Patent number: 12385102
Abstract: Assays and methods for detecting resistance to beta-lactam antibiotics including detection of multiple ?-lactamase family specific gene targets by polymerase chain reaction or microarray. One or more kits including primers and/or probes for identification of ?-lactamase genes selected from the group consisting of one or more of the following: MOX-like, FOX-like, ACC-like, ACT/MIR-like, CMY-2-like, DHA-like, CTX-M-14-like, CTX-M-15-like, VIM-like, NDM-like, IMP-like, KPC-like, and OXA-48-like, OXA-51-like, OXA-143-like, OXA-58-like, OXA-23-like, OXA-24/40-like, TEM-like, and SHV-like. A kit may also include one or more primers and/or probes for the identification a non-beta lactamase gene family which confers antibiotic resistance, such as the MCR-1 gene.
Type:
Grant
Filed:
June 9, 2023
Date of Patent:
August 12, 2025
Assignees:
STRECK, LLC, CREIGHTON UNIVERSITY
Inventors:
Maria Torres-Gonzalez, Nancy Hanson, Joel Lechner, Stephanie Cossette, Cathy Scheer, Matthew R. Kreifels, Stacey Morrow, Christopher Connelly, Laura R. Porter, Randy Fowler