Patents by Inventor Cecil R. Smith, Jr.

Cecil R. Smith, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sesbanimide and the use thereof in treating leukemic tumors
    Patent number: 4532327
    Abstract: A novel alkaloid compound named "sesbanimide" has been isolated from the tissue of a leguminous plant known as Sesbania drummondii. Sesbanimide is characterized by the structural formula ##STR1## and is effective as an antineoplastic agent in animals.
    Type: Grant
    Filed: December 28, 1983
    Date of Patent: July 30, 1985
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Richard G. Powell, Cecil R. Smith, Jr.
  • Chemotherapeutically active maytansinoids: treflorine, trenudine, and N-methyltrenudone
    Patent number: 4418064
    Abstract: A novel group of maytansinoid compounds has been discovered in the seed tissue of Trewia nudiflora. They are represented by the general formula ##STR1## and are uniquely characterized by a 12-membered ring joining C-3 and the amide nitrogen at C-18, and also by a distinguishing methoxy group on the C-15 carbon. These isolates have proven to be effective in causing the remission of one or more types of malignancies.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: November 29, 1983
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Richard G. Powell, Cecil R. Smith, Jr.
  • Method of controlling the European corn borer with trewiasine
    Patent number: 4315929
    Abstract: A novel maytansinoid compound discovered in the seed tissue of Trewia nudiflora has been found to be effective in controlling a common insect pest, the European corn borer. This compound is represented by the formula: ##STR1## and is characterized by a distinguishing methoxy group on the C-15 carbon.
    Type: Grant
    Filed: January 27, 1981
    Date of Patent: February 16, 1982
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Bernard Freedman, Richard G. Powell, Cecil R. Smith, Jr.
  • Chemotherapeutically active maytansinoids from Trewia nudiflora
    Patent number: 4313946
    Abstract: A novel group of maytansinoid compounds has been discovered in the seed tissue of Trewia nudiflora. They are represented by the general formula ##STR1## and are all characterized by a distinguishing methoxy group on the C-15 carbon. These isolates have proven to be effective in causing the remission of one or more types of malignancies.
    Type: Grant
    Filed: January 27, 1981
    Date of Patent: February 2, 1982
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Richard G. Powell, Cecil R. Smith, Jr.
  • Cephalomannine and its use in treating leukemic tumors
    Patent number: 4206221
    Abstract: A novel alkaloid named "cephalomannine" has been produced from the tissue of plants belonging to the group commonly known as taxads and has proven to be effective in causing the remission of leukemic tumors in mice treated therewith.
    Type: Grant
    Filed: January 3, 1979
    Date of Patent: June 3, 1980
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Roger W. Miller, Richard G. Powell, Cecil R. Smith, Jr.
  • Synthetic cephalotaxine esters having antileukemic P388 activity
    Patent number: 4203996
    Abstract: Six acyl esters of cephalotaxine have been synthesized by ordinary and standard procedures, and all have demonstrated chemotherapeutic activity against leukemia of the strain P388 in animals.
    Type: Grant
    Filed: January 3, 1979
    Date of Patent: May 20, 1980
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Kenneth L. Mikolajczak, Cecil R. Smith, Jr.
  • Synthetic cephalotaxine esters having antileukemic activity
    Patent number: 4152333
    Abstract: Six acyl esters of cephalotaxine have been synthesized by ordinary and standard procedures, and all have demonstrated chemotherapeutic activity against leukemia in animals.
    Type: Grant
    Filed: February 22, 1978
    Date of Patent: May 1, 1979
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Kenneth L. Mikolajczak, Cecil R. Smith, Jr.
  • Synthesis of antitumor alkaloid deoxyharringtonine and its precursor 3'-0-(5-methyl-2-oxohexanoyl)-cephalotaxine
    Patent number: 3959312
    Abstract: The alkaloid deoxyharringtonine and its precursor 3'-O-(5-methyl-2-oxohexanoyl)-cephalotaxine were synthesized according to the following preferred series of reactions: Ethyl t-butyl oxalate + 1-lithio-3-methylbut-1-yne .fwdarw. t-butyl 5-methyl-2-oxohex-3-ynoate .fwdarw. t-butyl 5-methyl-2-oxohexanoate .sup.-trifluoroacetic acid 5-methyl-2-oxohexanoic acid .sup.(COCl).sbsp.2 5-methyl-2-oxohexanoyl chloride .sup.cephalotaxine 3'-O-(5-methyl-2-oxohexanoyl)-cephalotaxine .sup.lithio methyl acetate deoxyharringtonine.
    Type: Grant
    Filed: December 20, 1974
    Date of Patent: May 25, 1976
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Kenneth L. Mikolajczak, Cecil R. Smith, Jr.