Patents by Inventor Celia A. SCHIFFER

Celia A. SCHIFFER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiviral Compounds
    Publication number: 20230212203
    Abstract: The present application provides compounds and methods of treating viral infections, including viral infections caused by HIV or HTLV.
    Type: Application
    Filed: December 2, 2022
    Publication date: July 6, 2023
    Inventors: Celia A. Schiffer, Akbar Ali, Nese Kurt-Yilmaz, Linah N. Rusere, Gordon J. Lockbaum, Mina Henes
  • HEPATITIS C VIRUS NS3/4A PROTEASE INHIBITORS
    Publication number: 20230099018
    Abstract: The invention provides novel classes of HCV therapeutics that are orally available, safe and effective HCV NS3/4A protease inhibitors and are less susceptible to drug resistance than existing therapeutics. The invention also relates to pharmaceutical composition of these compounds and methods of preparation and use thereof.
    Type: Application
    Filed: August 19, 2022
    Publication date: March 30, 2023
    Inventors: Celia A. Schiffer, Akbar Ali, Ashley N. Matthew
  • Antiviral compounds
    Patent number: 11542288
    Abstract: The present application provides compounds and methods of treating viral infections, including viral infections caused by HIV or HTLV.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: January 3, 2023
    Assignee: University of Massachusetts
    Inventors: Celia A. Schiffer, Akbar Ali, Nese Kurt-Yilmaz, Linah N. Rusere, Gordon J. Lockbaum, Mina Henes
  • Method for probing at least one binding site of a protein
    Patent number: 11521704
    Abstract: At least one binding site of a protein is probed by calculating a set of molecular dynamic trajectories of a protein-ligand complex family. At least one script is applied to the molecular dynamic trajectories to form a set of tensors, and at least one second script is applied to the set of tensors to integrate the set of tensors with experimental binding data corresponding to the protein-ligand complex family to form a primary image of the binding site, thereby probing the binding site of the protein.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: December 6, 2022
    Inventors: Celia A. Schiffer, Florian Leidner, Troy W. Whitfield, Debra A. Ragland, Nese Kurt Yilmaz, Konstantin B. Zeldovich, Aysegul Ozen
  • Hepatitis C virus NS3/4A protease inhibitors
    Patent number: 11472778
    Abstract: The invention provides novel classes of HCV therapeutics that are orally available, safe and effective HCV NS3/4A protease inhibitors and are less susceptible to drug resistance than existing therapeutics. The invention also relates to pharmaceutical composition of these compounds and methods of preparation and use thereof.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: October 18, 2022
    Assignee: University of Massachusetts
    Inventors: Celia Schiffer, Akbar Ali, Ashley Matthew
  • HEPATITIS C VIRUS NS3/4A PROTEASE INHIBITORS
    Publication number: 20220227806
    Abstract: The invention provides novel classes of HCV therapeutics that are orally available, safe and effective HCV NS3/4A protease inhibitors and are less susceptible to drug resistance than existing therapeutics. The invention also relates to pharmaceutical composition of these compounds and methods of preparation and use thereof.
    Type: Application
    Filed: June 5, 2020
    Publication date: July 21, 2022
    Inventors: Celia A. Schiffer, Akbar Ali, Jacqueto Zephyr, Ashley N. Matthew, Nageswara R. Desaboini
  • Antiviral Compounds
    Publication number: 20210371439
    Abstract: The present application provides compounds and methods of treating viral infections, including viral infections caused by HIV or HTLV.
    Type: Application
    Filed: May 28, 2021
    Publication date: December 2, 2021
    Inventors: Celia A. Schiffer, Akbar Ali, Nese Kurt-Yilmaz, Linah N. Rusere, Gordon J. Lockbaum, Mina Henes
  • HEPATITIS C VIRUS NS3/4A PROTEASE INHIBITORS
    Publication number: 20200087265
    Abstract: The invention provides novel classes of HCV therapeutics that are orally available, safe and effective HCV NS3/4A protease inhibitors and are less susceptible to drug resistance than existing therapeutics. The invention also relates to pharmaceutical composition of these compounds and methods of preparation and use thereof.
    Type: Application
    Filed: June 19, 2018
    Publication date: March 19, 2020
    Inventors: Celia A. Schiffer, Akbar Ali, Ashley N. Matthew
  • Method for Probing at Least One Binding Site of a Protein
    Publication number: 20190065667
    Abstract: At least one binding site of a protein is probed by calculating a set of molecular dynamic trajectories of a protein-ligand complex family. At least one script is applied to the molecular dynamic trajectories to form a set of tensors, and at least one second script is applied to the set of tensors to integrate the set of tensors with experimental binding data corresponding to the protein-ligand complex family to form a primary image of the binding site, thereby probing the binding site of the protein.
    Type: Application
    Filed: July 25, 2018
    Publication date: February 28, 2019
    Inventors: Celia A. Schiffer, Florian Leidner, Troy W. Whitfield, Debra A. Ragland, Nese Kurt Yilmaz, Konstantin B. Zeldovich, Aysegul Ozen
  • HIV-1 Protease Inhibitors
    Publication number: 20110178092
    Abstract: Described are novel protease inhibitors and methods for using said protease inhibitors in the treatment of human immunodeficiency virus (HIV) infection.
    Type: Application
    Filed: December 19, 2007
    Publication date: July 21, 2011
    Inventors: Akbar Ali, Michael D. Altman, Saima G. Anjum, Hong Cao, Sripriya Chellappan, Miguel X. Fernandes, Michael K. Gilson, Visvaldas Kairys, Nancy King, Ellen Nalivaika, Moses Prabu, Tariq M. Rana, Kiran Kumar Sai, Celia A. Schiffer, Bruce Tidor
  • CRYSTAL STRUCTURES OF HIV-1 PROTEASE INHIBITORS BOUND TO HIV-1 PROTEASE
    Publication number: 20100173381
    Abstract: Described herein are methods for rational design of inhibitors of HIV-1 protease, and crystal structures of HIV-1 protease inhibitors bound to HIV-1 protease.
    Type: Application
    Filed: December 18, 2007
    Publication date: July 8, 2010
    Applicants: UNIVERSITY OF MASSACHUSETTS, TIBOTEC PHARMACEUTICALS LTD
    Inventors: Celia A. SCHIFFER, Madhavi NALAM, Inge DIERYNCK, Annick Ann PEETERS, Tim Hugo JONKERS