 2013Date of Patent: October 13, 2015Assignee: NOVOMEDIX, LLCInventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
-
Patent number: 9149527Abstract: Provided herein are substituted furanyl compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: GrantFiled: April 10, 2014Date of Patent: October 6, 2015Assignee: NovoMedix, LLCInventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst
-
Publication number: 20140309297Abstract: Provided herein are substituted furanyl compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: ApplicationFiled: April 10, 2014Publication date: October 16, 2014Applicant: NovoMedix, LLCInventors: Leah M. FUNG, Kyle W.H. CHAN, Cathy A. SWINDLEHURST
-
Publication number: 20140155477Abstract: Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: ApplicationFiled: November 27, 2013Publication date: June 5, 2014Applicant: NOVOMEDIX, LLCInventors: Leah M. Fung, Kyle W.H. Chan, Cathy A. Swindlehurst, Robert W. Sullivan
-
Patent number: 8722731Abstract: Provided herein are substituted furanyl compounds of formula (I), pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: GrantFiled: June 7, 2011Date of Patent: May 13, 2014Assignee: NovoMedix, LLCInventors: Leah M. Fung, Kyle W. H. Chan, Cathy A. Swindlehurst
-
Publication number: 20130116317Abstract: Provided herein are substituted furanyl compounds of formula (I), pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.Type: ApplicationFiled: June 7, 2011Publication date: May 9, 2013Applicant: NOVOMEDIX, LLCInventors: Leah M. Fung, Kyle W.H. Chan, Cathy A. Swindlehurst