Patents by Inventor Cecile Bonnet-Gonnet

Cecile Bonnet-Gonnet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150225479
    Abstract: The present invention provides stable pharmaceutical antibody formulations, including liquid formulations and lyophilized formulations, comprising an anti-IL-4/anti-IL-13 bispecific antibody, a polyaminoacid consisting of glutamic acid or aspartic acid or both randomly grafted with Vitamin E, and a cryoprotectant, wherein the formulation has a salt concentration of 50 mM or less. The present invention also provides stable pharmaceutical antibody formulations, including liquid formulations and lyophilized formulations, comprising an anti-IL-4/anti-IL-13 bispecific antibody, a polyaminoacid consisting of glutamic acid or aspartic acid or both randomly grafted with Vitamin E, a cryoprotectant, and a buffering system, wherein the pH of the formulation is about pH 7, and wherein the formulation has a salt concentration of 50 mM or less. The formulations may, optionally, further comprise a surfactant, or a stabilizing agent, or both. The present invention includes methods for making such formulations.
    Type: Application
    Filed: February 11, 2015
    Publication date: August 13, 2015
    Inventors: Sylvain Huille, Sophie Carayon, Corine Vialas, Cécile Bonnet-Gonnet, You-Ping Chan
  • Patent number: 8716217
    Abstract: The present invention relates to novel biodegradable materials based on modified polyamino acids that are useful in particular in the vectorization of active principle(s) (APs). The invention is also directed to novel pharmaceutical, cosmetic, health-food or plant-protection compositions based on these polyamino acids. The aim of the invention is to provide a novel polymeric starting material which can be used for AP vectorization and which satisfy all the requirements: biocompatibility, biodegradability, ability to easily associate with or dissolve numerous active principles and to release these active principles in vivo. This goal is achieved by the present invention, which relates to novel polyglutamates modified by cationic groups, which, if they can be deprotonated, exhibit a pKa equal to or greater than 7, and by hydrophobic groups comprising from 8 to 30 carbon atoms.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: May 6, 2014
    Inventors: You-Ping Chan, Cecile Bonnet-Gonnet, Olivier Breyne
  • Patent number: 8679540
    Abstract: The present invention relates to novel pharmaceutical formulations based on aqueous colloidal suspensions for the prolonged release of one or more active principles, and to the applications, especially therapeutic applications, of these formulations. Formulations may include an aqueous colloidal suspension of low viscosity based on micrometric particles of a water-soluble, biodegradable, amphiphilic polymer carrying hydrophobic groups and ionizable hydrophilic groups that are at least partially ionized, said particles being capable of associating spontaneously and non-covalently with an active principle, at pH=7.0, under isotonic conditions. This suspension contains multivalent ions of opposite polarity to that of the hydrophilic groups, the ratio r, defined by the formula r=n×([IM]/[GI]), where n is the valency of said multivalent ions, [IM] is the molar concentration of multivalent ions, [GI] is the molar concentration of ionizable groups GI, being between 0.3 and 10.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: March 25, 2014
    Assignee: Flamel Technologies
    Inventors: Cécile Bonnet-Gonnet, David Chognot, Olivier Soula, Alain Constancis
  • Patent number: 8481019
    Abstract: The present invention relates to novel particles comprising polyelectrolyte polymers which are transporters of active principle (AP), in particular protein and peptide active principle, and to novel modified-release pharmaceutical formulations comprising said AP microparticles. These novel particles loaded with AP release the AP over a prolonged period of time of several days, or even several weeks.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: July 9, 2013
    Assignee: Flamel Technologies
    Inventors: Cecile Bonnet-Gonnet, Frédéric Checot, You-Ping Chan, Olivier Breyne
  • Patent number: 8236353
    Abstract: The present invention relates to pharmaceutical formulations for the release of an active principle (AP) over a sustained period of time. The invention relates to a liquid formulation comprising at least one active principle (AP) and an aqueous suspension based on colloidal particles of a polymer (PO), wherein said formulation satisfies the following four conditions: (a) the PO is a polyamino acid comprising glutamic residues, wherein some glutamic residues each carry a pendant cationic group (CG), said CG being identical or different from one another, and other glutamic residues each carry a pendent hydrophobic group (GH), said GH being identical or different from one another, (b) the pHf value of the pH of said formulation is between 3.0 and 6.5; (c) at the pHf value, the PO forms a colloidal solution which associates spontaneously and noncovalently with the AP; (d) 1 ml of said formulation precipitates during mixing with a volume of 1 ml of a test buffer solution Tp.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: August 7, 2012
    Assignee: Flamel Technologies
    Inventors: Frédéric Checot, Cecile Bonnet-Gonnet, You-Ping Chan, Olivier Breyne, Remi Meyrueix
  • Publication number: 20120156256
    Abstract: The present invention relates to novel nanoparticles formed by at least one active ingredient and by at least two polyelectrolytes of opposite polarity, in particular characterized in that at least one of the two polyelectrolytes bears hydrophobic side groups and at least one of the two polyelectrolytes bears side groups of the polyalkylene glycol type, said nanoparticles having an average diameter ranging from 10 to 100 nm and comprising a quantity of groups of the polyalkylene glycol type such that the mass ratio wPAG of polyalkylene glycol relative to the total polymer is greater than or equal to 0.05.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Applicant: Flamel Technologies
    Inventors: Cecile Bonnet-Gonnet, Rémi Meyrueix
  • Publication number: 20090012028
    Abstract: The present invention relates to novel biodegradable materials based on modified polyamino acids that are useful in particular in the vectorization of active principle(s) (APs). The invention is also directed to novel pharmaceutical, cosmetic, health-food or plant-protection compositions based on these polyamino acids. The aim of the invention is to provide a novel polymeric starting material which can be used for AP vectorization and which satisfy all the requirements: biocompatibility, biodegradability, ability to easily associate with or dissolve numerous active principles and to release these active principles in vivo. This goal is achieved by the present invention, which relates to novel polyglutamates modified by cationic groups, which, if they can be deprotonated, exhibit a pKa equal to or greater than 7, and by hydrophobic groups comprising from 8 to 30 carbon atoms.
    Type: Application
    Filed: May 5, 2008
    Publication date: January 8, 2009
    Applicant: Flamel Technologies, S.A.
    Inventors: You-Ping Chan, Cecile Bonnet-Gonnet, Olivier Breyne
  • Publication number: 20090011028
    Abstract: The present invention relates to novel pharmaceutical formulations for the release of an active principle (AP) over a sustained period of time of several days, or even several weeks. The invention relates, in a first aspect, to a liquid formulation comprising at least one active principle (AP) and an aqueous suspension based on colloïdal particles of a polymer (PO), wherein said formulation satisfies the following four conditions: (a) the polymer (PO) is a polyamino acid comprising glutamic residues, wherein some glutamic residues each carry a pendant cationic group (CG), said cationic groups being identical or different from one another, and other glutamic residues each carry a pendent hydrophobic group (GH), said hydrophobic groups (GH) being identical or different from one another, (b) the pHf value of the pH of said formulation is between 3.0 and 6.
    Type: Application
    Filed: May 5, 2008
    Publication date: January 8, 2009
    Applicant: Flamel Technologies, S.A.
    Inventors: Frederic Checot, Cecile Bonnet-Gonnet, You-Ping Chan, Olivier Breyne, Remi Meyrueix
  • Publication number: 20090011039
    Abstract: The present invention relates to novel particles comprising polyelectrolyte polymers which are transporters of active principle (AP), in particular protein and peptide active principle, and to novel modified-release pharmaceutical formulations comprising said AP microparticles. These novel particles loaded with AP release the AP over a prolonged period of time of several days, or even several weeks.
    Type: Application
    Filed: May 5, 2008
    Publication date: January 8, 2009
    Applicant: Flamel Technologies, S.A.
    Inventors: Cecile Bonnet-Gonnet, Frederic Checot, You-Ping Chan, Olivier Breyne
  • Patent number: 7439292
    Abstract: The invention relates to the use of a block copolymer having at least one block that comprises phosphate and/or phosphonate functions, as an additive for film-forming compositions, such as paint, latex or mastic which is optionally siliconised in order to ensure or promote the adhesion of the aforementioned compositions on a metallic surface or to protect said metallic surface against corrosion. The invention also relates to film-forming compositions comprising the abovementioned block copolymers.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: October 21, 2008
    Assignee: Rhodia Chimie
    Inventors: Mathias Destarac, Cécile Bonnet-Gonnet, Arnaud Cadix
  • Publication number: 20080026070
    Abstract: The present invention relates to novel pharmaceutical formulations based on aqueous colloidal suspensions for the prolonged release of one or more active principles—AP—particularly protein and peptide active principles, and to the applications, especially therapeutic applications, of these formulations. This formulation comprises an aqueous colloidal suspension of low viscosity based on micrometric particles of a water-soluble, biodegradable, amphiphilic polymer PO carrying hydrophobic groups (GH)— alpha-tocopherol—and ionizable hydrophilic groups (GI)—Glu—that are at least partially ionized, said particles being capable of associating spontaneously and non-covalently with an AP, at pH=7.0, under isotonic conditions, and having a size of between 0.5 and 100 ?m.
    Type: Application
    Filed: June 11, 2007
    Publication date: January 31, 2008
    Applicant: Flamel Technologies, Inc.
    Inventor: Cecile Bonnet-Gonnet
  • Patent number: 7169309
    Abstract: The invention relates to a particular polymer which is derived from a copolymer polysaccharide formed by a main chain comprising similar or different anhydrohexose units and branches including at least one neutral or anionic anhydropentose and/or anhydrohexose unit. Moreover, the invention relates to the use of said polymer in the treatment of aqueous media, in particular the treatment of aqueous effluents containing heavy metals, the treatment of waste water, drinking water and for sludge conditioning. Said derivative polymer comprises one or more units bearing an oxime function at least at position C2.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: January 30, 2007
    Assignee: Rhodia Chimie
    Inventors: Etienne Fleury, Cécile Bonnet-Gonnet, Yvette Pescher
  • Publication number: 20050181225
    Abstract: The invention relates to the use of a block copolymer having at least one block that comprises phosphate and/or phosphonate functions in order to produce a deposit on a metallic surface, such as a steel or aluminium surface, which can be used, for example, to improve the effectiveness of the subsequent application of a film-forming composition on the thus altered surface or to protect the metallic surface against corrosion. The invention also relates to a method of applying paint or mastic compositions to a metallic surface, which involves the above-mentioned inventive use of said block copolymers, and the coated metallic materials that can be produced using said application method.
    Type: Application
    Filed: March 12, 2003
    Publication date: August 18, 2005
    Inventors: Mathias Destarac, Cecile Bonnet-Gonnet, Arnaud Cadix
  • Publication number: 20050119386
    Abstract: The invention relates to the use of a block copolymer having at least one block that comprises phosphate and/or phosphonate functions, as an additive for film-forming compositions, such as paint, latex or mastic which is optionally siliconised in order to ensure or promote the adhesion of the aforementioned compositions on a metallic surface or to protect said metallic surface against corrosion. The invention also relates to film-forming compositions comprising the abovementioned block copolymers.
    Type: Application
    Filed: March 13, 2003
    Publication date: June 2, 2005
    Inventors: Mathias Destarac, Cecile Bonnet-Gonnet, Arnaud Cadix
  • Publication number: 20040217064
    Abstract: The invention relates to a particular polymer which is derived from a copolymer polysaccharide formed by a main chain comprising similar or different anhydrohexose units and branches including at least one neutral or anionic anhydropentose and/or anhydrohexose unit. Moreover, the invention relates to the use of said polymer in the treatment of aqueous media, in particular the treatment of aqueous effluents containing heavy metals, the treatment of waste water, drinking water and for sludge conditioning. Said derivative polymer comprises one or more units bearing an oxime function at least at position C2.
    Type: Application
    Filed: June 18, 2004
    Publication date: November 4, 2004
    Inventors: Etienne Fleury, Cecile Bonnet-Gonnet, Yvette Pescher
  • Patent number: 6727204
    Abstract: The invention concerns the use, in an aqueous spray mixture comprising a phytosanitary formulation, of an anti-leaching agent comprising: at least a polyhydroxyl and/or polycarboxyl polymer or copolymer; at least a crosslinking agent comprising a metal selected among columns IVA, IB and IIIB of the periodic table; said anti-leaching agent being, in the aqueous spray mixture, in the form of an aqueous solution or dispersion having a polymer or copolymer concentration such that the viscosity of the anti-leaching agent is not more than 10 times the viscosity of the aqueous solution in polymer or copolymer without crosslinking agent, having the same concentration.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: April 27, 2004
    Assignee: Rhodia Chimie
    Inventors: Vance Bergeron, Cécile Bonnet-Gonnet, Jean-Christophe Castaing, Giles Guerin
  • Publication number: 20040071871
    Abstract: The invention concerns the use of amphiphilic block copolymer, comprising at least a hydrophilic block and at least a hydrophobic block, as additive for film-forming aqueous compositions such as, in particular, paint, latex or sealant optionally containing silicone to provide or promote adhesion to said compositions on a low-energy surface such as a plastic or thermoplastic polymer surface. The invention also concerns the film-forming aqueous compositions comprising said amphiphilic block copolymers.
    Type: Application
    Filed: August 25, 2003
    Publication date: April 15, 2004
    Inventors: Lionel Queval, Cecile Bonnet-Gonnet, Mathias Destarac
  • Publication number: 20040044130
    Abstract: The invention concerns a heat thickening composition for coating baths comprising at least a heat-sensitive copolymer, characterised in that said copolymer has a comb structure and consists of a polymeric segment called skeleton segment whereto are grafted at least two polymeric lateral segments, identical or different, with either the skeleton segments and/or the lateral segments having a low critical solubility temperature (LCST) ranging between 30 and 80° C. The invention also concerns a coating bath comprising said composition and their uses for coating paper or cardboard.
    Type: Application
    Filed: August 18, 2003
    Publication date: March 4, 2004
    Inventors: Marie-Pierre Labeau, Jean-Christophe Castaing, Francis Dobler, Cecile Bonnet-Gonnet, Dominique Charmot
  • Patent number: 6437040
    Abstract: The invention relates to water-soluble block copolymers comprising at least one block of hydrophobic nature and at least one block of hydrophilic nature, the block of hydrophobic nature exhibiting hydrophilic units in an amount of between 33% and 99% by weight with respect to the total weight of the units of the hydrophobic block. These copolymers are preferably diblocks or triblocks and are prepared by a polymerization process referred to as a living or controlled. Control of their hydrophilic-lipophilic balance makes it possible to adjust their solubility in water and their self-association properties. These copolymers can be used in particular as adhesion agents or wetting agents.
    Type: Grant
    Filed: February 26, 2001
    Date of Patent: August 20, 2002
    Assignee: Rhodia Chimie
    Inventors: Olivier Anthony, Cécile Bonnet-Gonnet, Mathias Destarac, Roya Farhoosh, Mathieu Joanicot, Gilda Lizarraga, Roland Reeb, Jean-Marie Schwob
  • Patent number: RE46686
    Abstract: The present invention relates to novel pharmaceutical formulations based on aqueous colloidal suspensions for the prolonged release of one or more active principles, and to the applications, especially therapeutic applications, of these formulations. Formulations may include an aqueous colloidal suspension of low viscosity based on micrometric particles of a water-soluble, biodegradable, amphiphilic polymer carrying hydrophobic groups and ionizable hydrophilic groups that are at least partially ionized, said particles being capable of associating spontaneously and non-covalently with an active principle, at pH=7.0, under isotonic conditions. This suspension contains multivalent ions of opposite polarity to that of the hydrophilic groups, the ratio r, defined by the formula r=n×([IM]/[GI]), where n is the valency of said multivalent ions, [IM] is the molar concentration of multivalent ions, [GI] is the molar concentration of ionizable groups GI, being between 0.3 and 10.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: January 30, 2018
    Assignee: FLAMEL IRELAND LIMITED
    Inventors: Cécile Bonnet-Gonnet, David Chognot, Olivier Soula, Alain Constancis