Patents by Inventor Cecilia S. L. Ku

Cecilia S. L. Ku has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analogs of hirudin
    Patent number: 6028170
    Abstract: A tyrosine-substituted hirudin analog has antithrombogenic activity. Further simultaneous reaction at native tyrosine residues is prevented by mutation at those sites to encode nonreactive amino acids. Several novel strategies for coupling the hirudin analog to solid surfaces while simultaneously conserving antithrombogenic activity are disclosed.
    Type: Grant
    Filed: May 18, 1998
    Date of Patent: February 22, 2000
    Assignee: Baxter International Inc.
    Inventors: Cecilia S. L. Ku, Richard Johnson, Julian Breillatt
  • Analogs of hirudin
    Patent number: 5837808
    Abstract: A tyrosine-substituted hirudin analog has antithrombogenic activity. Further simultaneous reaction at native tyrosine residues is prevented by mutation at those sites to encode nonreactive amino acids. Several novel strategies for coupling the hirudin analog to solid surfaces while simultaneously conserving antithrombogenic activity are disclosed.
    Type: Grant
    Filed: June 19, 1995
    Date of Patent: November 17, 1998
    Assignee: Baxter International Inc.
    Inventors: Cecilia S. L. Ku, Richard Johnson, Julian P. Breillatt, Jr.
  • Thromboresistant materials and methods for making same
    Patent number: 5053453
    Abstract: Thromboresistant materials are disclosed comprising hirudin or hirudin derivatives covalently linked to support materials such that the resultant composition has substantially the same biological activity as hirudin. Methods for making such compositions are also disclosed.
    Type: Grant
    Filed: January 15, 1991
    Date of Patent: October 1, 1991
    Assignee: Baxter International Inc.
    Inventor: Cecilia S. L. Ku