Patents by Inventor Celeste N. Alverez

Celeste N. Alverez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PLK1 POLO BOX DOMAIN INHIBITORS AND METHOD OF TREATING CANCER
    Publication number: 20230365568
    Abstract: Provided is a method of treating cancer, particularly cancers associated with an overexpression of polo-like kinase (Plk1), comprising administering a compound of formula (I) or a pharmaceutically acceptable salt thereof in which ring A, X1, X2, X3, X4, X5, R2, R3, R4, n, bond a, and bond b are described herein. Exemplary compounds of formula (I) and pharmaceutically acceptable salts thereof, especially those that selectively inhibit the polo box domain of Plk1, also are provided.
    Type: Application
    Filed: September 24, 2021
    Publication date: November 16, 2023
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Kyung S. Lee, Kenneth A. Jacobson, Celeste N. Alverez, Jung-Eun Park, Paola Oliva, Hobin Lee, Klara Pongorne Kirsch