Patents by Inventor Cecelia Pearson

Cecelia Pearson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peroxisome proliferation activated receptor alpha (PPAR?) signatures
    Patent number: 7778782
    Abstract: The present invention includes methods and apparatus for use in rapid testing for and prediction of a PPAR? response (i.e. a response similar to that of PPAR? agonists). The invention includes a PPAR? response signature comprising a set of twenty genes. The invention discloses methods whereby the differential expression of the genes of the PPAR? response signature may be used to predict whether a compound will induce a PPAR? response in a test subject.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: August 17, 2010
    Assignee: Entelos, Inc.
    Inventors: Cecelia Pearson, Michael Furness, Stuart Tugendreich, Georges Natsoulis
  • Biomarkers For Assessing Altherosclerotic Potential
    Publication number: 20100120050
    Abstract: The invention also provides methods, apparatuses and reagents useful for predicting future atherosclerosis based on expression levels of genes selected from the set of 68 genes with differential expression in response to pioglitazone and rosiglitazone. The invention also discloses reagent sets and biomarkers for predicting progression of atherosclerosis induced by anti-diabetic therapy in a subject. In one particular embodiment the invention provides a method for predict whether a compound will induce atherosclerosis using gene expression data from sub-acute treatments.
    Type: Application
    Filed: November 11, 2009
    Publication date: May 13, 2010
    Applicant: ENTELOS, INC.
    Inventors: Kapil Gadkar, Ananth Kadambi, Cecelia Pearson, Lynn Powell, Scott Siler, Jeff Trimmer
  • Cholesterol reduction signature
    Patent number: 7422854
    Abstract: The present invention provides methods and compositions for use in rapid test or prediction of the propensity of a test compound to induce cholesterol reduction in a subject. The invention also includes a cholesterol reduction signature as well as the method of deriving such signature.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: September 9, 2008
    Assignee: Entelos, Inc.
    Inventors: Georges Natsoulis, Stuart Tugendreich, Cecelia Pearson, Michael Furness
  • Cholestasis signature
    Patent number: 7396645
    Abstract: The present invention provides methods and compositions for use in rapid test or prediction of the propensity of a test compound to induce cholestasis in a subject. The invention also includes a Cholestasis signature database as well as the method of deriving such database.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: July 8, 2008
    Assignee: Entelos, Inc.
    Inventors: Georges Natsoulis, Cecelia Pearson, Stuart Tugendreich, Michael Furness
  • Reticulocyte depletion signatures
    Publication number: 20040259764
    Abstract: Disclosed is a method for predicting the propensity of a compound to cause depletion of reticulocytes in a mammal.
    Type: Application
    Filed: October 22, 2003
    Publication date: December 23, 2004
    Inventors: Stuart Tugendreich, Cecelia Pearson, Michael Furness, Georges Natsoulis