Abstract: The present invention relates to allergy field. Several independent groups have recently investigated the implication of PCSK9 on inflammation and sepsis but none of them have determine its impact on allergies and/or asthma which is a global health burden. Inventors have obtained preliminary data on wild-type (PCSK9+/+) or PCSK9-deficient mice (PCSK9 ?/?) and shown that, under basal condition and in the absence of a particular stimulus, PCSK9 deficiency significantly increases the percentage of regulatory T cells in the spleen, the mesenteric lymph nodes and Peyer's patches. Moreover, inventors have shown the effect of allergic challenge Non primary human bronchial epithelial cells on PCSK9 expression and secretion. Very interestingly, their first results obtained by Q-PCR showed that HDM and LPS increase PCSK9 mRNA levels. Accordingly, the present invention relates to inhibitors of PCSK9 for use in the treatment of asthma and/or allergic disease, such as food allergy.

Abstract: An in-flight entertainment system includes a plurality of static transceivers and an ISM band communication interference manager. The static transceivers are configured to transmit and receive radio frequency signals in the ISM band. The static transceivers are further configured to measure signals received within the ISM band from mobile transceivers within the aircraft and to measure signals received from proximately located ones of the static transceivers, and to generate measurement reports containing the measurements and containing identifiers of the proximately located ones of the static transceivers and the mobile transceivers. The ISM band communication interference manager is communicatively connected to the static transceivers, and performs operations that include receiving the measurement reports from the static transceivers, and controlling transmission power levels used by the static transceivers and the mobile transceivers responsive to the content of the measurement reports.

Abstract: The present invention relates to a method for modulating stem cells proliferation or differentiation comprising a step of contacting said stem cells with an effective amount of an activator or inhibitor of a proprotein convertase subtilisin kexin 9 (PCSK9). Inventors performed a global transcriptomic analyses in hiPSCs and showed that PCSK9 inhibition by shRNA and the intracellular PCSK9-R104C/V114A mutation negatively regulate the NODAL signaling pathway and its targets. This regulation was manifested in drastic reduction P-SMAD2/total SMAD2 protein level. This was accompanied by reduced proliferation rate where hiPSC-shPCSK9 and hiPSC-R104C/V114A demanded >1.3-fold more time to double compared to their control counterparts. They showed that PCSK9 was regulating this signaling pathway through direct physical interaction with DACT2, an intracellular attenuator of NODAL receptor and favoring its protein degradation. Thus, these findings allow to understand the differentiation and proliferation of cells.

Abstract: An in-flight entertainment system includes a plurality of static transceivers and an ISM band communication interference manager. The static transceivers are configured to transmit and receive radio frequency signals in the ISM band. The static transceivers are further configured to measure signals received within the ISM band from mobile transceivers within the aircraft and to measure signals received from proximately located ones of the static transceivers, and to generate measurement reports containing the measurements and containing identifiers of the proximately located ones of the static transceivers and the mobile transceivers. The ISM band communication interference manager is communicatively connected to the static transceivers, and performs operations that include receiving the measurement reports from the static transceivers, and controlling transmission power levels used by the static transceivers and the mobile transceivers responsive to the content of the measurement reports.

Abstract: An in-flight entertainment system includes a plurality of static transceivers and an ISM band communication interference manager. The static transceivers are configured to transmit and receive radio frequency signals in the ISM band. The static transceivers are further configured to measure signals received within the ISM band from mobile transceivers within the aircraft and to measure signals received from proximately located ones of the static transceivers, and to generate measurement reports containing the measurements and containing identifiers of the proximately located ones of the static transceivers and the mobile transceivers. The ISM band communication interference manager is communicatively connected to the static transceivers, and performs operations that include receiving the measurement reports from the static transceivers, and controlling transmission power levels used by the static transceivers and the mobile transceivers responsive to the content of the measurement reports.