Patents by Inventor Celine MONNET

Celine MONNET has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FC MUTANTS WITH MODIFIED FUNCTIONAL ACTIVITY
    Publication number: 20230265155
    Abstract: Disclosed is a polypeptide including a mutated Fc region and having functional activity, mediated by the Fc region, that is modified compared with that of a parent polypeptide. The Fc region includes at least one combination of 2 mutations, the combination being selected from among one mutation selected from among a first set of mutations, and at least one mutation selected from among a second set of mutations, and provided that mutation (i) does not take place on the same amino acid as mutation (ii). Also disclosed are use of the polypeptide, compositions including the same, and methods for preparing the polypeptide.
    Type: Application
    Filed: March 31, 2023
    Publication date: August 24, 2023
    Inventors: Celine MONNET, Philippe MONDON, Alexandre FONTAYNE, Christophe DE ROMEUF
  • Fc mutants with modified functional activity
    Patent number: 11649271
    Abstract: Disclosed is to a polypeptide including a mutated Fc region and having functional activity, mediated by the Fc region, that is modified compared with that of a parent polypeptide. The Fc region includes at least one combination of 2 mutations, the combination being selected from among one mutation selected from among a first set of mutations, and at least one mutation selected from among a second set of mutations, and provided that mutation (i) does not take place on the same amino acid as mutation (ii). Also disclosed are use of the polypeptide, compositions including the same, and methods for preparing the polypeptide.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: May 16, 2023
    Assignee: LABORATOIRE FRANÇ-̧AIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES
    Inventors: Celine Monnet, Philippe Mondon, Alexandre Fontayne, Christophe De Romeuf
  • FC MUTANTS WITH MODIFIED FUNCTIONAL ACTIVITY
    Publication number: 20180030111
    Abstract: Disclosed is to a polypeptide including a mutated Fc region and having functional activity, mediated by the Fc region, that is modified compared with that of a parent polypeptide. The Fc region includes at least one combination of 2 mutations, the combination being selected from among one mutation selected from among a first set of mutations, and at least one mutation selected from among a second set of mutations, and provided that mutation (i) does not take place on the same amino acid as mutation (ii). Also disclosed are use of the polypeptide, compositions including the same, and methods for preparing the polypeptide.
    Type: Application
    Filed: May 6, 2016
    Publication date: February 1, 2018
    Inventors: Celine MONNET, Philippe MONDON, Alexandre FONTAYNE, Christophe DE ROMEUF
  • METHOD FOR PRODUCING VARIANTS HAVING AN FC WITH IMPROVED SIALYLATION
    Publication number: 20170260254
    Abstract: The present invention relates to a method for increasing the sialylation of an Fc fragment, including a mutation step of at least one amino acid selected from among the amino acids in positions 240 to 243, 258 to 267 and 290 to 305 of the Fc fragment, the numbering being that of the EU index or equivalent in Kabat. The present invention also relates to a method for producing a variant of a parent polypeptide including an Fc fragment, the variant having improved sialylation of the Fc fragment relatively to the parent polypeptide, which includes a mutation step of at least one amino acid selected from among the amino acids in positions 240 to 243, 258 to 267 and 290 to 305 of the Fc fragment, the numbering being that of the EU index or equivalent in Kabat.
    Type: Application
    Filed: July 31, 2015
    Publication date: September 14, 2017
    Inventors: Celine MONNET, Alexandre FONTAYNE