Patents by Inventor Cecile Casterman
Cecile Casterman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110257372Abstract: There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.Type: ApplicationFiled: April 1, 2011Publication date: October 20, 2011Applicant: Vrije Universiteit BrusselInventors: Cecile Casterman, Raymond Hamers
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Patent number: 7790367Abstract: There are provided methods for screening a library of VHH polypeptides for VHH polypeptides that bind to an antigen including subjecting a library of VHH polypeptides to antigen-affinity selection with the antigen.Type: GrantFiled: September 14, 2006Date of Patent: September 7, 2010Assignee: Vrije Universiteit BrusselInventors: Cecile Casterman, Raymond Hamers
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Patent number: 7786047Abstract: The invention relates to an immunoglobulin having determined antigen specificity, and having a variable fragment which is derived from a so-called heavy-chain immunoglobulin having two heavy polypeptide chains capable of recognizing and binding one or several antigens and which is further naturally devoid of light chains, wherein the immunoglobulin having determined antigen specificity is devoid of CH1 constant region between the variable region and the hinge region and has within its constant region at least part of a constant region of a human antibody.Type: GrantFiled: February 10, 2006Date of Patent: August 31, 2010Assignee: Vrije Universiteit BrusselInventors: Cecile Casterman, Raymond Hamers
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Patent number: 7722871Abstract: The invention relates to an immunoglobulin having determined antigen specificity, and having a variable fragment which is obtainable from a camelid heavy-chain immunoglobulin having two heavy polypeptide chains capable of recognizing and binding an antigen and which is further devoid of polypeptide light chains, wherein the immunoglobulin having determined antigen specificity is devoid of a CH1 constant region between the variable region and the hinge region and has within its constant region at least part of a constant region of a human antibody.Type: GrantFiled: February 10, 2006Date of Patent: May 25, 2010Assignee: Vrije Universiteit BrusselInventors: Cecile Casterman, Raymond Hamers
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Publication number: 20070238133Abstract: There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.Type: ApplicationFiled: April 20, 2007Publication date: October 11, 2007Applicant: Vrije Universiteit BrusselInventors: Cecile Casterman, Raymond Hamers
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Publication number: 20070077240Abstract: The invention relates to an immunoglobulin having determined antigen specificity, and having a variable fragment which is derived from a so-called heavy-chain immunoglobulin having two heavy polypeptide chains capable of recognizing and binding one or several antigens and which is further naturally devoid of light chains, wherein the immunoglobulin having determined antigen specificity is devoid of CH1 constant region between the variable region and the hinge region and has within its constant region at least part of a constant region of a human antibody.Type: ApplicationFiled: February 10, 2006Publication date: April 5, 2007Inventors: Cecile Casterman, Raymond Hamers
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Publication number: 20070025985Abstract: There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.Type: ApplicationFiled: September 14, 2006Publication date: February 1, 2007Applicant: Vrije Universiteit BrusselInventors: Cecile Casterman, Raymond Hamers
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Publication number: 20060134107Abstract: The invention relates to an immunoglobulin having determined antigen specificity, and having a variable fragment which is derived from a so-called heavy-chain immunoglobulin having two heavy polypeptide chains capable of recognizing and binding one or several antigens and which is further naturally devoid of light chains, wherein the immunoglobulin having determined antigen specificity is devoid of CH1 constant region between the variable region and the hinge region and has within its constant region at least part of a constant region of a human antibody.Type: ApplicationFiled: February 10, 2006Publication date: June 22, 2006Inventors: Cecile Casterman, Raymond Hamers
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Publication number: 20060121026Abstract: The invention relates to an immunoglobulin having determined antigen specificity, and having a variable fragment which is derived from a so-called heavy-chain immunoglobulin having two heavy polypeptide chains capable of recognizing and binding one or several antigens and which is further naturally devoid of light chains, wherein the immunoglobulin having determined antigen specificity is devoid of CH1 constant region between the variable region and the hinge region and has within its constant region at least part of a constant region of a human antibody.Type: ApplicationFiled: February 10, 2006Publication date: June 8, 2006Inventors: Cecile Casterman, Raymond Hamers
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Publication number: 20040253638Abstract: There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.Type: ApplicationFiled: January 5, 2004Publication date: December 16, 2004Applicant: Vrije Universiteit BrusselInventors: Cecile Casterman, Raymond Hamers
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Patent number: 6765087Abstract: There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.Type: GrantFiled: April 19, 1999Date of Patent: July 20, 2004Assignee: Vrije Universiteit BrusselInventors: Cecile Casterman, Raymond Hamers
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Patent number: 6015695Abstract: There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.Type: GrantFiled: June 6, 1995Date of Patent: January 18, 2000Assignee: Vrije Universiteit BrusselInventors: Cecile Casterman, Raymond Hamers
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Patent number: 6005079Abstract: There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.Type: GrantFiled: June 6, 1995Date of Patent: December 21, 1999Assignee: Vrije Universiteit BrusselsInventors: Cecile Casterman, Raymond Hamers
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Patent number: 5874541Abstract: There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.Type: GrantFiled: June 6, 1995Date of Patent: February 23, 1999Assignee: Vrije UniversiteitInventors: Cecile Casterman, Raymond Hamers
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Patent number: 5840526Abstract: There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.Type: GrantFiled: June 6, 1995Date of Patent: November 24, 1998Assignee: Vrije Universiteit BrusselInventors: Cecile Casterman, Raymond Hamers
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Patent number: 5800988Abstract: There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.Type: GrantFiled: June 6, 1995Date of Patent: September 1, 1998Assignee: Vrije Universiteit BrusselInventors: Cecile Casterman, Raymond Hamers
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Patent number: 5759808Abstract: There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.Type: GrantFiled: June 6, 1995Date of Patent: June 2, 1998Assignee: Vrije Universiteit BrusselInventors: Cecile Casterman, Raymond Hamers