Patents by Inventor Cedric H. Hassall
Cedric H. Hassall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 4302398Abstract: The present invention relates to naphthacene derivatives. More particularly, the invention is concerned with a process for the manufacture of hexahydronaphthacene derivatives and with certain of said derivatives per se. The invention is also concerned with novel intermediates occurring in said process and with the preparation thereof.There are presented hexahydronaphthacene derivatives of the formula ##STR1## wherein R.sup.1 represents a lower alkyl or esterified carboxy group or a group of the formula ##STR2## , in which R.sup.2 and R.sup.3 together form an oxo group or a protected oxo group and X represents a hydrogen atom or a hydroxy or acyloxy group, or--(CH.sub.2).sub.n --OY bin which n stands for 1 or 2 and Y represents a hydrogen atom or an alkyl or acyl group.Also presented are intermediates and a process to produce the compounds of formula I.Type: GrantFiled: August 6, 1980Date of Patent: November 24, 1981Assignee: Hoffmann-La Roche Inc.Inventors: Cedric H. Hassall, Michael J. Broadhurst, Gareth J. Thomas
-
Patent number: 4250085Abstract: Peptide derivatives provided by the present invention are compounds of the general formula ##STR1## wherein R.sup.1 represents a hydrogen atom or the methyl or hydroxymethyl group or a mono-, di- or trihalomethyl mgroup; R.sup.2 represents the characterizing group of an .alpha.-amino acid of the type normally found in proteins or a lower alkyl or hydroxy- (lower alkyl) group other than the characterising group of an .alpha.-amino acid of the type normally found in proteins; R.sup.3 represents a lower alkyl, lower cycloalkyl, lower alkenyl, aryl or aryl-(lower alkyl) group; R.sup.4 represents a hydrogen atom or a lower alkyl group; n stands for 1,2 or 3; the configuration at the carbon atom designated as (a) is (R) when R.sup.1 represents other than a hydrogen atom and the configuration at the carbon atom designated as (b) is (L) when R.sup.2 represents other than a hydrogen atom, and pharmaceutically acceptable salts thereof.Type: GrantFiled: December 20, 1978Date of Patent: February 10, 1981Assignee: Hoffmann-La Roche Inc.Inventors: Frank R. Atherton, Michael J. Hall, Cedric H. Hassall, Robert W. Lambert, Peter S. Ringrose
-
Patent number: 4187216Abstract: The present disclosure relates to dipeptide derivatives. These novel compounds are useful as elastase inhibitors.Type: GrantFiled: June 8, 1977Date of Patent: February 5, 1980Assignee: Hoffmann-La Roche Inc.Inventors: Cedric H. Hassall, William H. Johnson, Noel A. Roberts
-
Patent number: 4176116Abstract: The present disclosure relates to dipeptide derivatives. The novel compounds are useful as elastase inhibitors.Type: GrantFiled: June 8, 1977Date of Patent: November 27, 1979Assignee: Hoffmann-La Roche Inc.Inventors: Cedric H. Hassall, William H. Johnson, Noel A. Roberts
-
Patent number: 4143134Abstract: The present disclosure relates to halo-phosphonopeptides. The subject compounds are antibacterial agents and also potentiate the activity of antibiotics.Type: GrantFiled: July 13, 1977Date of Patent: March 6, 1979Assignee: Hoffmann-La Roche Inc.Inventors: Frank R. Atherton, Michael J. Hall, Cedric H. Hassall, Robert W. Lambert, Peter S. Ringrose
-
Patent number: 4134972Abstract: Compositions having antibiotic properties containing as antibiotic potentiators peptides of the formula ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkyl, lower cycloalkyl, (lower cycloalkyl)-(lower alkyl), aryl or aryl(lower alkyl) group (said group being optionally substituted as the case may require by one or more amino, hydroxy, thio, methylthio, carboxy or guanidino groups so as to form the characterizing group of a naturally occurring L .alpha.-amino acid);R.sup.2 and R.sup.3 each represent the characterizing group of an .alpha.-amino acid of the type normally found in proteins with the proviso that R.sup.3 cannot represent a hydrogen atom when n is zero and R.sup.1 is a hydrogen atom or the phenyl group; R.sup.4 represents a hydroxy or methyl group; n stands for zero, 1, 2 or 3; and single asterisks denote that the configuration at the carbon atom so-marked is L when R.sup.2 or R.sup.Type: GrantFiled: November 11, 1977Date of Patent: January 16, 1979Assignee: Hoffmann-La Roche Inc.Inventors: Frank R. Atherton, Michael J. Hall, Cedric H. Hassall, Peter S. Ringrose, Robert W. Lambert
-
Patent number: 4128542Abstract: There is provided peptide derivatives of the general formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each represent the characterizing group of an .alpha.-amino acid of the type normally found in proteins; R.sup.4 represents a hydroxy or methyl group; n stands for zero, 1, 2 or 3; the configuration at the carbon atoms designated as (a), (b) and (c) is L (when R.sup.1 or R.sup.2 .noteq. H); and the configuration at the carbon atom designated as (d) is (R) (when R.sup.3 .noteq. H)and pharmaceutically acceptable salts thereof.The above compounds exhibit antibacterial activity against various microorganisms.Type: GrantFiled: July 5, 1977Date of Patent: December 5, 1978Assignee: Hoffmann-La Roche Inc.Inventors: Frank R. Atherton, Michael J. Hall, Cedric H. Hassall, Robert W. Lambert, Peter S. Ringrose
-
Patent number: 4127649Abstract: Compositions having antibiotic properties containing as antibiotic potentiators peptides of the formula ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkyl, lower cycloalkyl, (lower cycloalkyl)-(lower alkyl), aryl or aryl-(lower alkyl) group (said group being optionally substituted as the case may require by one or more amino, hydroxy, thio, methylthio, carboxy or guanidino groups so as to form the characterizing group of a naturally occurring L .alpha.-amino acid);R.sup.2 and R.sup.3 each represent the characterizing group of an .alpha.-amino acid of the type normally found in proteins with the proviso that R.sup.3 cannot represent a hydrogen atom when n is zero and R.sup.1 is a hydrogen atom or the phenyl group; R.sup.4 represents a hydroxy or methyl group; n stands for zero, 1, 2 or 3; and single asterisks denote that the configuration at the carbon atom so-marked is L when R.sup.2 or R.sup.Type: GrantFiled: May 23, 1977Date of Patent: November 28, 1978Assignee: Hoffmann-La Roche Inc.Inventors: Frank R. Atherton, Michael J. Hall, Cedric H. Hassall, Peter S. Ringrose, Robert W. Lambert
-
Patent number: 4105852Abstract: This invention is directed toward pharmacologically active compounds of the formula ##STR1## wherein A represents a nitrogen atom which may be substituted by a methyl, cyclopropylmethyl, di(C.sub.1-4 alkyl)aminoethyl, methoxymethyl or hydroxyethyl group and B represents a carbonyl group or A and B together represent a grouping of the formula ##STR2## in which R.sup.a represents a hydrogen atom or a lower alkyl or hydroxymethyl group and X represents a nitrogen atom or C--R.sup.b wherein R.sup.b represents a hydrogen atom or a lower alkyl or hydroxymethyl group; R represents a halogen atom or a nitro or trifluoromethyl group; R.sup.1 represents a hydrogen atom or a lower alkyl group; R.sup.2 represents an acyl group derived from a naturally occurring amino acid (all such groups which contain an asymmetric carbon atom having the L- or D,L-configuration) and R.sup.3 represents a phenyl, halophenyl or 2-pyridyl group and acid addition salts thereof.Type: GrantFiled: November 11, 1976Date of Patent: August 8, 1978Assignee: Hoffmann-La Roche Inc.Inventors: Cedric H. Hassall, William H. Johnson, Antonin Krohn, Carey E. Smithen, William A. Thomas
-
Patent number: RE30473Abstract: This invention is directed toward pharmacologically active compounds of the formula ##STR1## wherein A represents a nitrogen atom which may be substituted by a methyl, cyclopropylmethyl, di(C.sub.1-4 alkyl)aminoethyl, methoxymethyl or hydroxyethyl group and B represents a carbonyl group or A and B together represent a grouping of the formula ##STR2## in which R.sup.a represents a hydrogen or a lower alkyl or hydroxymethyl group and X represents a nitrogen atom or C-R.sup.b wherein R.sup.b represents a hydrogen atom or a lower alkyl or hydroxymethyl group; R represents a halogen atom or a nitro or trifluoromethyl group; R.sup.1 represents a hydrogen atom or a lower alkyl group; R.sup.2 represents an acyl group derived from a naturally occurring amino acid (all such groups which contain an asymmetric carbon atom having the L- or D,L-configuration) and R.sup.3 represents a phenyl, halophenyl or 2-pyridyl group and acid addition salts thereof.Type: GrantFiled: July 31, 1978Date of Patent: January 6, 1981Assignee: Hoffmann-La Roche Inc.Inventors: Cedric H. Hassall, William H. Johnson, Antonin Krohn, Carey E. Smithen, William A. Thomas