Patents by Inventor Cedric Shackleton

Cedric Shackleton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis of Smith-Lemli-Optiz syndrome
    Patent number: 7192779
    Abstract: The invention provides a non-invasive assay for the detection of a SLOS affected individual by determining the ratio of at least one of the specific SLOS steroid analytes, dehydro-estriol (8-DHE3) and a dehydro-pregnanetriol (7-DHPT) to their normal steroid counterparts estriol (E3) and pregnanetriol (PT), respectively. 8-DHE3 and 7-DHPT represent metabolites which accumulate in the blood and urine of an individual with SLOS or an individual carrying a SLOS affected fetus. The invention provides for a reliable and reproducible method of screening women for SLOS affected fetuses early on in pregnancy.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: March 20, 2007
    Assignee: Children's Hospital & Research Center at Oakland
    Inventor: Cedric Shackleton
  • Dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT), methods of their synthesis
    Patent number: 7105637
    Abstract: The invention provides isolated dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT), and methods of their synthesis. These compounds are useful in diagnosis of Smith-Lemli-Optiz syndrome (SLOS).
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: September 12, 2006
    Assignees: William Marsh Rice University, Children's Hospital & Research Center at Oakland
    Inventors: Cedric Shackleton, Li-Wei Guo, William K. Wilson
  • Diagnosis of Smith-Lemli-Optiz syndrome
    Patent number: 6808932
    Abstract: The invention provides a non-invasive assay for the detection of a SLOS affected individual by determining the ratio of at least one of the specific SLOS steroid analytes, dehydro-estriol (8-DHE3) and a dehydro-pregnanetriol (7-DHPT) to their normal steroid counterparts estriol (E3) and pregnanetriol (PT), respectively. 8-DHE3 and 7-DHPT represent metabolites which accumulate in the blood and urine of an individual with SLOS or an individual carrying a SLOS affected fetus. The invention provides for a reliable and reproducible method of screening women for SLOS affected fetuses early on in pregnancy.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: October 26, 2004
    Assignee: Children's Hospital & Research Center at Oakland
    Inventor: Cedric Shackleton
  • Dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT), and methods of their synthesis
    Publication number: 20030220314
    Abstract: The invention provides isolated dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT), and methods of their synthesis. These compounds are useful in diagnosis of Smith-Lemli-Optiz syndrome (SLOS).
    Type: Application
    Filed: February 14, 2003
    Publication date: November 27, 2003
    Inventors: Cedric Shackleton, Li-Wei Guo, William K. Wilson