Abstract: Described herein are compositions and methods for enhanced drug loading into lipid-based carriers. The compositions and methods may comprise a drug-bound chiral graphene quantum dot comprising a graphene quantum dot functionalized with a non-aromatic chiral ligand having a single chiral center, wherein a chirality of the chiral graphene quantum dot matches a chirality of a lipid content of the lipid-based carrier. The drug-bound chiral graphene quantum dot permeates into the lipid-based carrier via matching of the chirality of the chiral graphene quantum dot to the chirality of the lipid content of the lipid-based carrier to load the drug into the lipid-based carrier. The compositions and methods achieve a drug loading efficiency of greater than 60% into lipid-based carriers.

Abstract: Described herein is a size-based asymmetric nanopore membrane (ANM) filtration technology for high-efficiency exosome isolation, concentration, and fractionation. The ANM design prevents exosome deformation, lysing, and fusion due to the strong external force and thus significant increases the yield (up to 92%) while preserving other advantages of size-based ultrafiltration. It also offers a unique feature of being able to flush the contaminating proteins from the exosomes. It offers higher throughput, yield, sample purity, concentration factor, and more precise size fractionation than current approaches.

Abstract: Described herein is a method for high-efficiency virus enrichment and purification using an asymmetric nanopore membrane (ANM) filtration technology. The ANM design prevents viral particle deformation, lysing, and fusion due to the strong external force and thus significant increases the yield while preserving other advantages of size-based ultrafiltration. It also offers a unique feature of being able to flush the contaminating proteins from the viral particles. It offers higher throughput, yield, sample purity, concentration factor, and more precise size fractionation than current approaches.

Abstract: Systems and methods for controlling molecular translocation in solid-state nanopores by edge field leakage. The system dramatically reduces (by orders of magnitude) and controls the fast electrophoretic velocity of molecules to realize sensitive and selective solid-state nanopore sensors for polynucleotides and sequencing platforms.

Abstract: Systems and methods for controlling molecular translocation in solid-state nanopores by edge field leakage. The system dramatically reduces (by orders of magnitude) and controls the fast electrophoretic velocity of molecules to realize sensitive and selective solid-state nanopore sensors for polynucleotides and sequencing platforms.