Abstract: The invention relates to a method for guaranteeing the reliability of real-time scrambling and message transmission by a train control center system. The method comprises the following steps: S1, starting the system for offline message loading and reading; S2, obtaining message data to be scrambled; S3, sending the message to be scrambled to a scrambling operation board for scrambling; S4, performing inverse decoding processing on an operation board; S5, performing comparison after decoding; and S6, outputting effective message data. Compared with the prior art, the invention has the advantages of being capable of guaranteeing the safety and reliability of message data.